Sermorelin, Ipamorelin (Blend)

Welcome to Buy Peptides Online USA, your premier source for high-purity research compounds designed for serious laboratory investigations. This product is intended strictly for in vitro and in vivo laboratory research use only and is not for human or veterinary consumption.

The Gold Standard for Selective GH Axis Research: An Introduction to Sermorelin and Ipamorelin 🔬

For researchers focused on modeling the most natural and refined aspects of the Growth Hormone (GH) axis, the Sermorelin, Ipamorelin (Blend) is widely regarded as a “gold standard” research tool. This pre-formulated combination unites the foundational, benchmark synthetic analog of Growth Hormone-Releasing Hormone (GHRH) with the most highly selective member of the growth hormone secretagogue (GHS) family. Together, they allow for the exploration of theorized synergistic effects through distinct, yet complementary, intracellular pathways while minimizing confounding variables associated with less selective compounds .

Instead of sourcing and dosing these peptides separately, this blend provides a consistent ratio, reducing variables in your experimental protocols. This dual-action approach allows for a nuanced examination of how GHRH receptor stimulation and selective GHS-R1a activation integrate to influence GH pulsatility, second-messenger systems, and downstream effector molecules like IGF-1, offering the cleanest possible model for studying the body’s natural GH release dynamics .

What is Sermorelin and Ipamorelin?

• Sermorelin: This peptide is the synthetic acetate salt of GHRH(1-29)-NH₂, consisting of the first 29 amino acids of the N-terminal sequence of human GHRH . Its full sequence is Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂. Sermorelin specifically binds to and activates the GHRH receptor on pituitary somatotroph cells. This activates the stimulatory G-protein (Gs), which in turn activates adenylyl cyclase, leading to an increase in intracellular cyclic AMP (cAMP) and subsequent GH synthesis and release. It is the foundational GHRH analog used for studying the primary control mechanism of GH .
• Ipamorelin: A synthetic pentapeptide and highly selective agonist of the growth hormone secretagogue receptor (GHS-R1a) , also known as the ghrelin receptor. Its sequence is Aib-His-D-2-Nal-D-Phe-Lys-NH₂. Often described as a “selective GHS,” Ipamorelin is distinguished by its focused mechanism of action. Research suggests it stimulates GH release with minimal effect on other hormones like cortisol, prolactin, or ACTH, making it a precise tool for studying targeted GH secretion pathways without broad endocrine disruption . Its molecular formula is C₃₈H₄₉N₉O₅ with a molecular weight of approximately 711.9 g/mol.

🔬 Primary Research Focuses and Applications

The Sermorelin & Ipamorelin Blend is primarily utilized in scientific research to investigate a broad spectrum of physiological and pharmacological questions:

• Physiological Pulsatile GH Release and Axis Restoration: This blend is the premier tool for “pulsatile restoration” research . By combining a short-acting GHRH analog with a highly selective GHS that doesn’t disrupt other pituitary hormones, researchers can model the body’s natural, episodic release of GH. This is essential for studying endocrine feedback loops, circadian rhythms, and the physiological significance of GH pulse amplitude and frequency in the cleanest possible system .
• Dual-Pathway GPCR Signaling and Selective Synergy: Studying how a highly selective GHS-R1a agonist (Ipamorelin) and a GHRH-R agonist (Sermorelin) work together to amplify GH pulses. This allows for the investigation of signal integration, second-messenger kinetics (such as cAMP/PKA pathways), and receptor cross-talk without the confounding activation of other hormonal axes .
• Metabolic Regulation and Body Composition: Exploring the role of enhanced GH-IGF-1 signaling in lipid metabolism (lipolysis), protein synthesis, and the regulation of energy balance. The selective nature of Ipamorelin makes this blend particularly useful for isolating the metabolic effects of GH from other stress-related hormonal changes (cortisol) or lactogenic effects (prolactin) .
• Recovery, Repair, and Cellular Regeneration: Investigating the anabolic signals that contribute to tissue recovery, muscle protein synthesis, and joint function following stress or injury models, using a tool that mimics natural physiology as closely as possible .
• Comparative Pharmacology and Receptor Selectivity Studies: Utilizing Ipamorelin’s high selectivity as a benchmark to compare against other GHSs (like GHRP-2, GHRP-6, or Hexarelin) in studies mapping receptor-ligand interactions, functional selectivity, and downstream signaling cascades. This blend provides the baseline for understanding what “pure” GHS-R1a agonism looks like in conjunction with GHRH stimulation .

🧪 Product Specifications & Technical Data

At Buy Peptides Online USA, we ensure your research is built on a foundation of quality and consistency. This blend is manufactured to rigorous laboratory standards and verified through advanced analytical methods .

✅ Why Choose Buy Peptides Online USA for Your Research?

Sourcing reliable research compounds is critical for reproducible, high-impact science. Here is why researchers across the USA trust us:

• Verified Purity & Potency: We provide access to Certificates of Analysis (COA) and rely on advanced analytical methods like High Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to confirm the molecular weight and purity (>99%) of every batch. This commitment ensures the integrity of your experimental data.
• Research-Focused Integrity: We strictly adhere to research-use-only (RUO) guidelines. Our product descriptions are factual, focusing on chemical properties and cited research applications, never unverified human-use claims .
• Fast & Discreet USA Shipping: We offer fast, reliable shipping across the United States with discreet packaging to ensure your order arrives safely, professionally, and on time for your critical research timelines. Enjoy free shipping on orders over $300.
• Expert Support & Authenticity Guarantee: Our team provides technical consultation to support your work. We stand behind the authenticity and quality of all our products, offering a product replacement service and clear complaint handling.

📝 Handling, Storage, & Important Safety Information

• Critical Storage Information – Lyophilized State: All of our peptides are manufactured using the Lyophilization (Freeze Drying) process, which ensures that they remain stable for shipping for extended periods. The lyophilized powder can be stored at room temperature temporarily, but for long-term storage (several months to years), it is optimal to store peptides in a freezer at -20°C or below .
• Handling & Reconstitution: This product is for laboratory use only by qualified professionals. Use proper aseptic technique. Reconstitute by injecting the diluent (e.g., bacteriostatic water) slowly against the inner wall of the vial to prevent foaming. Swirl gently—do not shake, as this can damage the peptide structure.
• Storage After Reconstitution: Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge at 2-8°C to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days .
• Safety: Always wear appropriate personal protective equipment (PPE), including lab coats, gloves, and safety glasses. Dispose of any sharps and biological waste according to your institutional guidelines.
• Warning: This product is not for human or veterinary use. It is not a drug, food, or cosmetic. Do not ingest or inject .

❓ Frequently Asked Questions (FAQs)

Q: What is the primary research advantage of blending Sermorelin with Ipamorelin?

A: This blend is considered the “gold standard” for modeling physiological GH release . It combines the cAMP-driven, pulsatile GHRH stimulation of Sermorelin with the highly selective GHS-R1a-mediated GH release of Ipamorelin, which has minimal effect on other pituitary hormones like cortisol, prolactin, or ACTH . This allows researchers to study a refined model of GH axis regulation with the fewest confounding variables.

Q: What makes Ipamorelin “selective” compared to other GHRPs?

A: Ipamorelin is characterized as a “selective GHS” because research suggests it stimulates GH release with minimal effect on other pituitary hormones such as adrenocorticotropic hormone (ACTH), prolactin, or cortisol . This focused receptor profile makes it a valuable tool for studying GH-specific pathways without the broader endocrine activation seen with compounds like GHRP-6 .

Q: How does Sermorelin differ from other GHRH analogs like Mod GRF?

A: Sermorelin is the original, benchmark GHRH(1-29) analog . While newer analogs like Mod GRF (CJC-1295 no DAC) are engineered for extended half-life, Sermorelin’s shorter half-life makes it a classic tool for studying natural, pulsatile dynamics. This blend leverages the well-understood, foundational properties of Sermorelin with the selectivity of Ipamorelin.

Q: How do you verify the purity of the blend?

A: We ensure every batch is rigorously analyzed using High Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) . HPLC confirms a purity level of ≥99% for each component, while Mass Spectrometry verifies the precise molecular weight of both Sermorelin (~3357.9 g/mol) and Ipamorelin (~711.9 g/mol), ensuring the correct peptide structure and identity.

Q: What are the critical storage conditions for this lyophilized peptide?

A: For optimal long-term stability, store the lyophilized powder at -20°C (-4°F) or below, protected from light and moisture . Once reconstituted with bacteriostatic water, it is critical to store it in the refrigerator at 2-8°C and use it within 30 days . Always avoid repeated freeze-thaw cycles, as this will degrade the peptides and render them inactive.

Q: Is this peptide blend prohibited in sports research?

A: Yes, researchers should be aware that both Sermorelin and Ipamorelin are classified as peptide hormones, releasing factors, and secretagogues, and are included on the World Anti-Doping Agency (WADA) Prohibited List. They are intended for legitimate scientific research only.

Ready to Advance Your Research? 🚀

Equip your laboratory with the gold-standard research tool for selective GH axis studies. Order the high-purity Sermorelin, Ipamorelin (Blend) today from Buy Peptides Online USA. Benefit from our fast USA shipping, secure payments (including crypto), and the confidence that comes from rigorously tested research compounds. For any questions about this product or your order, our support team is here to provide technical consultation.