Syn-Coll (Palmitoyl Tripeptide-5)

🔬 What is Syn-Coll (Palmitoyl Tripeptide-5)?

Syn-Coll, chemically identified as Palmitoyl Tripeptide-5 (Pal-Lys-Val-Lys-OH), is a highly specialized cosmetic peptide classified as a “signal peptide.” Unlike carrier peptides (like GHK-Cu) or neurotransmitter-inhibiting peptides (like Syn-AKE), Syn-Coll is designed to communicate with fibroblasts at the genetic level .

At Buy Peptides Online USA, we supply this compound as a lyophilized, ultra-pure powder strictly for laboratory research and in-vitro formulation science. It is also known by the synonyms Pal-KVK or Palmitoyl Tripeptide-3 . Its primary value in research lies in its dual mechanism: stimulating procollagen synthesis while simultaneously arresting enzymatic collagen degradation.

If your laboratory requires a verified standard for TGF-β signal transduction research or dermal architecture studies, this is the definitive research compound to buy Syn-Coll peptide online in the USA.

🧬 Peptide Specifications & Chemical Structure

To maintain absolute research integrity, we provide the verified analytical fingerprint of our Syn-Coll batch. This is the minimum standard for high-purity research peptides USA .

🔎 Verified Quality: The 3-Layer Analytical Shield

At Buy Peptides Online USA, trust is earned through transparency. For researchers seeking to order Syn-Coll online, guessing the quality is not an option. Here is our mandatory verification protocol:

✅ High Performance Liquid Chromatography (HPLC): We utilize HPLC to quantify purity. Our Syn-Coll consistently tests at ≥99% , ensuring the absence of deletion sequences or incomplete palmitoylation .

✅ Mass Spectrometry (MS): MS confirms the exact molecular ion peak at 611.90 m/z . This verification confirms you are studying Pal-Lys-Val-Lys, not a truncated fragment .

✅ Certificate of Analysis (COA): Every lot includes a downloadable COA detailing retention time, purity percentage, and structural confirmation.

Why does this matter for your research? If the peptide structure is incorrect, your data on COL1A1/COL3A1 gene expression will be invalid. Our verification removes that variable.

⚙️ Mechanism of Action: How Does Syn-Coll Work?

Syn-Coll operates via the TGF-β (Transforming Growth Factor-Beta) pathway. This is its distinct differentiator in peptide science .

1. Mimicry: The peptide sequence mimics Thrombospondin-1, a natural protein that binds to the LAP (Latency Associated Peptide) .
2. Activation: This binding causes a conformational change, releasing active TGF-β from its latent complex.
3. Signal Transduction: Active TGF-β binds to its receptor on fibroblasts.
4. Gene Expression: This triggers the phosphorylation of Smad proteins, leading to nuclear transcription of Collagen Type I and Collagen Type III .

Secondary Mechanism (MMP Inhibition):
Simultaneously, Syn-Coll has been shown in studies to downregulate Matrix Metalloproteinases (MMP-1, MMP-3) —the enzymes responsible for collagen breakdown in photoaged skin .

Result: A net gain in dermal collagen density. This is why Syn-Coll is a primary standard in anti-degradation research.

🥼 Primary Research Applications & Typical Focuses

Syn-Coll is not a systemic hormone; it is a tissue-specific signaling molecule. Here are the validated fields of study:

1. 🧪 Dermatology & Extracellular Matrix (ECM) Remodeling
This is the primary application. Researchers utilize Syn-Coll to study the regeneration of the dermal extracellular matrix. Unlike growth factors which are mitogenic (cause cell division), Syn-Coll is cytostatic—it tells existing cells to work harder, not multiply faster. Studies cited by suppliers indicate significant upregulation of procollagen I (up to 160%) and procollagen III (up to 220%) in fibroblast cultures .

2. 🛡️ Anti-Inflammatory & Wound Healing Research
Due to its role in TGF-β activation (a key cytokine in wound healing), Syn-Coll is studied for macrophage polarization and granulation tissue formation. It is utilized in excisional wound models to measure re-epithelialization rates.

3. 🧬 3D Bioprinting & Tissue Engineering
Because Syn-Coll stimulates actual matrix production, it is often incorporated into hydrogel scaffolds and 3D bioprinted skin equivalents as a bioactive stabilizer.

4. 🧴 Transdermal Delivery Systems (Nanotechnology)
The palmitoyl group (C16 fatty acid chain) is a critical modification. Research indicates this lipophilic tail increases transdermal penetration by up to 3x compared to hydrophilic peptides, making it a benchmark molecule for studying liposomal encapsulation and microneedle delivery .

💼 Transactional: Why Buy Syn-Coll Peptide From Us?

When you order research peptides online USA, you need a partner, not just a supplier. Here is our commercial value proposition:

✅ Third-Party Verified: ≥99% purity via HPLC/MS. We publish our standards.
✅ Bulk & Wholesale Pricing: Available for high-throughput screening and formulation labs. Contact us for bulk quotes.
✅ US Stock, Same-Day Dispatch: Orders placed before 2:00 PM EST ship same day. No international customs delays.
✅ Authenticity Guarantee: If the COA doesn’t match the batch, we replace it immediately.
✅ Discreet & Climate-Controlled: Shipped in insulated liners with ice packs to protect the palmitoyl chain integrity.
✅ 24/7 Technical Support: Stuck on reconstitution? We offer real-time technical consultation.

❓ Frequently Asked Questions (FAQs)

Q: Is Syn-Coll the same as Matrixyl?

A: No. Matrixyl is Palmitoyl Pentapeptide-4. Syn-Coll is Palmitoyl Tripeptide-5. They have different sequences and different potencies regarding TGF-β activation. Syn-Coll is specifically noted for its high efficacy in inhibiting MMPs (collagenase) .

Q: What is the difference between CAS 623172-55-4 and 623172-56-5?

A: This is a common point of confusion. 623172-55-4 typically refers to the base compound. 623172-56-5 often refers to the trifluoroacetate (TFA) salt form or a specific derivative. Our product listing specifies the exact form; please refer to the COA for the precise stoichiometry .

Q: How do I reconstitute Syn-Coll for in-vitro studies?

A: As a water-soluble peptide, Syn-Coll dissolves readily in sterile deionized water (diH₂O) or sterile PBS (Phosphate Buffered Saline) . Allow the vial to come to room temperature, centrifuge briefly to collect the powder at the bottom, and add solvent. Swirl gently; avoid vigorous vortexing.

Q: What research concentrations are typically studied?

A: In cell culture (fibroblasts), effective concentrations are often observed in the μM range (1-10 µM). For topical formulation research, suppliers suggest testing ranges between 100ppm to 500ppm (0.01% – 0.05%) .

Q: Do you ship internationally?

A: Yes. We offer worldwide shipping. However, the buyer is responsible for understanding their local import regulations regarding research chemicals.

📦 Handling, Storage & Stability Protocols

Storage Guidelines:

• Lyophilized Powder: Stable for 24-36 months when stored at -20°C . Avoid humidity .
• Room Temperature: The product is stable during shipping (≤25°C) for up to 7 days, but immediate refrigeration upon receipt is required .
• In Solution: Unstable. Once reconstituted, the peptide is prone to hydrolysis and bacterial degradation. Aliquot immediately and store at -20°C. Discard after 1 month. Never refreeze a thawed aliquot .

Laboratory Safety:

⚠️ FOR RESEARCH USE ONLY. NOT FOR HUMAN OR VETERINARY USE.
This product is not FDA approved. It is not a medicine, nor a cosmetic for direct sale. It is a raw material for chemical and biological laboratory research purposes. By purchasing, the buyer confirms compliance with all local, state, and federal laws.

📦 Packaging, Shipping & Premium Services

📦 Our Packaging Protocol:

1. Vial Integrity: Sealed sterile vial inside a foil zip-lock bag with desiccant.
2. Cushioning: Anti-static bubble wrap to prevent vial fracture.
3. Thermal Control: Free Shipping on orders over $149. Includes insulated foam box + medical-grade ice packs.
4. Discretion: Plain outer box. No product labeling on the outside.

🛒 Post-Purchase Services:

• Product Replacement: If the vial arrives cracked or the peptide is denatured due to shipping failure.
• Authenticity Guarantee: Lot-specific COA matching.
• Complaint Handling: Dedicated support resolving issues within 24 business hours.
• Crypto Payments: Secure checkout using Bitcoin, Ethereum, and USDT.

🏆 Customer Testimonials

⭐⭐⭐⭐⭐ “Exactly as described. The MS spectra matched the theoretical mass of 611.9 Da perfectly. High-quality Syn-Coll for our dermal equivalent project.”
– Dr. M. T. (Tissue Engineering Lab)

⭐⭐⭐⭐⭐ “I’ve ordered from three different USA peptide sites. This is the only one where the COA actually matched the HPLC chromatogram. Will be a repeat buyer.”
– BioChem_RD (Verified Purchase)

⭐⭐⭐⭐⭐ “Fast shipping to California. The powder was a solid white plug, not a film on the glass. Excellent stability.”
– NanoFormulator