Syn-AKE Peptide

🔬 What is Syn-AKE Peptide? (The “Snake Venom” Analog)

Syn-AKE, scientifically known as Dipeptide Diaminobutyroyl Benzylamide Diacetate, is a synthetic biomimetic peptide designed to replicate the biological activity of Waglerin-1, a compound isolated from the venom of the Tropidolaemus wagleri (Temple Viper) .

Unlike actual venoms which are highly toxic, Syn-AKE is a refined, non-toxic, synthetic oligopeptide composed of a short chain of amino acids (Beta-Alanine, Proline, and Diaminobutyroyl Benzylamide). At Buy Peptides Online USA, we supply this peptide in its purest raw form strictly for laboratory research and in-vitro studies. It is classified as a neuro-active peptide due to its high affinity for muscle-type nicotinic acetylcholine receptors.

If you are looking to buy Syn-AKE peptide online for advanced topical formulation research or neuromuscular junction studies, our product offers the verified purity required for consistent, repeatable results.

🧬 Peptide Structure & Specifications

To ensure you are receiving research-grade material, we have compiled the verified analytical data for our Syn-AKE batch. This is the gold standard for researchers seeking high-purity peptides USA.

🔎 Verified Quality: HPLC, Mass Spectrometry & Certificate of Analysis (COA)

At Buy Peptides Online USA, we don’t just claim purity—we prove it. Every vial of Syn-AKE Peptide undergoes rigorous chemical validation.

✅ High Performance Liquid Chromatography (HPLC): We utilize HPLC to quantify the purity level. Our Syn-AKE consistently tests at ≥98% , ensuring the absence of truncated peptide sequences or synthesis by-products.

✅ Mass Spectrometry (MS): MS analysis confirms the precise molecular weight (495.58 Da) , verifying the structural integrity of the peptide. This ensures you are researching the exact antagonist required for nAChR studies.

✅ Certificate of Analysis (COA): A detailed COA is available upon request or via download on the product page, detailing retention times, peak purity, and mass confirmation.

Why does this matter for your lab? High purity eliminates variables. Whether you are studying muscle relaxation pathways or formulating next-gen cosmetic prototypes, our rigorous analytical validation ensures your data is reliable.

⚙️ Mechanism of Action: How Does Syn-AKE Work?

Syn-AKE operates via a unique neuro-antagonist pathway.

To understand its popularity in anti-aging research, one must look at the neuromuscular junction. Syn-AKE acts as a reversible antagonist specifically targeting the epsilon subunit of the muscle nicotinic acetylcholine receptor (nAChR) .

1. Receptor Binding: It binds competitively to the nAChR.
2. Channel Blockade: This binding prevents Acetylcholine (ACh) from activating the receptor.
3. Ion Inhibition: Subsequently, Sodium (Na+) ion influx is blocked.
4. Result: Depolarization is prevented, leading to muscle relaxation.

Research Application: This mechanism is primarily studied in the context of facial expression muscles (dynamic wrinkles) . Unlike Agonists that stimulate, Syn-AKE inhibits signal transmission, making it a critical tool in neuroscience and dermal pharmacology research .

🥼 Primary Research Applications & Typical Focuses

Syn-AKE is a specialized tool. It is not a systemic hormone or a growth factor; its utility is specific and potent. Here are the primary fields of study where Syn-AKE is utilized:

1. ⚡ Neuromuscular Research (Cognitive & Motor Function)
Researchers utilize Syn-AKE to study receptor-ligand interactions at motor endplates. It serves as a safer alternative to studying irreversible neurotoxins, allowing scientists to map acetylcholine receptor binding sites.

2. 💆‍♀️ Dermatology & Skincare Formulation Science
This is the most commercially significant application. Syn-AKE is a star ingredient in the “Needle-Free” movement. Studies cited by suppliers indicate that topical formulations containing Syn-AKE can lead to a 41-52% reduction in dynamic wrinkle density over 28 days by reducing micro-contractions of the facial muscles .

3. 🧪 Anti-Inflammatory Pathways
Emerging research suggests Syn-AKE may influence cytokine release in stressed dermal cells, contributing to a reduction in inflammation-induced aging (inflammaging).

4. 🔬 Cellular Delivery Systems
Due to its hydrophilic nature, Syn-AKE is frequently used in liposomal encapsulation and nano-emulsion research to study enhanced transdermal delivery methods .

💼 Why Buy Syn-AKE Peptide From Us? (Transactional & Trust Signals)

When you order research peptides online USA, you need a supplier that prioritizes discretion, speed, and scientific integrity. Here is why we are the preferred choice for buying Syn-AKE:

✅ Third-Party Verified: Every lot is tested via HPLC/MS. We don’t hide the batch data.
✅ Premium Packaging: You receive sterile, sealed vials with desiccant packs, ensuring peptide stability during transit.
✅ Rapid Shipping: Free Shipping on orders over $149. Discreet, climate-controlled packaging.
✅ US Stock, US Lab: No long customs delays. We maintain cold-stored inventory in domestic facilities.
✅ Authenticity Guarantee: If the COA doesn’t match, we replace it.
✅ 24/7 Technical Consultation: Have questions about reconstitution or solubility? Our peptide specialists are available.

❓ Frequently Asked Questions (FAQs)

Q: Is Syn-AKE the same as Botulinum Toxin?

A: No. This is a critical distinction. Botulinum Toxin (Botox) is an enzyme that cleaves SNARE proteins. Syn-AKE is a receptor antagonist. It blocks the receptor itself. It is a research chemical, not a drug. We supply it for in-vitro research only .

Q: How do I reconstitute Syn-AKE?

A: For laboratory use, thaw the vial to room temperature. Centrifuge briefly to collect powder at the bottom. Reconstitute with sterile deionized water (diH2O) or sterile PBS. Do not vortex vigorously; swirl gently.

Q: What is the recommended research dosage/concentration?

A: In formulation research, studies typically utilize concentrations ranging from 100ppm to 500ppm (0.01% – 0.05%) . For direct receptor assays, molarity calculations should be based on the 495.57 g/mol MW.

Q: Does Syn-AKE cause paralysis?

A: No. The binding mechanism is reversible and competitive. It relaxes tissue by raising the threshold for muscle contraction; it does not permanently disable the nerve.

Q: Do you offer wholesale or bulk pricing?

A: Yes. If you are a research institution or formulation lab needing bulk quantities, please contact our support team for a custom quote.

📦 Handling, Storage & Safety Protocols

Handling & Laboratory Use:

• Dispensing: Work in a laminar flow hood or clean environment.
• Hygiene: Wear appropriate lab gloves and safety goggles. Do not inhale dust particles.
• Cross Contamination: Use sterile spatulas or syringe needles for withdrawal.

Storage:

• Short Term: Store at 2-8°C (35-46°F) .
• Long Term: Store at -20°C (-4°F) .
• After Reconstitution: Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles as this degrades the peptide backbone.
• Stability: The lyophilized powder is stable for 24 months if kept in the original moisture-proof bag.

Legal & Safety Notes:

⚠️ FOR RESEARCH USE ONLY. NOT FOR HUMAN OR VETERINARY USE.
This product is not FDA approved. It is not a medicine, pharmaceutical drug, or cosmetic. This peptide is sold strictly for chemical and biological laboratory research purposes. By purchasing, the buyer confirms compliance with all local, state, and federal laws regarding the handling of research chemicals.

🚚 Shipping, Packaging & Services

We understand that peptide integrity is fragile. Heat and movement degrade raw material.

📦 Our Packaging Protocol:

1. Vial: Sealed sterile vial inside a protective poly-bag.
2. Cushion: Bubble wrap or foam padding to prevent vial fracture.
3. Thermal: Ice packs and insulated liners for temperature stability.
4. Discretion: Shipments are sent in plain boxes labeled only for shipping address.

🛒 Our Commitment to You:

• Product Replacement: If your vial arrives compromised or degrades within the shelf life due to our handling, we replace it.
• Authenticity Guarantee: We fight counterfeit raw materials.
• Complaint Handling: Human support, not bots. We resolve shipping or quality issues within 24 hours.

🏆 Customer Testimonials

⭐⭐⭐⭐⭐ “Consistent quality. The MS data matched the COA perfectly. Will order Syn-AKE again for our dermal study.” – Dr. R. K. (Biotech R&D)

⭐⭐⭐⭐⭐ “Finally a US supplier with real HPLC verification. Shipping was fast; the peptide arrived as a solid plug, not degraded powder.” – The Peptide Chemist (Verified Buyer)

⭐⭐⭐⭐⭐ “I use this for cosmetic formulation research. The purity is evident when reconstituted—no cloudiness, perfectly clear solution.” – Nico L.