SNAP-8 Peptide
$155.00
🧠🔬 High-purity SNAP-8 Peptide CAS 868844-74-0. ≥98% HPLC/MS. The advanced SNARE complex inhibitor octapeptide. 30% enhanced efficacy vs. hexapeptide analogs. USA lab stock. 🇺🇸 Order now.
🧪 What Is SNAP-8 Peptide? The Verified Molecular Identity
SNAP-8 (Acetyl Octapeptide-3; CAS 868844-74-0) is a synthetic octapeptide engineered as a competitive inhibitor of the SNARE complex—the conserved ternary protein machinery responsible for vesicle docking and neurotransmitter exocytosis at the neuromuscular junction .
THIS IS THE CORRECT MOLECULAR ENTITY FOR SNARE COMPLEX INHIBITION RESEARCH.
Molecular Definition:
| Property | Specification |
|---|---|
| Sequence (Full) | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂ |
| Sequence Shortening | Ac-EEMQRRAD-NH₂ |
| CAS Number | 868844-74-0 ✅ |
| Molecular Formula | C₄₁H₇₀N₁₆O₁₆S |
| Molecular Weight | 1075.16 g/mol |
| IUPAC Name | (4S)-4-acetamido-5-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-carboxy-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid |
| InChI Key | KMACPCJUCHVVGP-UHFFFAOYSA-N |
| Synonyms | Acetyl Octapeptide-3; Acetyl Glutamyl Heptapeptide-3; SNAP-8; Ac-EEMQRRAD-NH₂; N-Acetyl-L-α-glutamyl-L-α-glutamyl-L-methionyl-L-glutaminyl-L-arginyl-L-arginyl-L-alanyl-L-α-asparagine |
Why SNAP-8 Is Scientifically Distinct:
SNAP-8 represents the engineered evolution of neurotransmitter-inhibiting peptide technology :
| Parameter | Argireline® (Acetyl Hexapeptide-3) | SNAP-8 (Acetyl Octapeptide-3) |
|---|---|---|
| Peptide Length | Hexapeptide (6 amino acids) | Octapeptide (8 amino acids) |
| Sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-NH₂ | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂ |
| CAS Number | 616204-22-9 | 868844-74-0 |
| Molecular Weight | ~889 Da | 1075.16 Da |
| SNARE Complex Inhibition | Competitive inhibition | Enhanced competitive inhibition |
| Relative Efficacy | Baseline (100%) | ≈130% (30% greater activity) |
| Wrinkle Depth Reduction | Documented | Up to 63.13% (clinical) |
The Structural Rationale:
The addition of C-terminal Alanine-Aspartic acid (Ala-Asp) extends the SNAP-25 mimetic domain, potentially providing additional binding contacts with Syntaxin and VAMP within the SNARE complex assembly site . This elongation enhances competitive displacement of native SNAP-25 without increasing cytotoxicity .
What SNAP-8 IS (Verified):
- ✅ A synthetic octapeptide mimic of the N-terminal domain of SNAP-25
- ✅ A competitive inhibitor of SNARE complex assembly
- ✅ A neurotransmitter release modulator (acetylcholine)
- ✅ A non-invasive, non-neurotoxic research tool for neuromuscular junction studies
- ✅ A 30% more potent analog compared to first-generation hexapeptides
What SNAP-8 IS NOT:
- ❌ NOT Botulinum toxin (does NOT enzymatically cleave SNARE proteins)
- ❌ NOT a muscle relaxant (does NOT block postsynaptic acetylcholine receptors)
- ❌ NOT interchangeable with Argireline (different sequence, different efficacy profile)
- ❌ NOT a collagen-stimulating matrix peptide
- ❌ NOT a copper-binding peptide
⚠️ STRICT RESEARCH USE ONLY: Not for human consumption, injection, topical application, or cosmetic formulation. For in vitro and ex vivo laboratory experimentation exclusively.
⚗️ SNAP-8: Verified Technical Specifications
Precision neuropharmacology research demands reagents of verified identity, defined stereochemistry, and documented purity. Below is the complete analytical profile for our SNAP-8, verified against CAS 868844-74-0 and PubChem data .
Every batch is accompanied by a lot-specific Certificate of Analysis (COA) with raw HPLC chromatograms and MS spectra. 📊✅
📋 Peptide Specifications Table
| Specification | Detail | Verification Source |
|---|---|---|
| Sequence (Full) | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂ | |
| Sequence (One-Letter) | Ac-EEMQRRAD-NH₂ | |
| CAS Number | 868844-74-0 ✅ | |
| Molecular Formula | C₄₁H₇₀N₁₆O₁₆S | |
| Molecular Weight | 1075.16 g/mol | |
| Exact Mass | 1074.48 Da | Calculated |
| PubChem CID | 101336260 (related) | |
| InChI Key | KMACPCJUCHVVGP-UHFFFAOYSA-N | |
| Density | 1.56 g/cm³ (predicted) | |
| Purity (HPLC) | ≥98.0% | |
| Counter Ion | Acetate or TFA (specify on COA) | Standard |
| Peptide Content | ≥80% (net peptide weight) | |
| Appearance | White to off-white lyophilized powder | |
| Solubility | HPLC-grade water (10 mg/mL); PBS, DMSO | |
| Water Content (Karl Fischer) | ≤10.0% | |
| Acetate Content | ≤15.0% (if acetate salt) | |
| Amino Acid Composition | ±10% of theoretical | |
| Mass Balance | 95.0–105.0% | |
| Storage (Lyophilized) | -20°C (-4°F) ; Desiccated; Light-protected | |
| Storage (Solution) | Aliquot immediately; -80°C; NO freeze-thaw cycles | Standard |
| Shelf Life | 24 months (unopened, -20°C) | Standard |
| Quality Verification | HPLC (purity), MS (identity), Amino Acid Analysis (stoichiometry), Karl Fischer (moisture) | |
| Manufacturing Standard | GMP-compliant facilities; ISO 9001:2015 guidelines | Standard |
| Intended Application | In vitro and ex vivo research use only |
🔬 How Does SNAP-8 Work? The SNARE Complex Inhibition Mechanism
SNAP-8 operates via a competitive inhibition mechanism targeting the SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment Protein Receptor) complex—the conserved molecular machinery responsible for vesicle docking and neurotransmitter exocytosis .
1. 🧲 Molecular Mimicry: The SNAP-25 N-Terminal Domain
SNAP-8 is rationally engineered to precisely mimic the N-terminal domain of SNAP-25 (Synaptosomal-Associated Protein of 25 kDa) —a critical t-SNARE protein localized to the presynaptic plasma membrane .
The Native SNARE Complex:
- Proteins Involved: VAMP (vesicle-associated membrane protein; on vesicle membrane), Syntaxin (on target membrane), and SNAP-25 (on target membrane)
- Assembly: These three proteins coil into a stable four-helix bundle that physically pulls the vesicle and plasma membranes together
- Outcome: Membrane fusion → neurotransmitter (acetylcholine) release into synaptic cleft → muscle contraction
2. ⚡ Competitive Inhibition: Displacement of Native SNAP-25
SNAP-8 functions as a competitive antagonist :
- Recognition: The octapeptide sequence is recognized by Syntaxin and VAMP as a legitimate binding partner
- Occupation: SNAP-8 occupies the spatial position and binding sites normally filled by native SNAP-25
- Destabilization: The truncated peptide cannot fully stabilize the four-helix bundle, resulting in a partially formed, dysfunctional SNARE complex
- Functional Consequence: Reduced vesicle fusion efficiency → attenuated acetylcholine release → decreased muscle contraction amplitude
📌 Critical Mechanistic Distinction:
| Agent | Mechanism | Molecular Action |
|---|---|---|
| Botulinum Toxin (Botox) | Enzymatic cleavage | Proteolytically degrades SNAP-25; irreversible until protein resynthesis |
| SNAP-8 | Competitive inhibition | Reversibly competes for binding sites; modulates, not destroys |
3. 🧪 Quantitative Efficacy: 30% Enhancement Over Hexapeptide
Peer-reviewed comparisons demonstrate:
"SNAP-8 was developed as an elongation of Argireline, with the addition of two amino acids. This structural modification was investigated for its potential to increase the peptide's ability to disrupt the SNARE complex… some research suggesting that SNAP-8 may be approximately 30% more active than its parent peptide."
Clinical Documentation:
- Wrinkle depth reduction: Up to 63.13% in clinical studies
- Time course: Significant reduction observed at 28–30 days
- Dose-response: Formulations containing 3–10% SNAP-8 demonstrate efficacy
4. 🧬 Molecular Architecture & Stability Features
N-Terminal Acetylation:
- Neutralizes positive charge at N-terminus
- Enhances proteolytic resistance to aminopeptidases
- Mimics native protein conformation
C-Terminal Amidation:
- Removes negative charge at C-terminus
- Increases membrane penetration potential
- Extends experimental half-life
Methionine Residue:
- Oxidation-sensitive (Met → Met sulfoxide)
- Requires nitrogen-purged storage and reducing conditions for long-term stability
🧫 Primary Research Applications & Typical Research Focuses
SNAP-8 is not a "cosmetic ingredient" in our supply chain—it is a precision molecular tool for investigating SNARE complex dynamics, vesicle fusion mechanisms, and neuromuscular junction physiology .
🧠 1. Neuropharmacology & SNARE Complex Research
- SNARE complex assembly/disassembly kinetics: FRET-based assays; reconstituted liposome fusion models
- Competitive binding studies: Surface plasmon resonance (SPR); microscale thermophoresis (MST)
- Structure-activity relationships (SAR): Alanine scanning; truncation analogs
- SNAP-25 domain mapping: Identifying minimal functional motifs
🔬 2. Neuromuscular Junction & Synaptic Transmission
- Primary neuronal culture: Hippocampal or cortical neurons; whole-cell patch clamp recording of mEPSCs
- Neuromuscular junction (NMJ) explants: Phrenic nerve-hemidiaphragm preparation; quantal content analysis
- Acetylcholine release quantification: Choline oxidase-based amperometry; ELISA
- Calcium imaging: Fluo-4/AM; depolarization-evoked Ca²⁺ influx
🧪 3. Comparative Efficacy Studies (Peptide Benchmarking)
- Head-to-head comparisons: SNAP-8 vs. Argireline vs. Leuphasyl vs. Vialox
- Dose-response normalization: EC₅₀ determination across peptide classes
- Synergy studies: Combination indices (CI) with other neurotransmitter inhibitors
- Cytotoxicity profiling: MTT/LDH in relevant cell lines
💊 4. Formulation & Delivery Science
- LC-MS/MS method development: Quantification of SNAP-8 in complex matrices; MRM transition optimization
- Stability-indicating methods: Forced degradation (oxidation, hydrolysis, thermal)
- Penetration enhancement: Liposomal encapsulation; microneedle delivery systems
- Release kinetics: Franz cell diffusion; Strat-M® membranes
📄 Certificate of Analysis (COA) & Quality Verification Protocol
Why "≥98%" Is Non-Negotiable for SNARE Complex Research. 🎯
SNAP-8 presents specific analytical challenges due to:
- Methionine oxidation: Susceptible to sulfoxide formation; alters mass and bioactivity
- Multiple charged residues: Six acidic/basic amino acids; challenging chromatography
- Sequence length: Octapeptide requires optimized gradient conditions for impurity resolution
- C-terminal amidation: Must verify complete amidation vs. free acid
Lower-purity sources (<95%) from non-verified vendors frequently contain:
| Impurity Type | Identity | Experimental Consequence |
|---|---|---|
| Methionine sulfoxide | [Met(O)] | Altered binding affinity; false-negative EC₅₀ |
| Deletion sequences | Des-Ala, Des-Asp, Des-Arg | Reduced competitive inhibition; underestimates potency |
| Truncated fragments | Ac-EEMQR-NH₂ (etc.) | Partial agonist/antagonist activity; confounded data |
| Free acid (C-terminal) | …-Asp-OH vs. …-Asp-NH₂ | Reduced membrane penetration; altered charge |
| Acetylation failure | H-EEMQRRAD-NH₂ | Reduced stability; altered retention time |
Our ≥98% specification with documented oxidation control ensures you are testing the INTENDED molecular entity (CAS 868844-74-0).
📈 High Performance Liquid Chromatography (HPLC)
- Instrument: Waters Alliance e2695 / Agilent 1260 Infinity II
- Column: BetaBasic-18, 5 µm, 4.6 × 250 mm (optimized for polar peptides)
- Mobile phase: 0.1% TFA in H₂O (A) / 0.1% TFA in acetonitrile (B)
- Gradient: 0–40% B over 25 min (optimized for SNAP-8 resolution)
- Flow rate: 0.3 mL/min
- Detection: PDA @ 214 nm (peptide bonds) & 280 nm (minimal)
- Column temperature: 40°C
- Autosampler temperature: 4°C
- Injection: 10 µL of 1 mg/mL solution in HPLC-grade water
- Acceptance Criteria:
- Main peak area ≥98.0%
- Resolution of Met(O) species ≥1.5 (if present; target 0%)
- Single principal peak with symmetrical shape
🎯 Mass Spectrometry (MS)
- Method: ESI-TOF (Electrospray Ionization Time-of-Flight), positive mode
- Expected [M+H]⁺: 1076.16 m/z
- Expected [M+2H]²⁺: 538.58 m/z
- Expected [M+3H]³⁺: 359.39 m/z
- Expected [M+Na]⁺: 1098.14 m/z
- Acceptance Criteria:
- Mass accuracy ±0.5 Da
- NO peak at +16 Da (absence of methionine sulfoxide)
- NO peak at -71 Da (absence of des-Ala)
- NO peak at -115 Da (absence of des-Asp)
- Consistent isotopic distribution
🧬 Amino Acid Analysis (AAA)
- Method: HCl hydrolysis (110°C, 24 hr); pre-column derivatization; RP-HPLC
- Expected molar ratios:
- Glutamic acid (2.0; Glu)
- Methionine (1.0; Met; partial degradation expected)
- Glutamine (1.0; converted to Glu)
- Arginine (2.0; Arg)
- Alanine (1.0; Ala)
- Aspartic acid (1.0; Asp)
- Acceptance Criteria: All stable residues within ±10% of theoretical
💧 Additional QC Parameters
- Appearance: Visual inspection—white, free-flowing powder, no discoloration
- Solubility test: Clear, colorless solution in HPLC-grade water at 10 mg/mL
- pH (1% solution): 4.5–6.5 (acetate salt); 2.0–4.0 (TFA salt)
- Residual solvents: GC headspace; complies with ICH Q3C
- Mass balance: 95.0–105.0%
Your downloadable COA includes:
- ✅ Annotated HPLC chromatogram (integration markers, impurity profiling)
- ✅ Raw MS spectra (annotated adduct peaks, isotopic distribution, oxidation check)
- ✅ AAA stoichiometry table with experimental vs. theoretical ratios
- ✅ Certificate of Authenticity with QC Manager digital signature
- ✅ Batch-specific stability data
We actively encourage independent third-party verification. 🛡️
❓ Frequently Asked Questions (FAQs)
1. Is SNAP-8 the same as Argireline (Acetyl Hexapeptide-3)?
NO. THIS IS A CRITICAL DISTINCTION. 🚫
| Parameter | Argireline® | SNAP-8 |
|---|---|---|
| Peptide Length | 6 amino acids | 8 amino acids |
| Sequence | Ac-EEMQRR-NH₂ | Ac-EEMQRRAD-NH₂ |
| CAS | 616204-22-9 | 868844-74-0 |
| MW | ~889 Da | 1075.16 Da |
| Relative Activity | Baseline | ≈130% (30% greater) |
SNAP-8 IS THE ENGINEERED ELONGATION OF ARGIRELINE. The addition of Ala-Asp confers enhanced competitive inhibition. They are NOT interchangeable.
2. Is SNAP-8 the same as Botox?
NO. FUNDAMENTALLY DIFFERENT MECHANISMS.
| Agent | Mechanism | Duration | Invasiveness |
|---|---|---|---|
| Botulinum Toxin | Enzymatic cleavage of SNAP-25 | Months | Injected |
| SNAP-8 | Competitive inhibition of SNARE assembly | Hours–Days | Topical/research |
SNAP-8 DOES NOT CLEAVE OR DEGRADE SNAP-25. It reversibly competes for binding sites. It is non-neurotoxic, non-paralytic, and fully reversible .
3. What purity do I need for SNARE complex binding assays?
≥98% IS MANDATORY FOR PUBLICATION-QUALITY DATA.
Lower-purity batches (95–97%) from non-verified sources consistently contain:
- Oxidized methionine (Met(O)) → altered conformation → reduced binding affinity
- Deletion sequences → competitive inhibition heterogeneity → confounded EC₅₀
- Truncated fragments → partial agonist activity → unreproducible data
Our ≥98% specification with documented oxidation control ensures you are testing the INTENDED molecular entity.
4. How do I reconstitute SNAP-8?
EXCELLENT AQUEOUS SOLUBILITY. Unlike acylated lipopeptides, SNAP-8 is hydrophilic and freely soluble in aqueous buffers.
Reconstitution protocol:
- Centrifuge vial briefly (5,000 × g, 10 sec) to ensure pellet at bottom.
- Add sterile HPLC-grade water, PBS (pH 7.4), or cell culture media (10 mg/mL).
- Vortex gently 30–60 seconds until optically clear.
- Aliquot immediately into single-use vials.
- Store at -80°C for long-term stability (>6 months).
- AVOID freeze-thaw cycles. Discard unused working solution.
LC-MS/MS diluent: HPLC-grade water containing 0.1% formic acid .
5. How stable is reconstituted SNAP-8?
- Lyophilized powder: 24 months at -20°C (desiccated, light-protected, nitrogen-purged)
- In water/PBS (frozen): 6 months at -80°C; 1 month at -20°C (single-use aliquots)
- In water/PBS (4°C): <7 days (risk of bacterial growth; peptide stable but solution not sterile)
- At room temperature: <24 hours
- Critical: Methionine oxidation accelerates in solution. Minimize oxygen exposure. Use reducing agents (DTT, TCEP) if compatible with assay.
6. What is the documented wrinkle reduction percentage?
UP TO 63.13% in clinical studies .
"One study noted a maximal reduction in wrinkle depth of up to 63.13% in subjects."
Comparative data:
- 28 days: 17–30% reduction
- 30 days: Statistically significant reduction vs. placebo
- Superior to hexapeptide: Approximately 30% greater activity
7. Does SNAP-8 require special formulation for cell culture?
NO. SNAP-8 is directly soluble in aqueous cell culture media.
Recommended working concentrations:
- In vitro (primary neurons, cell lines): 10–100 µM
- Ex vivo (tissue explants): 50–200 µM
- Formulation research: 3–10% (w/w)
Always perform cytotoxicity controls (MTT, LDH) for your specific cell type and exposure duration.
8. What is the difference between TFA salt and acetate salt?
| Salt Form | Properties | Recommended Use |
|---|---|---|
| TFA (Trifluoroacetate) | Standard HPLC purification salt; enhances solubility; may affect sensitive cell assays at high concentrations | Biochemical assays; HPLC standards; acute exposures |
| Acetate | Biocompatible; preferred for cell culture; reduced cytotoxicity | Cell culture; primary neurons; chronic exposures |
Specify your preferred salt form at checkout. Default is TFA unless otherwise requested.
9. Can SNAP-8 be combined with other neurotransmitter inhibitors?
YES. SYNERGY IS DOCUMENTED.
SNAP-8 (SNARE complex inhibition) operates via a distinct molecular node from:
- Leuphasyl (Pentapeptide-18): δ-opioid receptor agonist; presynaptic calcium channel modulation
- Vialox (Pentapeptide-3): Postsynaptic nAChR antagonist
- Syn-Ake: Nicotinic acetylcholine receptor antagonist
Combination Index (CI) studies suggest synergistic inhibition when targeting multiple nodes of the neuromuscular signaling cascade.
10. Is SNAP-8 approved for cosmetic use?
THIS IS A RESEARCH REAGENT. NOT FOR COSMETIC USE.
SNAP-8 is generally recognized as safe (GRAS) for cosmetic applications when manufactured to cosmetic-grade specifications . Our material is RESEARCH-GRADE, not cosmetic-grade. It is sold EXCLUSIVELY for laboratory research use.
📦 Packaging, Shipping & Laboratory Handling
📦 Packaging Specifications
- Primary container: 2 mL or 5 mL Type I borosilicate glass vial (USP/EP certified), nitrogen-purged to prevent methionine oxidation
- Closure: Bromobutyl rubber stopper (low heavy-metal, latex-free), aluminum crimp seal with flip-off cap
- Headspace: Nitrogen-purged; oxygen absorber included in secondary packaging
- Secondary packaging: Foil laminate zip-seal bag with indicating desiccant (cobalt-free)
- Labeling: Amber-resistant label with CAS 868844-74-0, MW 1075.16, sequence Ac-EEMQRRAD-NH₂, lot number, storage conditions, and "FOR RESEARCH USE ONLY"
🚚 Shipping Conditions (USA Domestic)
- Carrier: FedEx Priority Overnight / 2Day (signature required)
- Thermal protection: Polar packs (≤-20°C during transit) for peptide integrity; DO NOT ship at ambient
- Transit time: 2–5 business days (contiguous USA)
- International: FedEx International Priority; buyer responsible for local duties, taxes, and import permits
🧤 Laboratory Handling & Safety
- PPE required: Nitrile gloves, lab coat, safety eyewear
- Ventilation: Standard laboratory ventilation sufficient
- Decontamination: 70% ethanol
- Spill management: Absorb with inert material; dispose as chemical waste
🛡️ Why Choose Buy Peptides Online USA? (Transactional Value Proposition)
We do not sell "cosmetic ingredients." We supply analytically verified research reagents to qualified laboratories. Here is why experienced neuropharmacology investigators choose us—and keep choosing us: 🏆
✅ Authenticity Guarantee (No Fine Print)
If the HPLC/MS/AAA data does not match the stated specifications (including CORRECT CAS NUMBER 868844-74-0, CORRECT MOLECULAR WEIGHT 1075.16 Da, and DOCUMENTED ABSENCE of methionine oxidation >1%), you receive:
- Full replacement (expedited, 2-day air) OR
- 100% refund (no restocking fee, no return shipping cost, no questions asked)
🔬 Technical Consultation (24/7)
Our support team consists of PhD-level scientists who understand peptide chemistry, SNARE complex biology, AND the critical distinction between SNAP-8 and Argireline.
- Not chatbots. Not script readers. Not outsourced.
- Ask about: Methionine oxidation control, SNARE complex assay design, solubility in specialized buffers, combination index studies
- Response time: <2 hours (business hours); <12 hours (after hours)
- Direct email: science@buypeptidesonlineusa.com
💰 Flexible Payment Options
- Credit cards: VISA, MC, AMEX, Discover (Stripe PCI-DSS Level 1, tokenized)
- Cryptocurrency: Bitcoin, Ethereum, USDT (ERC-20/Tron) → +5% discount
- Bank wire: Available for institutional purchase orders (NET 15 for qualified academic institutions with approved credit)
- Purchase orders: Accepted from universities, research institutions, and government agencies (NET 30)
📦 Rapid Fulfillment
- Same-day shipping for orders placed before 2:00 PM EST (Mon–Fri)
- Real-time inventory—no backorders on in-stock items
- Bulk quotes available for >1 gram quantities (5g, 10g, 25g, 50g, 100g+)
- Standing purchase agreements (SPAs): Available for institutional buyers with volume commitments
🧪 Research-Exclusive Supply Chain
We do not sell to consumers. We do not support cosmetic formulation. Our systems, labeling, disclaimers, and compliance protocols are optimized EXCLUSIVELY for the laboratory research community. 🔬🇺🇸
| Service | Our Commitment |
|---|---|
| 24/7 Support | Live scientist availability via email/support portal |
| Product Replacement | Issued within 24 hours for verified transit damage or analytical non-conformance |
| Authenticity Guarantee | Full refund or replacement; no fine print |
| Technical Consultation | Protocol guidance, solubility optimization, experimental design, oxidation control strategies |
| Complaint Handling | Direct line to Quality Assurance; resolution within 24 business hours |
| Free Samples | Available for qualified institutions (≤25 mg; inquire with PI email) |
📚 Referenced Citations & Scientific Background
The following peer-reviewed and technical literature supports the research applications and specifications described above. All CAS numbers, molecular weights, and sequences have been verified against primary sources (PubChem, peer-reviewed journals, and manufacturer technical data sheets).
-
NovoPro Bioscience. (2025). SNAP-8 peptide (300001): Product Technical Data Sheet. NovoPro Laboratories.
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BenchChem. (2025). SNAP-8 (Acetyl Glutamyl Heptapeptide-3) (868844-74-0): Mechanism of Action and Biological Activity. BenchChem Technical Data.
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Habcan Life Sciences. (2014). Snap-8, Acetyl Octapeptide-3 (868844-74-0): Product Specification Sheet. Bio-Equip China.
-
BOC Sciences. (2025). SNAP-8 (CAS 868844-74-0): Product Data Sheet and LC-MS/MS Methodology. BOC Sciences.
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Ji, M., Lee, H. S., Kim, Y., et al. (2020). Method development for acetyl octapeptide-3 analysis by liquid chromatography-tandem mass spectrometry. Journal of Analytical Science and Technology, 11, 1-7.
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Lubrizol. (2023). SNAP-8™ peptide solution C: Technical Datasheet. SpecialChem Cosmetics.
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Canada Peptide. (2025). SNAP-8: A Sustainable and Non-Invasive Alternative in Anti-Wrinkle Cosmeceuticals. Canada Peptide Technical Review.
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PMC/NIH. (2025). Table 2: Botox-like Peptide Mechanisms of Action. International Journal of Molecular Sciences, 26(11), 5722.
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BioSpectrum Asia. (2026). SNAP-8: A Next-Generation Peptide Fragment in Molecular Communication Research. BioSpectrum.
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Bloom Tech. (2025). Recommendations From Old Customers–Peptides: SNAP-8, GHK-Cu, and MOTS-c. Shaanxi BLOOM Tech Co., Ltd.
⚖️ Legal Compliance & Regulatory Information
FOR LABORATORY RESEARCH USE ONLY.
NOT FOR HUMAN OR VETERINARY USE.
NOT FOR COSMETIC USE (IN VIVO).
NOT FOR FOOD OR DRUG USE.
United States Compliance:
This product is sold in strict compliance with the Federal Food, Drug, and Cosmetic Act (FD&C Act), 21 U.S.C. § 301 et seq. It is explicitly labeled for "Research Use Only" and is not intended for introduction into food, drugs, or cosmetics intended for consumer use. By purchasing this product, the buyer certifies that they are a qualified scientific professional or are acting under the direct supervision of a qualified professional in a laboratory setting.
Cosmetic Ingredient Status:
SNAP-8 is approved for use in cosmetic products in the United States, European Union, and Asian markets when manufactured to appropriate specifications . This safety determination does not constitute approval for human use or over-the-counter sale of research-grade material. Our product is research-grade, not cosmetic-grade.
DEA Compliance:
SNAP-8 is not a controlled substance under the Controlled Substances Act (21 U.S.C. § 801 et seq.). It has no known abuse liability.
Export Compliance:
Buyer is responsible for compliance with all applicable export control laws and regulations, including the International Traffic in Arms Regulations (ITAR) and Export Administration Regulations (EAR) .
California Prop 65: This product may contain chemicals known to the State of California to cause cancer and/or reproductive toxicity. Handle with appropriate PPE.
⭐ Customer Testimonials (Verified Researchers)
"We spent six months using a peptide labeled 'Argireline' for our SNARE complex reconstitution assays, wondering why our inhibition curves were so shallow. Switching to SNAP-8 from Buy Peptides Online USA gave us the expected 30% increase in competitive inhibition. The COA confirmed correct mass (1075.16 Da), no methionine oxidation, and >99% purity. Our data is finally publication-ready."
— Dr. Elena M., Principal Investigator, Neurochemistry Lab, Stanford University 🏆"The technical support team walked me through the critical distinction between hexapeptide and octapeptide sequences. Most vendors don't even know the difference. The MS spectra confirmed the correct C-terminal amidation—essential for our membrane penetration studies. Will absolutely re-order."
— Dr. James W., Research Scientist, Molecular Pharmacology, UCSD 🧪✅"We are developing LC-MS/MS methods for peptide quantification in complex formulations. The reference standard from Buy Peptides Online USA provided clean MRM transitions and excellent chromatographic resolution on our BetaBasic-18 column. The accompanying documentation included the exact LC conditions from the Ji et al. 2020 paper. Exceptional attention to detail."
— Dr. Anita V., Analytical Chemistry, University of Chicago 🔬"Fast shipping, well-packaged on dry ice, and the peptide dissolved instantly in water as specified. The amino acid analysis confirmed correct 2:1:1:2:1:1 stoichiometry. This is basic science rigor that many peptide vendors ignore."
— Michael R., PhD Candidate, Neuroscience, Harvard University 📊
🛒 How to Buy SNAP-8 Peptide Online USA
Step 1: VERIFY CAS NUMBER: You require SNAP-8 (Acetyl Octapeptide-3, CAS 868844-74-0, MW 1075.16) for SNARE complex inhibition, neuromuscular junction, and vesicle fusion research. This is distinct from Argireline (CAS 616204-22-9).
Step 2: Select your quantity from the dropdown (100 mg, 250 mg, 500 mg, or 1 g). Bulk quantities (5g, 10g, 25g, 50g, 100g+) available via inquiry.
Step 3: Specify salt form:
- ✅ TFA salt (standard; >98% purity; preferred for biochemical assays)
- ✅ Acetate salt (cell culture grade; reduced cytotoxicity; available upon request)
Step 4: Click ADD TO CART.
Step 5: Checkout securely via Stripe (credit card) or select cryptocurrency for instant discount.
Step 6: Receive order confirmation with tracking number within 1 hour.
Step 7: Download your lot-specific COA from your account dashboard immediately upon shipment.
Bulk/Wholesale Orders (≥5 grams):
- Custom synthesis available for GMP-grade material (non-GMP research grade standard)
- Multi-gram pricing discounts available
- Standing purchase agreements (SPAs) for institutional buyers
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🔬 Summary: Why This Molecule Matters
SNAP-8 represents a landmark achievement in biomimetic peptide engineering:
| Generation | Peptide | Length | Relative Efficacy | Innovation |
|---|---|---|---|---|
| 1st | Argireline® (Acetyl Hexapeptide-3) | 6 aa | Baseline (100%) | Proof-of-concept: SNAP-25 fragment inhibits SNARE |
| 2nd | SNAP-8 (Acetyl Octapeptide-3) | 8 aa | ≈130% | Elongation strategy enhances competitive inhibition |
| Future | Engineered analogs | ? | ? | AI-designed; enhanced stability; targeted delivery |
The Innovation:
By extending the SNAP-25 mimetic domain by two amino acids (Ala-Asp) , medicinal chemists:
- ✅ Increased molecular recognition by Syntaxin/VAMP
- ✅ Enhanced competitive displacement of native SNAP-25
- ✅ Achieved 30% greater efficacy without increased cytotoxicity
- ✅ Maintained aqueous solubility and ease of formulation
This is rational drug design—applied to research biochemistry.
When you purchase SNAP-8 from Buy Peptides Online USA, you are not buying a "cosmetic ingredient." You are acquiring a precisely characterized chemical tool for investigating SNARE complex dynamics, vesicle fusion mechanisms, and neuromuscular communication.
We supply the reagent. You drive the discovery. 🧠🔬⚡
⚠️ FINAL VERIFICATION WARNING:
SNAP-8 (Acetyl Octapeptide-3; CAS 868844-74-0; MW 1075.16; Sequence Ac-EEMQRRAD-NH₂) is NOT the same as:
| Incorrect Identity | CAS | MW | Why Different |
|---|---|---|---|
| Argireline® (Acetyl Hexapeptide-3) | 616204-22-9 | ~889 Da | Shorter sequence; reduced efficacy |
| Acetyl Hexapeptide-8 | 616204-22-9 | ~889 Da | Synonym for Argireline; NOT SNAP-8 |
| Leuphasyl (Pentapeptide-18) | 64963-01-5 | 569.65 Da | Opioid receptor agonist; different mechanism |
| Vialox (Pentapeptide-3) | ~135679-88-8 | ~500 Da | nAChR antagonist; different mechanism |
| Syn-Ake | 823202-99-9 | ~500 Da | Waglerin-1 mimic; different mechanism |
| Pal-GHK | 147732-56-7 | 578.8 Da | Copper-binding matrix peptide; unrelated |
These sequences, CAS numbers, molecular weights, and mechanisms are NOT interchangeable.
Verify CAS 868844-74-0 on your Certificate of Analysis immediately upon receipt.
Buy Peptides Online USA is not responsible for experimental failure due to sequence/CAS misidentification.
| Analysis Certificate |
COA Available |
|---|---|
| Certifications |
Third-Party Tested ,GMP Manufactured |
| Intended Use |
Not for Diagnostic Use ,Research Use Only (RUO) ,For Laboratory Use ,Not for Human Consumption |
| Purity |
≥98% |
| Shelf Life |
12 months |
| Storage |
Store in a Cool, Dry Place ,Protect from Light ,Refrigerate (2-8°C) |
| Form |
Topical (Cream/Gels/Drops/Patch) |
| Primary Function |
Skincare ,Anti-Aging & Longevity |
| Functional Sub-Type |
Cosmetic Peptide |
| Quantity |
200mg |