Vialox Peptide (Pentapeptide-3V)

Welcome to Buy Peptides Online USA, your premier domestic source for high-purity, rigorously tested research compounds. Our Vialox Peptide (Pentapeptide-3V) is meticulously synthesized to meet the exacting standards of the modern laboratory. Below, we provide a comprehensive, evidence-based overview of this fascinating neuromuscular antagonist peptide.

🔬 What Is Vialox Peptide (Pentapeptide-3V)?

Vialox, scientifically designated as Pentapeptide-3V, is a synthetic pentapeptide characterized by the amino acid sequence Gly-Pro-Arg-Pro-Ala-NH₂ . Originally derived from the venom of the Temple Viper (Tropidolaemus wagleri), specifically the neurotoxin waglerin-1, Vialox is classified as a competitive antagonist of nicotinic acetylcholine receptors (nAChRs) .

Unlike invasive procedures that target neuromuscular junctions via injection, Vialox offers a topical research model for studying peripheral muscle relaxation. In the landscape of cosmetic research peptides, Vialox is frequently compared to Argireline (Acetyl Hexapeptide-8) and Syn-Ake; however, its unique pentapeptide structure and specific mechanism of action make it a distinct tool for dermatopharmacology and neuromuscular physiology .

⚠️ Important Research Notice: This product is strictly for non-human research, in vitro, and laboratory use only. It is not a drug, food, or cosmetic, and is not intended for human consumption or therapeutic application.

🧬 Peptide Structure & Technical Specifications

Understanding the molecular profile of Vialox is critical for proper experimental design. Below is the verified technical data sheet for our product:

🥇 Why Choose Buy Peptides Online USA?

When you decide to buy Vialox online USA, you are investing in data integrity. We bridge the gap between international manufacturing and domestic logistics to provide rapid delivery without compromising on quality.

• ✅ Certificate of Analysis (COA): Every batch of Pentapeptide-3V is accompanied by a detailed COA, verifying purity and concentration.
• 🔬 Dual Verification (HPLC + MS): We do not rely on single-method analysis. Our Vialox undergoes High-Performance Liquid Chromatography for purity quantitation and Mass Spectrometry for molecular weight confirmation .
• 🇺🇸 USA Domestic Shipping: Utilizing FedEx Priority/Overnight, your research materials arrive quickly and safely. We handle the chain of custody so you can focus on the bench work .
• 📦 Professional Packaging: Lyophilized powders are shipped in sterile, sealed vials, insulated with temperature-control packaging to preserve stability during transit.

⚙️ Mechanism of Action: How Does Vialox Work?

Vialox operates as a non-depolarizing neuromuscular blocker .

To understand its research value, one must look at the neuromuscular junction (NMJ). Typically, nerve impulses release acetylcholine (ACh) , which binds to nicotinic receptors on the postsynaptic membrane. This binding triggers sodium ion influx, depolarization, and subsequent muscle contraction.

Vialox acts as a competitive antagonist. It binds to these same nicotinic ACh receptors without activating them, effectively "blocking" the site. This prevents the natural neurotransmitter from binding, leading to a cessation of signal transmission and resultant muscle relaxation .

Quantitative Research Data:

• Contraction Reduction: Studies report that Vialox administration resulted in a 71% reduction in muscle contractions within one minute of exposure, sustaining a 58% reduction after two hours .
• Dermatological Metrics: Over a 28-day research model, Vialox was associated with a 49% reduction in wrinkle depth and a 47% decrease in dermal roughness .

🧪 Primary Research Applications

Pentapeptide-3V is not a one-dimensional tool. Its ability to selectively target peripheral nAChRs opens several avenues for investigation:

1. Dermatopharmacology & Mechanotransduction

Researchers utilize Vialox to study the link between micro-contractions of the dermal musculature and extracellular matrix (ECM) remodeling. By relaxing facial muscle models, scientists can observe collagen deposition and elastin behavior independent of invasive trauma .

2. Neuromuscular Physiology

As a probe for nAChR ligand-receptor dynamics, Vialox allows for the mapping of binding affinities and ion channel activation thresholds. Its pentapeptide size makes it ideal for structure-activity relationship (SAR) studies .

3. Comparative Toxicology

Derived from venom, Vialox serves as a model for studying the evolution of short peptide neurotoxins and their specificities for receptor subtypes .

4. Synthetic Biology

Vialox is frequently utilized in high-throughput screening assays to test receptor variants or to act as a scaffold for designing novel peptide libraries .

📝 Handling, Reconstitution, & Laboratory Use

Lyophilized State:
Our Vialox arrives as a lyophilized (freeze-dried) powder. In this state, it is highly stable. Do not open the vial until ready to use.

Reconstitution Instructions:

• Use sterile, deionized water (diH₂O) or sterile saline (0.9% NaCl).
• Bacteriostatic water is also acceptable for studies requiring extended use of a single vial.
• Gently swirl the vial. Do not shake vigorously, as this may introduce air bubbles and denature the peptide structure.

Dosage & Concentration:
Research concentrations vary widely based on the model. Typical in vitro concentrations range from 10 µM to 100 µM. Researchers are advised to conduct dose-response curves to determine optimal concentrations for their specific assay.

Storage After Reconstitution:
Peptides degrade rapidly in liquid form. Store reconstituted Vialox at 4°C for immediate use (up to 2 weeks) , or aliquot and store at -80°C for long-term stability .

❓ Frequently Asked Questions (FAQ)

Q: What is the difference between Vialox and Argireline?

A: While both target muscle contraction, Argireline (Acetyl Hexapeptide-8) inhibits SNARE complex formation to prevent vesicle fusion. Vialox (Pentapeptide-3V) acts directly at the post-synaptic receptor site, antagonizing acetylcholine directly. They represent two different classes of neuromuscular research peptides .

Q: Is the Vialox sequence shortened or full length?

A: We supply the full-length, bioactive Pentapeptide-3V (Gly-Pro-Arg-Pro-Ala). Some suppliers truncate sequences to reduce costs, resulting in inactive research. Our verification via MS confirms the correct molecular weight of 495.58 g/mol .

Q: Do you offer a Certificate of Analysis (COA)?

A: Yes. The COA, including HPLC chromatograms and MS spectrometry data, is available upon request or via download on the product page. We maintain strict lot traceability.

Q: How do you handle complaints or product issues?

A: We offer 24/7 Technical Consultation and a Product Replacement guarantee. If the purity falls below the specified >99% threshold, we will replace the product immediately.

🚚 Shipping, Payment, & Legal Compliance

Shipping:

• Carrier: FedEx Priority Overnight / 2Day.
• Handling: Orders placed before 2:00 PM EST typically ship same-day.
• International: Customers are responsible for all customs duties and taxes.

Payment Options:

We cater to the research community with flexible payment solutions:

• Credit Cards: Secure link payment via encrypted processor.
• Bank Transfers (ACH/Wire): Proforma invoice available.
• Purchase Orders (POs): Accepted from accredited Universities, Research Institutions, and Government agencies (NET 30 terms available upon credit approval) .

Legal Considerations:

Buy Peptides Online USA sells products exclusively for laboratory research and development purposes. By purchasing this product, you confirm that you are a qualified researcher or are acting on behalf of a qualified research institution. These products are not FDA-approved and are not intended for clinical or diagnostic use in humans or animals.

⭐ The Buy Peptides Online USA Advantage

We understand that your time and research outcomes are valuable. When you order Vialox Pentapeptide-3V from us, you aren't just buying a chemical; you are buying peace of mind.

• Authenticity Guarantee: Direct sourcing from GMP-compliant manufacturing facilities.
• Inventory Depth: Available in multiple sizes (from research grams to bulk quantities).
• Customer Support: Real scientists replying to your emails, not chatbots.
• Return & Refund Policy: Customer satisfaction is paramount. If we make a mistake, we fix it.

Ready to enhance your neuromuscular or dermatological research?

Purchase Vialox Peptide (Pentapeptide-3V) today and experience the difference in quality and service that has made Buy Peptides Online USA the trusted choice for researchers across the United States.