SLU-PP-332 Peptide

⚡ Introduction: Pioneering ERRγ Pathway Research with a Novel Agonist

At Buy Peptides Online USA, we proudly introduce SLU-PP-332—a groundbreaking, first-in-class peptide agonist specifically targeting the estrogen-related receptor gamma (ERRγ) for advanced metabolic and endurance research. Discovered through innovative research at Saint Louis University, this novel compound represents a significant advancement in tools available for studying mitochondrial biogenesis, energy metabolism, and exercise adaptation pathways.

Our research-grade SLU-PP-332 is synthesized to exceptional purity standards (≥98%) with comprehensive third-party analytical verification, ensuring the reliability and reproducibility required for meaningful scientific investigation. As one of the first selective pharmacological tools for modulating ERRγ activity, this peptide offers researchers unprecedented opportunities to explore this nuclear receptor’s role in cellular energy regulation, metabolic flexibility, and physical performance in experimental models.

The ERRγ Research Frontier 🧭

Estrogen-related receptor gamma (ERRγ) is an orphan nuclear receptor that functions as a key transcriptional regulator of genes involved in mitochondrial function and energy metabolism. Unlike its better-studied counterparts ERRα and ERRβ, ERRγ has remained relatively under-explored due to the historical lack of selective pharmacological tools—a gap that SLU-PP-332 now helps to fill.

🧬 What Is SLU-PP-332? Understanding This First-in-Class ERRγ Agonist

SLU-PP-332 is a novel synthetic peptide specifically designed as a potent and selective agonist of estrogen-related receptor gamma (ERRγ). This 7-amino acid peptide was developed through rational design approaches to interact with the ERRγ ligand-binding domain, representing one of the first pharmacological tools for selectively modulating this nuclear receptor’s activity in research settings.

Key Characteristics: 📊

• Peptide length: 7 amino acids
• Primary target: Estrogen-related receptor gamma (ERRγ)
• Selectivity profile: Highly selective for ERRγ over ERRα and ERRβ
• Research significance: First selective pharmacological tool for ERRγ studies

Comparative Receptor Pharmacology: ⚖️

Research Context Importance: The development of SLU-PP-332 addresses a significant pharmacological gap in nuclear receptor research, providing scientists with their first opportunity to selectively activate ERRγ and study its specific contributions to metabolic and endurance pathways separate from the other ERR isoforms.

📋 Complete Peptide Specifications & Quality Verification

Peptide Specifications Table 📋

Certificate of Analysis (COA) – Comprehensive Quality Documentation 📑

Each batch of our SLU-PP-332 includes a detailed Certificate of Analysis (COA) documenting:

• Reverse-phase HPLC analysis showing ≥98% purity with chromatogram
• Electrospray ionization mass spectrometry (ESI-MS) confirming exact molecular weight
• Amino acid analysis (AAA) verifying sequence composition
• Peptide content determination by quantitative methods
• Water content analysis (typically <3% for lyophilized peptide)
• Sterility testing (for cellular application preparations)
• Endotoxin testing (<0.1 EU/mg for sensitive cellular studies)
• pH determination of reconstituted solution
• Appearance and description confirming physical characteristics

Research Transparency: We provide batch-specific COA documentation to qualified researchers, ensuring complete analytical transparency for this novel research peptide.

🔬 Scientific Research & Potential Applications

Primary Research Mechanisms 🧪

1. ERRγ Receptor Pharmacology:

• Receptor binding: Direct interaction with ERRγ ligand-binding domain
• Transcriptional activation: Enhancement of ERRγ-mediated gene expression
• Coactivator recruitment: Promotion of transcriptional complex formation
• Selectivity mechanism: Specific molecular interactions distinguishing ERRγ from ERRα/β

2. Metabolic Pathway Research:

Mitochondrial Biogenesis Studies:

• PGC-1α interactions: ERRγ as downstream effector of PGC-1α signaling
• Oxidative phosphorylation genes: Regulation of electron transport chain components
• Fatty acid oxidation: Enhancement of mitochondrial β-oxidation capacity
• TCA cycle enzymes: Modulation of mitochondrial metabolic pathways

Exercise Physiology & Performance Research:

• Skeletal muscle adaptation: Role in exercise-induced mitochondrial biogenesis
• Endurance capacity: Potential effects on fatigue resistance and performance
• Metabolic flexibility: Switching between fuel sources during activity
• Recovery processes: Post-exercise mitochondrial remodeling

3. Tissue-Specific Research Applications: 🔬

Current Research Landscape 📚

While SLU-PP-332 is a relatively recent research development, it enters a field with substantial foundational knowledge:

• ERRγ biology: Known roles in mitochondrial function and energy metabolism
• Related pathways: Well-characterized PGC-1α/ERR signaling networks
• Disease connections: Associations with metabolic disorders, heart failure, neurodegeneration
• Therapeutic potential: Growing interest in metabolic pathway modulation

Important Research Considerations: ⚠️

• Novel compound: Limited existing literature compared to established metabolic agents
• Optimal dosing: May require empirical determination across different model systems
• Mechanistic studies: Opportunity for detailed pathway elucidation
• Comparative research: Value in comparing with other metabolic pathway modulators

✅ Why Choose Our Research-Grade SLU-PP-332?

Uncompromising Quality Standards 🏆

Pharmaceutical-Grade Peptide Synthesis:

• ≥98% purity verified by analytical HPLC
• Full structural characterization by mass spectrometry
• Sequence verification through amino acid analysis
• Batch-to-batch consistency for reproducible research

Research-Specific Advantages:

• First-in-class tool: Unique opportunity for pioneering ERRγ research
• Mechanistic specificity: Selective ERRγ targeting distinct from pan-ERR activators
• Novel insights: Potential for significant contributions to metabolic research
• Technical support: Knowledgeable assistance for ERRγ research design

Service Excellence:

• Fast USA shipping – Most orders processed within 24-48 hours
• Complete documentation – Batch-specific COA with all analytical data
• Research compliance – Strict adherence to laboratory-use guidelines
• Discreet packaging – Professional, research-appropriate presentation

Comparative Research Value ⚖️

🌡️ Handling, Storage & Laboratory Protocols

Optimal Storage Conditions ❄️

• Lyophilized powder: -20°C in airtight, light-resistant container
• Long-term storage: -80°C for extended preservation (years)
• Reconstituted solution: Aliquot and store at -20°C or -80°C
• Critical protection: Minimize freeze-thaw cycles to preserve activity
• Moisture control: Store with desiccant to prevent hydrolysis

Reconstitution & Handling Guidelines 💧

1. Solvent selection: Sterile water or appropriate buffer for experimental system
2. Concentration preparation: Stock solutions typically 1-10 mM
3. Aliquoting strategy: Single-use aliquots to avoid degradation
4. Sterility maintenance: Aseptic technique for cellular applications
5. Stability monitoring: Document storage duration and conditions

Research Protocol Considerations 🐭

When designing studies with SLU-PP-332:

• Dose optimization: Essential for novel compounds—wide range initially recommended
• Positive controls: Consider other metabolic pathway activators for comparison
• Time course studies: Account for transcriptional vs. non-transcriptional effects
• Endpoint selection: Include mitochondrial, metabolic, and functional measures
• Model validation: Confirm ERRγ expression in chosen experimental system

❓ Frequently Asked Questions (FAQS)

Q: What makes SLU-PP-332 unique among metabolic research compounds?

A: SLU-PP-332 is the first selective pharmacological agonist of ERRγ, a nuclear receptor specifically involved in mitochondrial biogenesis and oxidative metabolism. This selectivity allows researchers to study ERRγ-specific effects separately from the related ERRα and ERRβ receptors for the first time.

Q: How does ERRγ differ from the more commonly studied ERRα?

A: While both are involved in metabolic regulation, ERRγ shows more restricted tissue expression (particularly high in heart, skeletal muscle, and brain) and may regulate distinct gene subsets related to oxidative metabolism. ERRγ also has different coactivator requirements and potentially different physiological roles.

Q: What experimental endpoints are most relevant for SLU-PP-332 studies?

A: Key endpoints include mitochondrial biogenesis markers (mitochondrial DNA, respiratory chain proteins), metabolic gene expression (PCR arrays for metabolic pathways), cellular respiration (Seahorse assays), metabolite profiling, and in exercise models, endurance performance measures.

Q: What cell lines or animal models express sufficient ERRγ for studies?

A: Skeletal muscle cells (C2C12, primary myocytes), cardiomyocytes, hepatocytes, and certain neuronal cells typically express significant ERRγ. In animal models, skeletal muscle, heart, and brain tissues show the highest expression levels for tissue-specific studies.

Q: How should SLU-PP-332 be reconstituted and stored?

A: Reconstitute with sterile water or appropriate buffer, prepare single-use aliquots at desired concentrations, store lyophilized powder at -20°C, and keep reconstituted aliquots at -20°C or below. Avoid repeated freeze-thaw cycles and document all handling procedures.

Q: What control compounds are recommended for comparison studies?

A: General metabolic activators (AICAR, GW501516), mitochondrial biogenesis inducers (exercise models, PGC-1α overexpression), and vehicle controls provide useful comparisons. For receptor specificity studies, ERRα-selective compounds (if available) or ERRγ knockdown/knockout models offer mechanistic insights.

⚠️ Critical Compliance & Safety Information

Intended Use Statement 📋

SLU-PP-332 Peptide is sold exclusively for laboratory research applications by qualified personnel in controlled settings. These products are:

• NOT for human or veterinary use
• NOT for consumption
• NOT intended as drugs, cosmetics, or dietary supplements
• NOT for diagnostic or therapeutic applications

Research Ethics & Design Considerations: ⚠️

• Novel compound validation: Appropriate controls and replication essential
• Mechanistic studies: Should include receptor specificity confirmation where possible
• Dose-response characterization: Important for establishing compound pharmacology
• Comparative analysis: Against known metabolic modulators for context

Regulatory Compliance: ⚖️

Researchers accept full responsibility for ensuring:

• All research complies with institutional guidelines and applicable regulations
• Materials are used only in approved laboratory facilities
• Documentation is maintained for all research purposes
• Safety protocols are followed for peptide handling

🚀 Ordering & Research Support

Streamlined Research Procurement 📦

1. Select Quantity – Based on research scope and experimental design
2. Secure Checkout – Multiple payment options available
3. Fast Processing – Most orders ship within 1-2 business days
4. Complete Documentation – Batch-specific COA provided

Technical Support 🔬

• Research design consultation available
• Analytical documentation for all batches
• Storage and handling guidance provided
• Compliance information for research applications

💎 Research Significance of Selective ERRγ Targeting

For investigators exploring mitochondrial biology, exercise metabolism, or nuclear receptor pharmacology, SLU-PP-332 offers a unique and valuable research tool. As the first selective ERRγ agonist available to researchers, it enables previously impossible investigations into this receptor’s specific contributions to metabolic regulation and endurance adaptation.

With high purity, complete analytical characterization, and research-grade quality, SLU-PP-332 provides a reliable tool for pioneering studies that could significantly advance our understanding of metabolic regulation and potentially identify new approaches to metabolic disorders.

For laboratory research use only. Not for human consumption.