Sermorelin Peptide

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The Foundational GHRH Analog: An Introduction to Sermorelin Peptide 🔬

For researchers focused on the fundamental architecture of the Growth Hormone (GH) axis, Sermorelin represents the original and benchmark synthetic analog of Growth Hormone-Releasing Hormone (GHRH). This 29-amino acid peptide corresponds to the bioactive core fragment of the endogenous 44-amino acid human GHRH, retaining its full biological activity while providing a more focused tool for investigating the primary control mechanism of GH synthesis and release .

Sermorelin’s significance in research lies in its specificity and direct mechanism of action. Unlike growth hormone secretagogues (GHSs) that act through the ghrelin receptor (GHS-R1a), Sermorelin specifically binds to and activates the GHRH receptor on pituitary somatotroph cells. This makes it an indispensable tool for isolating and studying the GHRH signaling pathway without the confounding variables introduced by other endocrine axes.

What is Sermorelin Peptide?

Sermorelin is the synthetic acetate salt of GHRH(1-29)-NH₂, consisting of the first 29 amino acids of the N-terminal sequence of human GHRH . Its full sequence is Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂ . Upon binding to the GHRH receptor, it activates the stimulatory G-protein (Gs), which in turn activates adenylyl cyclase. This leads to an increase in intracellular cyclic AMP (cAMP), activation of protein kinase A (PKA), and subsequent transcription and release of growth hormone . Its molecular formula is C₁₄₉H₂₄₆N₄₄O₄₂S with a molecular weight of approximately 3357.9 g/mol.

🔬 Primary Research Focuses and Applications

The Sermorelin Peptide is a cornerstone tool in endocrine research, utilized to investigate a broad spectrum of physiological questions:

• GHRH Receptor Pharmacology and Signaling: As the specific agonist for the GHRH receptor, Sermorelin is the primary tool for studying receptor-ligand binding kinetics, receptor density, and the downstream signaling cascades (cAMP/PKA) that lead to GH synthesis. It is essential for research into receptor desensitization and the regulatory feedback loops controlling GHRH sensitivity .
• Pulsatile GH Release and Axis Restoration: Sermorelin is the classic agent for modeling the body’s natural, episodic GH release patterns. Its short half-life makes it ideal for studying the physiological significance of GH pulse amplitude and frequency, and for investigating how the somatotropic axis responds to exogenous GHRH stimulation .
• Comparative Studies with GHSs and Other GHRH Analogs: Researchers use Sermorelin as a baseline to compare the effects of other GHRH analogs (like CJC-1295 or modified GRF 1-29) and growth hormone secretagogues (like GHRP-2, GHRP-6, or Ipamorelin). This allows for the dissection of the distinct contributions of GHRH-R versus GHS-R1a activation to overall GH output .
• Aging and Somatopause Research: GH secretion naturally declines with age, a phenomenon known as somatopause. Sermorelin is frequently used in research models to study the age-related decline in pituitary responsiveness and to explore potential interventions to restore GH pulsatility .
• Metabolic and Body Composition Studies: By stimulating endogenous GH release, Sermorelin is relevant for research into the downstream effects of GH on lipid metabolism (lipolysis), protein synthesis, and overall energy homeostasis, helping to clarify the role of the GH-IGF-1 axis in these processes .

🧪 Product Specifications & Technical Data

At Buy Peptides Online USA, we ensure your research is built on a foundation of quality and consistency. This peptide is manufactured to rigorous laboratory standards and verified through advanced analytical methods.

✅ Why Choose Buy Peptides Online USA for Your Research?

Sourcing reliable research compounds is critical for reproducible, high-impact science. Here is why researchers across the USA trust us:

• Verified Purity & Potency: We provide access to Certificates of Analysis (COA) and rely on advanced analytical methods like High Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to confirm the molecular weight and purity (>99%) of every batch . This commitment ensures the integrity of your experimental data.
• Research-Focused Integrity: We strictly adhere to research-use-only (RUO) guidelines. Our product descriptions are factual, focusing on chemical properties and cited research applications, never unverified human-use claims.
• Fast & Discreet USA Shipping: We offer fast, reliable shipping across the United States with discreet packaging to ensure your order arrives safely, professionally, and on time for your critical research timelines. Enjoy free shipping on orders over $300.
• Expert Support & Authenticity Guarantee: Our team provides technical consultation to support your work. We stand behind the authenticity and quality of all our products, offering a product replacement service and clear complaint handling.

📝 Handling, Storage, & Important Safety Information

• Handling & Reconstitution: This product is for laboratory use only by qualified professionals. Use proper aseptic technique. Reconstitute by injecting the diluent (e.g., bacteriostatic water) slowly against the inner wall of the vial to prevent foaming. Swirl gently—do not shake, as this can damage the peptide structure. Note that peptides are typically supplied as acetate salts from the synthesis process, which generally enhances solubility in aqueous solutions .
• Safety: Always wear appropriate personal protective equipment (PPE), including lab coats, gloves, and safety glasses. Dispose of any sharps and biological waste according to your institutional guidelines.
• Stability Considerations: Lyophilized peptides are stable when stored desiccated at -20°C or below . Once reconstituted, peptides are significantly less stable. Sermorelin should be refrigerated at 2-8°C and used within 30 days. Avoid repeated freeze-thaw cycles at all costs, as these can lead to peptide degradation and reduced bioactivity .
• Warning: This product is not for human or veterinary use. It is not a drug, food, or cosmetic. Do not ingest or inject.

❓ Frequently Asked Questions (FAQs)

Q: What is the primary research advantage of using Sermorelin over other GHRH analogs?

A: Sermorelin is the original, benchmark GHRH analog . While newer analogs like modified GRF (1-29) or CJC-1295 are engineered for extended half-life, Sermorelin’s shorter half-life makes it the preferred tool for studying pulsatile GH release and the natural dynamics of GHRH-receptor interaction without prolonged receptor occupancy .

Q: How does Sermorelin differ from Growth Hormone Secretagogues (GHSs) like GHRP-2 or Ipamorelin?

A: They act through completely different receptors. Sermorelin binds specifically to the GHRH receptor, activating the cAMP/PKA pathway to stimulate GH synthesis and release. GHSs bind to the ghrelin receptor (GHS-R1a) and primarily act through calcium-mediated pathways. Their effects on GH release are synergistic, and Sermorelin is often used in research alongside GHSs to study this synergy .

Q: What is the significance of the C-terminal amidation in Sermorelin?

A: The peptide is synthesized as an amidated form (…-Ser-Arg-NH₂). This C-terminal amidation is crucial for biological activity and stability, as it protects the peptide from rapid degradation by carboxypeptidases and mimics the naturally occurring amidated form of endogenous GHRH .

Q: How do you verify the purity and identity of Sermorelin?

A: We ensure every batch is rigorously analyzed using High Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) . HPLC confirms a purity level of ≥99% by separating the peptide from any related impurities (e.g., truncated sequences, oxidation products). Mass Spectrometry is critical for confirming the identity by measuring the precise molecular weight (~3575 g/mol for the acetate salt), ensuring the correct peptide sequence and post-synthetic modifications.

Q: What are the critical storage conditions for this lyophilized peptide, especially once mixed?

A: Store the lyophilized powder at -20°C (-4°F) . Once reconstituted with bacteriostatic water, store it in the refrigerator at 2-8°C and use within 30 days . Always avoid repeated freeze-thaw cycles, as this will degrade the peptide and render it inactive.

Q: Is Sermorelin prohibited in sports research?

A: Yes, researchers should be aware that Sermorelin, as a growth hormone-releasing hormone (GHRH) and its analogs, is classified as a peptide hormone and is included on the World Anti-Doping Agency (WADA) Prohibited List. It is intended for legitimate scientific research only.

Ready to Advance Your Research? 🚀

Equip your laboratory with the foundational research tool for studying the GH axis. Order high-purity Sermorelin Peptide today from Buy Peptides Online USA. Benefit from our fast USA shipping, secure payments (including crypto), and the confidence that comes from rigorously tested research compounds. For any questions about this product or your order, our support team is here to provide technical consultation.