Tesofensine Peptide

⚖️ Introduction: Advanced Tool for Neuro-metabolic Research

At Buy Peptides Online USA, we introduce Tesofensine—a potent, centrally acting triple monoamine reuptake inhibitor with significant research applications in metabolic regulation, appetite control, and energy balance studies. Originally developed for neurodegenerative conditions and later investigated for weight management, Tesofensine represents a sophisticated research tool for investigating the neurochemical regulation of metabolism through simultaneous modulation of serotonin, norepinephrine, and dopamine pathways.

Our research-grade Tesofensine is synthesized to exceptional purity standards (≥99%) with comprehensive third-party analytical verification, providing researchers with a reliable, well-characterized compound for studying complex neuro-metabolic interactions. Unlike single-pathway agents, Tesofensine’s triple mechanism offers unique opportunities to investigate how combined neurotransmitter modulation affects feeding behavior, energy expenditure, and body composition in experimental models.

Important Classification Note 📝

While categorized with peptides in some contexts, Tesofensine is not a peptide—it is a small synthetic molecule with distinct chemical properties and mechanisms. This distinction is crucial for proper experimental design, handling, and interpretation of research findings.

🧪 What Is Tesofensine? Understanding This Triple Reuptake Inhibitor

Tesofensine (development code NS2330) is a potent, centrally acting inhibitor of the presynaptic reuptake transporters for three key neurotransmitters: serotonin (5-HT), norepinephrine (NE), and dopamine (DA). Chemically classified as a phenyltropane derivative, it represents a unique pharmacological profile among metabolic research compounds due to its balanced triple action.

Key Pharmacological Characteristics: 📊

• Chemical class: Phenyltropane derivative (small molecule, not peptide)
• Primary mechanism: Presynaptic monoamine reuptake inhibition
• Relative potency: NE > 5-HT > DA reuptake inhibition
• Research applications: Neuro-metabolic regulation studies

Comparative Neurotransmitter Effects: ⚖️

Mechanistic Distinction from Other Weight Management Research Compounds: 🔍

*Sibutramine was previously researched for weight management but is no longer widely available for clinical use in many countries.

📋 Complete Chemical Specifications & Quality Verification

Chemical Specifications Table 📋

Certificate of Analysis (COA) – Comprehensive Quality Documentation 📑

Each batch of our Tesofensine includes a detailed Certificate of Analysis (COA) documenting:

• HPLC purity analysis showing ≥99% main peak with chromatogram
• Mass spectrometry confirmation of molecular identity
• Nuclear Magnetic Resonance (NMR) spectroscopy confirming structure and stereochemistry
• Chiral HPLC verifying enantiomeric purity (>99%)
• Ultraviolet-visible spectroscopy confirming characteristic absorption
• Loss on drying determination (<0.5%)
• Residual solvent analysis per ICH guidelines
• Heavy metal screening (Pb, Cd, Hg, As < 2 ppm each)
• Microbiological testing (total aerobic count < 100 CFU/g)
• Endotoxin testing (<0.1 EU/mg where applicable)

Research Transparency: We provide batch-specific COA documentation to qualified researchers, ensuring complete analytical transparency.

🔬 Scientific Research & Potential Applications

Primary Research Mechanisms 🧠

1. Neurotransmitter Reuptake Inhibition:

• Serotonin (5-HT): Inhibition of serotonin transporter (SERT)
• Norepinephrine (NE): Inhibition of norepinephrine transporter (NET)
• Dopamine (DA): Inhibition of dopamine transporter (DAT)
• Synaptic effects: Increased extracellular monoamine concentrations

2. Metabolic Research Applications:

Appetite & Feeding Behavior Studies:

• Hypothalamic regulation: Effects on appetite centers (arcuate nucleus, PVN, LH)
• Satiety signaling: Enhancement of meal termination signals
• Food reward pathways: Modulation of hedonic feeding aspects
• Macronutrient selection: Potential effects on food preference

Energy Expenditure Research:

• Sympathetic activation: NE-mediated increases in metabolic rate
• Thermogenesis: Brown adipose tissue activation studies
• Physical activity: DA-mediated effects on spontaneous movement
• Adaptive thermogenesis: Prevention of metabolic adaptation to weight loss

3. Research Models & Experimental Approaches: 🐁

Current Research Landscape 📚

Tesofensine has been investigated in both preclinical and clinical research contexts:

• Phase II clinical trials: Demonstrated significant weight loss effects in human studies
• Mechanistic studies: Elucidated neurochemical and metabolic effects
• Comparative research: Versus other appetite/weight affecting agents
• Safety and tolerability: Profile established in controlled studies

Important Research Considerations: ⚠️

• Central vs. peripheral effects: Primarily CNS-mediated actions
• Dose-response relationships: Careful titration needed in research models
• Adaptive responses: Potential neurotransmitter system adaptations with chronic administration
• Species differences: Variable pharmacokinetics and metabolism across species

✅ Why Choose Our Research-Grade Tesofensine?

Uncompromising Quality Standards 🏆

Pharmaceutical-Grade Synthesis:

• ≥99% purity verified by analytical HPLC with chromatographic evidence
• Stereochemical purity >99% ensuring optimal pharmacological activity
• Batch-to-batch consistency for reproducible research outcomes
• Comprehensive impurity profiling with full characterization

Research-Specific Advantages:

• Triple mechanism: Unique pharmacological profile among research compounds
• Well-characterized: Substantial existing research literature for context
• Dosing flexibility: Suitable for various experimental designs
• Mechanistic insights: Opportunity to study neurotransmitter interactions

Service Excellence:

• Fast USA shipping – Most orders processed within 24-48 hours
• Complete documentation – Batch-specific COA with all analytical data
• Discreet packaging – Professional, research-appropriate presentation
• Research compliance – Strict adherence to laboratory-use guidelines

Comparative Research Value ⚖️

🌡️ Handling, Storage & Laboratory Protocols

Optimal Storage Conditions ❄️

• Primary storage: -20°C in airtight, light-resistant container with desiccant
• Working supply: 4°C for up to 30 days (minimize temperature fluctuations)
• Critical protection: Protect from light and moisture
• Solution stability: DMSO stock solutions stable at -20°C for 6+ months
• Avoid extremes: Protect from excessive heat (>40°C)

Preparation & Handling Guidelines 💊

1. Solution preparation: DMSO recommended for stock solutions
2. Dosing accuracy: Precise weighing due to potent activity
3. Administration routes: Oral gavage common in research models
4. Vehicle considerations: Appropriate controls for solvent effects
5. Stability documentation: Record preparation dates and storage conditions

Research Protocol Considerations 🐭

When designing studies with Tesofensine:

• Dose optimization: Wide initial range recommended (0.1-3.0 mg/kg in rodent models)
• Administration timing: Consider circadian metabolic rhythms
• Duration studies: Acute vs. chronic administration effects may differ
• Control groups: Vehicle controls essential, consider comparator agents
• Endpoint selection: Comprehensive metabolic and behavioral measures
• Adaptation monitoring: Potential tolerance or sensitization with chronic use

❓ Frequently Asked Questions (FAQS)

Q: Is Tesofensine a peptide?

A: No, Tesofensine is not a peptide. It is a small synthetic molecule belonging to the phenyltropane chemical class. Despite occasional categorization with peptides, it has completely different chemical properties, synthesis methods, and pharmacological mechanisms compared to peptides.

Q: How does Tesofensine’s triple mechanism differ from single reuptake inhibitors?

A: By simultaneously inhibiting serotonin, norepinephrine, and dopamine reuptake, Tesofensine affects multiple complementary pathways regulating appetite, energy expenditure, and reward/motivation. This integrated approach may produce different metabolic effects than agents targeting single neurotransmitter systems and better reflects the natural complexity of appetite regulation.

Q: What are appropriate dose ranges for Tesofensine in research models?

A: In rodent models, effective doses typically range from 0.1-3.0 mg/kg/day, with significant metabolic effects often observed at 0.25-1.0 mg/kg/day. However, optimal dosing should be determined empirically for specific research questions and model systems through careful pilot studies.

Q: How should Tesofensine solutions be prepared for research?

A: Prepare stock solutions in DMSO at concentrations appropriate for dosing (typically 10-100 mg/mL), then dilute with appropriate vehicle for administration. Aliquot stock solutions to avoid repeated freeze-thaw cycles, store at -20°C, and protect from light. Always include appropriate vehicle controls in experiments.

Q: What research endpoints are most relevant for Tesofensine studies?

A: Key endpoints include body weight and composition, food intake (total, meal patterns), energy expenditure (indirect calorimetry), locomotor activity, metabolic parameters (glucose, lipids, hormones), and neurochemical measures (microdialysis, receptor studies) for mechanistic investigations.

Q: How long do Tesofensine’s effects persist in research models?

A: Tesofensine has a relatively long half-life in preclinical models (approximately 8-12 hours in rodents), allowing once-daily administration in chronic studies. Effects on feeding behavior may be observed within hours, while significant metabolic effects typically develop over days to weeks with continued administration.

⚠️ Critical Compliance & Safety Information

Intended Use Statement 📋

Tesofensine is sold exclusively for laboratory research applications by qualified personnel in controlled settings. These products are:

• NOT for human or veterinary use
• NOT for consumption
• NOT intended as drugs, cosmetics, or dietary supplements
• NOT for diagnostic or therapeutic applications

Research Ethics & Design Considerations: ⚠️

• Neuroactive compound: Significant CNS effects require careful study design
• Dose-dependent effects: Potent activity necessitates precise dosing
• Chronic administration: Monitor for adaptive neurotransmitter system changes
• Behavioral effects: Consider impact on multiple behavioral domains beyond feeding

Regulatory Compliance: ⚖️

Researchers accept full responsibility for ensuring:

• All research complies with institutional guidelines and applicable regulations
• Materials are used only in approved laboratory facilities
• Documentation is maintained for all research purposes and protocols
• Safety protocols are followed for handling psychoactive compounds

🚀 Ordering & Research Support

Efficient Research Procurement 📦

1. Select Quantity – Based on research scope and experimental needs
2. Secure Checkout – Multiple payment options available
3. Fast Processing – Most orders ship within 1-2 business days
4. Complete Documentation – Batch-specific COA provided

Technical & Research Support 🔬

• Analytical documentation for all batches
• Research design consultation available
• Storage and handling guidance provided
• Compliance information for proper research use

💎 Research Value of Triple Reuptake Inhibition

For investigators exploring neuro-metabolic regulation, appetite control mechanisms, or central pathways in energy balance, Tesofensine offers a unique and valuable research tool. Its triple reuptake inhibition profile provides opportunities to study neurotransmitter interactions in metabolic control that single-mechanism agents cannot address.

With high purity, complete analytical characterization, and substantial research literature for context, Tesofensine provides a reliable tool for sophisticated metabolic neuroscience research that could advance understanding of feeding behavior, energy homeostasis, and potential approaches to metabolic disorders.

For laboratory research use only. Not for human consumption.