Vesilute Peptide

Unlock Cellular Resilience with Vesilute (Epitalon) Peptide: Premier Research Agent for Aging & Longevity Studies

Vesilute Peptide (Epitalon) represents a breakthrough in biogerontology research as a synthetic tetrapeptide analog of the natural pineal gland peptide Epithalamin. 🧬 This meticulously engineered 4-amino acid sequence (Ala-Glu-Asp-Gly) is designed for sophisticated laboratory investigations into telomere biology, cellular senescence, and epigenetic regulation of aging processes. Manufactured under cGMP standards and verified through HPLC-MS analysis, our premium-grade Vesilute offers researchers unparalleled purity (≥99%) and batch-to-batch consistency for reproducible experimental outcomes in longevity science.

🔬 Order Today for Premium Research Grade Vesilute: Experience the confidence of working with independently verified peptides, with free expedited shipping on all domestic US orders over $300 and discreet worldwide delivery options.

🔍 What Is Vesilute (Epitalon) Peptide?

Vesilute, scientifically referred to as Epitalon, is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) that mirrors the biological activity of the natural pineal peptide Epithalamin. This research compound has garnered significant attention in biogerontology laboratories worldwide for its potential to influence fundamental aging mechanisms at the cellular level. Unlike complex polypeptides with elaborate secondary structures, Vesilute’s elegant four-amino-acid design allows for precise investigation of peptide-mediated cellular communication pathways related to chronological regulation and homeostatic maintenance.

Originally developed as part of longevity science initiatives, Vesilute represents a paradigm shift in how researchers approach age-related physiological decline. The peptide’s molecular simplicity belies its sophisticated mechanism of action, which preliminary studies suggest involves epigenetic modulation and telomerase activation pathways. For research purposes, Vesilute serves as a valuable tool for exploring the interface between neuroendocrine signaling and cellular aging processes, particularly in models examining replicative senescence and mitochondrial function.

🧬 Vesilute Peptide: Molecular Architecture & Specifications

Peptide Structure & Chemical Profile

Vesilute features a linear tetrapeptide sequence with the amino acid arrangement: L-Alanyl-L-Glutamyl-L-Aspartyl-L-Glycine. This specific configuration creates unique physicochemical properties that influence its research applications and laboratory handling requirements:

• Primary Structure: Ala-Glu-Asp-Gly (AEDG)
• Molecular Formula: C₁₄H₂₂N₄O₉
• Molecular Weight: 390.35 g/mol
• Theoretical pI: 3.36
• Chemical Synonyms: Epitalon, Epithalon, Pinealon
• CAS Registry: 307297-39-8
• PubChem CID: 16132320

The peptide’s structure includes both acidic residues (glutamic acid and aspartic acid) that contribute to its hydrophilic character and influence its solubility profile in aqueous research buffers. The absence of complex folding requirements makes Vesilute particularly suitable for in vitro investigation of peptide-receptor interactions without concerns about tertiary structure denaturation.

Vesilute Peptide Specifications Table

For comprehensive research documentation and experimental planning, refer to the following technical specifications:

🧪 Certificate of Analysis & Quality Verification

Every batch of Vesilute peptide from Buy Peptides Online USA undergoes rigorous analytical validation to ensure research-grade integrity. Our quality assurance protocol includes multiple orthogonal analytical techniques that provide researchers with unprecedented transparency and confidence in their compounds.

High Performance Liquid Chromatography (HPLC) Analysis

Our HPLC validation employs reverse-phase chromatography with photodiode array detection to establish purity profiles and identify potential impurities. Each batch of Vesilute demonstrates ≥99% chromatographic purity with characteristic retention time consistency that confirms structural integrity. The HPLC methodology has been optimized specifically for tetrapeptide analysis, allowing detection of even trace synthetic byproducts that might interfere with experimental outcomes.

Mass Spectrometry (MS) Confirmation

Electrospray ionization mass spectrometry (ESI-MS) provides definitive confirmation of Vesilute’s molecular identity by verifying the exact mass-to-charge ratio corresponding to the theoretical molecular weight of 390.35 g/mol. The mass spectrometry data included in your Certificate of Analysis shows the characteristic [M+H]+ ion at m/z 391.3 and fragmentation patterns consistent with the Ala-Glu-Asp-Gly sequence, eliminating any uncertainty about peptide identity.

Accessing Your Certificate of Analysis

Upon request, researchers receive the complete batch-specific Certificate of Analysis documenting all quality control parameters. This analysis certificate includes chromatograms, mass spectra, and quantitative purity assessments performed by our independent third-party laboratory partners. We maintain digital archival of all COA documents for future reference and reproducibility documentation in research publications.

🎯 Primary Research Applications & Scientific Focus

Telomere Biology & Cellular Senescence Studies

Vesilute has emerged as a premier research tool for investigating the relationship between telomere dynamics and replicative lifespan. Laboratory studies employing Vesilute frequently examine:

• Telomerase activation mechanisms in various cell culture models
• Telomere length maintenance in replicating cell populations
• Senescence-associated secretory phenotype (SASP) modulation
• DNA damage response pathways in aging cellular systems

Circadian Rhythm & Neuroendocrine Research

Given its origin as a synthetic analog of pineal peptides, Vesilute provides unique opportunities to investigate:

• Melatonin synthesis regulation in pinealocyte cultures
• Circadian gene expression patterns (Clock, Bmal1, Per, Cry)
• Age-related changes in neuroendocrine communication
• Pineal-gonadal axis interactions in model organisms

Mitochondrial Function & Metabolic Studies

Research applications increasingly explore Vesilute’s potential influence on:

• Mitochondrial biogenesis and respiratory chain efficiency
• Reactive oxygen species management in aged cellular models
• Metabolic reprogramming associated with extended cellular viability
• ATP production optimization in stress-challenged systems

Epigenetic Regulation & Gene Expression

Advanced investigations utilize Vesilute to examine:

• DNA methylation patterns in age-related gene promoters
• Histone modification dynamics in senescent cells
• Transcriptional activity of longevity-associated genes (SIRT1, FOXO3, etc.)
• Chromatin remodeling in response to peptide stimulation

📋 Handling, Preparation & Laboratory Protocols

Reconstitution Guidelines for Research Use

Proper reconstitution technique is essential for maintaining Vesilute’s stability and ensuring experimental reproducibility:

1. Sterile Technique: Perform all handling in a laminar flow hood using aseptic methods
2. Solvent Selection: Use sterile bacteriostatic water, 0.9% saline, or appropriate research buffers
3. Reconstitution Volume: Add solvent slowly along the vial wall to prevent peptide aggregation
4. Gentle Mixing: Roll vial between palms—do not vortex or shake vigorously
5. Concentration Guidance: Typical research concentrations range from 1-10 mg/mL depending on application

Storage & Stability Considerations

• Lyophilized Form: Store unopened vials at -20°C ± 5°C protected from light
• Reconstituted Solution: Use immediately or store at 2-8°C for up to 7 days
• Long-Term Preservation: For extended storage (>1 month), aliquot and maintain at -80°C
• Freeze-Thaw Cycles: Avoid repeated freezing/thawing of reconstituted peptide

Experimental Dosing Considerations

While specific research protocols vary by experimental design, published methodologies typically utilize:

• In vitro applications: 1-100 μg/mL in cell culture media
• Animal model studies: 0.1-10 mg/kg body weight
• Administration frequency: Varies from single dose to daily administration for 5-30 days
• Control preparations: Always include vehicle-only controls in experimental designs

⚠️ Critical Laboratory Notice: Vesilute is provided exclusively for research purposes in controlled laboratory settings. This compound is not for human consumption, diagnostic use, or therapeutic application. Researchers must comply with all institutional biosafety guidelines and ethical oversight requirements when designing studies involving this or any research peptide.

📦 Packaging, Shipping & Support Services

Research-Grade Packaging

Each Vesilute order arrives with multiple protective layers ensuring peptide integrity:

• Primary Container: Sealed, nitrogen-flushed glass vial with rubber septum
• Secondary Protection: Light-resistant, impact-absorbing packaging
• Temperature Control: Insulated shipping with cold packs for temperature-sensitive transport
• Documentation Enclosure: Batch-specific information and handling instructions

Global Shipping Options

• USA Domestic: Free expedited shipping on orders over $300; 2-5 business day delivery
• International Research Communities: Worldwide shipping with customs documentation
• Discretion Assured: Plain, unmarked packaging without content identification
• Order Tracking: Real-time shipment monitoring from processing to delivery

Comprehensive Research Support

Our commitment extends beyond peptide supply to include:

• Technical Consultation: Access to scientific staff for protocol discussion
• Product Replacement: Assurance policy for verified shipping issues or damages
• Authenticity Guarantee: Third-party verification of all peptide identities
• 24/7 Order Support: Continuous access to order status and shipping information
• Complaint Resolution: Systematic approach to addressing researcher concerns

❓ Frequently Asked Questions: Vesilute Research Applications

Q: What distinguishes Vesilute from other peptides in aging research?

A: Vesilute’s unique value lies in its specific targeting of telomerase activation pathways and pineal-mediated circadian regulation—two fundamental mechanisms implicated in organismal aging. Unlike growth factors or metabolic peptides, Vesilute appears to influence epigenetic programming related to longevity, making it particularly valuable for geroscience investigations.

Q: How should I design appropriate controls for Vesilute experiments?

A: Rigorous experimental design should include: (1) Vehicle-only controls with identical reconstitution solvents, (2) Scrambled sequence controls when investigating sequence-specific effects, (3) Dose-response relationships across relevant concentration ranges, and (4) Time-course analyses to distinguish acute from chronic peptide effects.

Q: What analytical methods best confirm Vesilute activity in my research system?

A: Depending on your research focus, consider: qPCR for telomerase component expression (TERT, TERC), Southern blot or qFISH for telomere length assessment, RNA-seq for transcriptional profiling, immunoassays for melatonin pathway components, or functional assays of mitochondrial respiration.

Q: Are there specific cell lines or model organisms preferred for Vesilute research?

A: Published methodologies have employed human diploid fibroblasts (WI-38, IMR-90) for senescence studies, various cancer cell lines for telomerase investigations, pinealocyte cultures for circadian research, and multiple model organisms including mice, rats, and Drosophila for in vivo longevity assessments.

Q: How does Buy Peptides Online USA ensure batch-to-batch consistency?

A: We implement stringent quality control protocols including orthogonal analytical verification (HPLC, MS), reference standard comparison against authenticated samples, and biological activity screening in relevant assay systems when feasible.

🔬 Advancing Longevity Science with Premium Research Compounds

The field of biogerontology continues to evolve rapidly, with peptides like Vesilute providing crucial tools for deciphering the molecular basis of aging. As research uncovers more about epigenetic clocks, senolytic strategies, and metabolic determinants of longevity, the need for high-quality, well-characterized research compounds becomes increasingly paramount.

At Buy Peptides Online USA, we bridge the gap between peptide chemistry and aging biology by supplying rigorously verified research materials to the scientific community. Our Vesilute represents not just a chemical entity, but a key to potential discoveries in one of biomedicine’s most compelling frontiers.

Embark on your next groundbreaking investigation with the confidence that comes from working with independently verified, research-grade Vesilute peptide. Explore the boundaries of cellular longevity science with compounds you can trust, supported by documentation that meets publication standards.

Notice: All products from Buy Peptides Online USA are intended solely for laboratory research purposes by qualified professionals. These materials are not for human or veterinary diagnostic or therapeutic use. Researchers assume full responsibility for complying with all applicable regulations governing the handling and use of research compounds in their jurisdiction.