BUY PT-141 PEPTIDES FOR SALE ONLINE

What Is PT-141?

PT-141, also called bremelanotide, is sometimes referred to as the female Viagra because the peptide was previously investigated in phase IIb human clinical trials for use in treating female hypoactive sexual desire disorder (HSDD). PT-141 Peptides For Sale is a melanocortin that binds primarily to melanocortin 4 receptor (MC-4R) and MC-1R. In 2009, PT-141 was also investigated as a treatment for acute hemorrhage. PT-141 Peptides For Sale is a derivative of another synthetic melanocortin, melanotan 2 (MT-2).

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If this product does not meet your needs or interests, you may want to look at Melanotan 1 (MT1) 10mg. Please visit this link for further information on our Melanotan Peptides

PT-141 Molecular Structure

Source: PubChem

Sequence: Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)
Molecular Formula: C₅₀H₆₈N₁₄O₁₀
Molecular Weight: 1025.182 g/mol
PubChem CID: 9941379
CAS Number: 189691-06-3

PT-141 Research

PT-141 and Sexual Arousal

PT-141 Peptides For Sale is a unique peptide in that it stimulates the MC-4R, which is known to produce sexual arousal in the central nervous system and influence sexual behavior. Studies in mice have shown that agonist binding to MC-4R causes sexual arousal and increased copulation in both males and females. Because PT-141 works via a different mechanism than drugs like Viagra, it is possible to treat sexual arousal disorders in both men and women that stem from causes other than reduced blood flow to the genitals.

A study of men with erectile dysfunction (ED) who did not respond to sildenafil (Viagra) found that roughly one third experienced adequate erection for sexual intercourse with Bremelanotide PT-141 (administered via nasal spray). There was also a strong dose-dependent response in the trial, indicating that PT-141 Bremelanotide Research Peptide is indeed effective in certain cases. This suggests that PT-141 Peptides For Sale  could offer insight into correcting ED in settings where sildenafil has failed and may offer insight into central causes of hypoactive sexual desire.

Duration of penile base rigidity greater than 60% for placebo compared to various doses of PT-141.
Source: Nature

Interestingly, PT-141 was pulled from clinical trials before it reached approval for use in women suffering from HSDD. This is despite signs that the drug increased the number of satisfying sexual events per month and decreased female sexual distress scores in a statistically significant manner without any substantial side effects. Many experts who treat female sexual dysfunction (FSD) were dismayed to find the peptide was not being advanced despite positive results. They point to a lack of established endpoints for trials of FSD and sociocultural biases against women’s sexual health as the primary roadblocks that are inhibiting approval of what they see as much-needed therapies. They hope that greater attention will be given to the topic and that the FDA will establish more concrete guidelines for evaluating therapies like PT-141 Peptides For Sale that can offer benefit. These experts also expressed dismay that the pharmacological treatments were not tested in conjunction with other established means of treating sexual dysfunction as they believe that the combination may prove synergistic and that peptides like PT-141 may be useful for overcoming initial barriers and jump-starting psychological treatment modalities.

In 2017, partly in response to the outcry against the cessation of earlier trials, Phase II Reconnect trials were launched using subcutaneous injections of PT-141 for FSD. The newest version of PT141, called Rekynda, may soon be available for use in the United States. It would be legal to use PT 141 off-label, at that point, to treat both male and female sexual dysfunction. These new trials have relied on the kind of modified endpoints that experts in FSD have touted as beneficial to seeing these kinds of treatments approved.

PT-141 and Hemorrhage

In 2009, PT-141 was modified slightly and investigated as a potential treatment for hemorrhagic shock. Because PT-141 Peptides For Sale binds to both MC-1R and MC-4R, it reduces ischemia and protects tissues against inadequate blood supply in the setting of hypovolemic (hemorrhagic) shock. The drug, when administered intravenously, does not produce substantial side effects. It was last in phase IIb trials. The modified version of PT-141 is referred to as PL-6983.

PT-141 and Infection

The MC-1R has been found, in a rat model of a specific fungal infection, to possess important anti-fungal and anti-inflammatory properties. This is of particular importance because current anti-fungals are limited in terms of their mechanism of action and all produce serious and treatment-limiting side effects in certain patients. Having an alternative to use in the treatment of fungal infections could reduce morbidity and mortality substantially, especially in patients with immune compromise.

PT-141 and Cancer

The MC-1R receptor is an important stimulus of DNA repair pathways and thus is of interest in cancer treatment and prevention. Research shows that people with variants of MC-1R are at increased risk for both basal cell and squamous cell carcinoma. Altered PT-141 may be able to correct the problems experienced as a result of these variants and prevent or treat these cancers.

PT-141 and Weight Loss

Research shows that the MC-4R plays a critical role in appetite regulation. Peptides like melanotan 2 and PT-141, which are agonists of the MC-4R, promote feelings of satiety and decrease total calorie intake. It appears that PT-141 Peptides For Sale also interacts with leptin signaling pathways to regulate food intake in a complex manner. This should not come as a surprise given that PT-141 Peptides For Sale is a derivative of α-MSH, which has been found to negatively regulate food intake via interactions with the ghrelin-leptin system.

There is also evidence, from animal studies, to suggest that PT-141 increases energy expenditure by uncoupling certain energy pathways. This leads to an increase basal metabolism. Research in mice shows that activation of the MC-4R can increase thermogenesis, even in mice genetically modified to be deficient in the proteins that regulate this process. The result is increased calorie burn, even at rest, with most of the calorie burn taking place in adipose tissue.

Double-blind, randomized, placebo-controlled trials have recently supported the above physiological findings and have confirmed that PT-141 leads to significant weight loss, primarily as a result of decreased caloric intake. Subjects given PT-141 lost roughly twice as much weight as those in the placebo arm of the study. Overall, the caloric intake reduction amounted to nearly 400 kcal/day. There was also a dose-response in the research, with subjects losing more weight when administered PT-141 twice per day rather than once per day. PT-141 Peptides For Sale and its melanocortin receptor interactions are now under active investigation to better understand the role of the melanocortin system in weight loss and energy balance.

PT-141 Research Directions

Right now, PT-141  Peptides For Sale has received widespread and intense attention as a treatment for sexual dysfunction. There is, however, a great deal of potential research outside of sexual dysfunction and hemorrhage that PT-141 could be applied to. For instance, MC-4R is well-known to be defective or missing in certain cases of obesity and may account for as much as 6% of all cases of early-onset obesity. PT-141  Peptides For Sale offers a unique means of exploring this particular cause of obesity and potentially illustrating a pathway for intervention. MC-1R plays roles in both pain and inflammation, as well as kidney pathology and the spread of infection. There is a plethora of available research that PT-141 could help to shed light on.

PT-141 exhibits minimal side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. PT-141 Peptides for sale at USA Peptide Store is limited to educational and scientific research only, not for human consumption. Only buy PT-141 if you are a licensed researcher.

Buy Wholesale PT-141 From USA Peptide Store

At USA Peptide Store, our research peptides are of the highest purity and pharmaceutical grade. Our PT 141 peptide comes in 10mg vials as a crystalline powder that will need to be reconstituted before use. We’re passionate about our products, and we always strive to provide our customers with the best in both selection and quality. All of the products we provide are tested to verify authenticity and purity, so you can conduct your research with confidence.

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