FGL-S Peptide

FGLs Peptide (NCAM Mimetic Peptide)

Welcome to buypeptidesonlineusa.com, your premier domestic source for high-purity research peptides. Our FGLs peptide is a synthetic dimeric compound designed as a mimetic of the Neural Cell Adhesion Molecule (NCAM), meticulously manufactured for advanced investigations into neuroregeneration, synaptic plasticity, learning and memory, and neuroprotection. We ensure your critical research is supported by uncompromising quality, transparency, and rapid fulfillment.

🚚 FREE SHIPPING ON ORDERS OVER $300 | 🔐 SECURE CHECKOUT & DISCREET PACKAGING

⚠️ Important Research Compliance Notice

This product is intended strictly for laboratory research use only and is not for human consumption or veterinary use. This product is not a medicine, drug, or medical device. It has not been evaluated by the FDA. This peptide is sold for investigational purposes by qualified researchers and professionals only.

🔬 What is FGLs Peptide?

FGLs is a synthetic dimeric peptide consisting of two identical 11-amino acid sequences connected by an iminodiacetyl linker at their N-terminals . It is rationally designed as a mimetic of the Neural Cell Adhesion Molecule (NCAM), a key protein on the cell surface that plays a fundamental role in neural development, synaptic plasticity, and cell-cell adhesion .

The name "FGL" is derived from the amino acid motif FG Loop within the second Fibronectin type III (F2) module of NCAM, which is responsible for binding to the Fibroblast Growth Factor Receptor (FGFR) . By mimicking this specific interaction, FGLs acts as an agonist, binding to FGFR and triggering intracellular signaling cascades that promote neuronal survival, differentiation, and plasticity . The "s" in FGLs denotes its dimeric structure, which enhances its potency and stability compared to the monomeric form.

This peptide is a powerful tool for researchers aiming to dissect the molecular mechanisms underlying NCAM-FGFR signaling and its downstream effects on the central nervous system (CNS) without the complexity of working with the full-length NCAM protein .

✅ Why Choose Buy Peptides Online USA for Your Research?

When you need to buy FGLs peptide online, quality and consistency are non-negotiable. Here is why discerning researchers choose us:

• Verified Purity: We provide access to independent third-party Certificate of Analysis (COA) documents, confirming purity via High-Performance Liquid Chromatography (HPLC) exceeding 98% and identity via Mass Spectrometry (MS) .
• Optimal Storage & Handling: Our FGLs is shipped in lyophilized form. For long-term stability, store desiccated at -20°C or below, protected from light and moisture. Avoid repeated freeze-thaw cycles .
• Domestic Shipping: As a USA-based supplier, we offer fast, reliable shipping. Orders typically arrive within 2-5 business days in discreet, temperature-controlled packaging.
• Research-Focused: We make no medical claims. Our service is built on integrity, providing accurately labeled products for legitimate scientific inquiry.
• Secure Transactions: Enjoy peace of mind with secure checkout and multiple payment options, including credit cards and cryptocurrency.

🔎 Product Specifications & Technical Data

To ensure your research parameters are met with precision, here are the verified technical specifications for our FGLs peptide. Purity is a critical determinant of research accuracy, and our product meets the high standards expected by the scientific community .

🧪 Key Research Applications & Focus Areas

FGLs peptide, as a selective NCAM mimetic, is a valuable tool across several advanced fields of neuroscience and cell biology.

• 🧠 Neuroregeneration & Neuroprotection: FGLs is extensively studied for its ability to promote neuronal survival and neurite outgrowth. By activating FGFR, it triggers signaling pathways (such as MAPK/ERK) that support neuronal health and regeneration after injury. Research indicates it can protect neurons from excitotoxic damage and promote functional recovery in models of CNS injury, including spinal cord injury and stroke .

• 🧬 Synaptic Plasticity & Cognitive Function: The NCAM-FGFR interaction is critical for long-term potentiation (LTP) , a cellular correlate of learning and memory. FGLs has been shown to enhance LTP and improve performance in various learning and memory tasks in animal models, including spatial memory and object recognition . This makes it a key compound for studying the molecular basis of cognitive function and potential interventions for cognitive decline .

• 🛡️ Neuroinflammatory Research: Emerging evidence suggests FGLs may possess anti-inflammatory properties within the CNS. By modulating glial cell activity, it could help create a more favorable environment for repair and plasticity, making it relevant for studying neurodegenerative and neuroinflammatory conditions like multiple sclerosis and Alzheimer's disease .

• 🧪 Cell Adhesion & Signaling Studies: FGLs serves as a precise molecular probe to dissect the specific role of NCAM-FGFR signaling in various cellular processes, independent of other functions of the full NCAM protein. Researchers use it to study cell migration, differentiation, and survival in both neuronal and non-neuronal cell lines .

🔬 How Does FGLs Work? (Mechanism of Action)

FGLs exerts its effects by mimicking a key functional domain of NCAM :

• Targeted Receptor Activation: The peptide is designed to bind specifically to the Fibroblast Growth Factor Receptor (FGFR) at the same site as the natural NCAM protein. This interaction acts as an agonist, activating the receptor .
• Intracellular Signaling Cascade: FGFR activation by FGLs triggers downstream signaling pathways, most notably the MAPK/ERK pathway and the phospholipase C gamma (PLCγ) pathway . These pathways are crucial for gene expression changes that promote neuronal survival, differentiation, and plasticity.
• Enhanced Plasticity: The resulting signaling events lead to enhanced synaptic plasticity, including the facilitation of long-term potentiation (LTP), which is essential for learning and memory formation .

📝 Handling, Storage, and Preparation for Research

Proper handling is critical to maintaining peptide integrity and ensuring experimental validity .

• Receiving & Storage: Upon receipt, store the lyophilized vial in a freezer at -20°C (-4°F) or below. Protect from light and moisture. Lyophilized FGLs is stable for up to 24 months under these conditions.
• Reconstitution: To prepare stock solutions, FGLs is soluble in sterile water. For in vivo studies, it is often reconstituted in artificial cerebrospinal fluid (CSF) or sterile PBS to match physiological conditions . Allow the peptide to warm to room temperature in a desiccator before opening. Gently swirl to dissolve; avoid vigorous vortexing to prevent denaturation.
• Dosage Considerations:
  • In vivo (Rodent): Preclinical studies often administer FGLs via intracerebroventricular (ICV) injection or systemic routes at doses ranging from micrograms per kilogram . Delivery rates are often precisely controlled using microinjection pumps .
  • In vitro: Concentrations in the nanomolar to low micromolar range are typically used in neuronal cell culture experiments.
• Safety & Handling: Always use personal protective equipment (PPE) such as gloves and safety goggles when handling. Work in a laminar flow hood or well-ventilated area. Dispose of all waste in appropriate sharps and biohazard containers.

❓ Frequently Asked Questions (FAQ)

Q1: What does FGLs stand for and what is its origin?

A: FGL stands for the FG Loop motif within the Neural Cell Adhesion Molecule (NCAM). The "s" denotes its dimeric structure . It is a synthetic peptide designed to mimic this specific part of NCAM, not extracted from natural sources.

Q2: What is the difference between FGL and FGLs?

A: FGL typically refers to the monomeric peptide sequence. FGLs is the dimeric form, where two of these sequences are linked together. This dimerization significantly increases its potency and stability as an NCAM mimetic .

Q3: How do I verify the quality of your FGLs?

A: We are committed to transparency. Our product listings provide access to a third-party Certificate of Analysis (COA) . This document validates the compound's identity via Mass Spectrometry (MS) and its purity via High-Performance Liquid Chromatography (HPLC), which is ≥98% .

Q4: Is FGLs a growth factor?

A: No, it is a peptide mimetic. It mimics the action of NCAM by binding to and activating the Fibroblast Growth Factor Receptor (FGFR), but it is structurally distinct from natural growth factors like FGFs .

Q5: What research areas is FGLs used for?

A: It is primarily used in neuroscience research, including studies on neuroregeneration, synaptic plasticity, learning and memory, neuroprotection, and neuroinflammation .

📦 Our Services & Guarantees

• 24/7 Customer Support: Our team is available to answer your pre- and post-sales questions.
• Authenticity Guarantee: We guarantee that you receive the exact product described, with full documentation and lot matching.
• Product Replacement: In the unlikely event of damage during shipping, we have a clear process for claims and replacement.
• Technical Consultation: Contact us for assistance with solubility or handling protocols.

🚀 How to Buy FGLs Peptide Online

Purchasing from buypeptidesonlineusa.com is simple and secure.

1. Browse & Select: Choose the quantity you need (e.g., 1mg, 5mg vial).
2. Add to Cart: Proceed to our secure checkout.
3. Payment: We accept major credit cards and cryptocurrency (Bitcoin, Ethereum, USDT) for privacy and convenience.
4. Shipping: Orders are processed within 24 hours on business days and shipped in discreet, temperature-controlled packaging. Domestic orders typically arrive in 2-5 days.

Ready to advance your neuroregeneration research? Add high-purity FGLs peptide to your cart today.