P-21 Peptide (P021)

P-21 Peptide (P021, CNTF-Derived Peptide)

Welcome to buypeptidesonlineusa.com, your premier domestic source for high-purity research peptides. Our P-21 Peptide (P021) is a small, synthetic tetra-peptide designed as a mimetic of ciliary neurotrophic factor (CNTF). It is meticulously manufactured for advanced investigations into neurogenesis, cognitive enhancement, Alzheimer's disease (AD) pathology, and neurodegenerative disorders. As a blood-brain barrier (BBB) permeable compound with a favorable pharmacological profile, P-21 is an essential tool for researchers exploring neurotrophic support, synaptic plasticity, and disease-modifying interventions in the central nervous system (CNS). We ensure your critical research is supported by uncompromising quality, transparency, and rapid fulfillment.

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⚠️ Important Research Compliance Notice

This product is intended strictly for laboratory research use only and is not for human consumption or veterinary use. This product is not a medicine, drug, or medical device. It has not been evaluated by the FDA. This peptide is sold for investigational purposes by qualified researchers and professionals only.

🔬 What is P-21 Peptide (P021)?

P-21 (also known as P021) is a small synthetic tetra-peptide derived from the most active region of ciliary neurotrophic factor (CNTF), specifically amino acid residues 148-151 . It is a cyclin-dependent kinase (CDK) inhibitor-1 and is also known by its chemical structure, Ac-DGGLAG-NH2 . The peptide includes an adamantylated glycine at the C-terminal end, a crucial modification that enhances its ability to cross the blood-brain barrier (BBB) and reduces degradation by exopeptidases .

Native CNTF is a naturally occurring protein that promotes neuron development, neurotransmitter synthesis, and neurite outgrowth, and protects neurons from inflammatory assaults . However, its therapeutic use is hindered because it is too large to cross the BBB, has poor plasma stability, and can promote the development of anti-CNTF antibodies . P-21 was developed using epitope mapping to overcome these limitations, creating a small molecule that mimics CNTF's beneficial effects while being BBB-permeable, stable in plasma, and free from the side effects of the whole protein .

Its key mechanisms of action in research include:

• BDNF Upregulation: P-21 significantly increases levels of brain-derived neurotrophic factor (BDNF) by increasing its transcription, likely through the inhibition of leukemia inhibitory factor (LIF) signaling and activation of the CREB pathway . BDNF is crucial for neuronal survival, synaptic plasticity, and neurogenesis.
• Neurogenesis Promotion: Studies show P-21 enhances neurogenesis, particularly in the dentate gyrus of the hippocampus, a region vital for learning and memory. It increases cell proliferation and the maturation of newly born neurons .
• Reduction of Alzheimer's Pathologies: P-21 has been shown to robustly attenuate tau pathology and mildly reduce amyloid-β (Aβ) pathologies in animal models of AD. This effect is probably mediated via the BDNF/TrkB/PI3-K/AKT/GSK3β pathway .
• Inhibition of GSK3β Activity: By decreasing the activity of glycogen synthase kinase-3 beta (GSK3β), a key enzyme involved in tau hyperphosphorylation, P-21 helps prevent the formation of neurofibrillary tangles .

✅ Why Choose Buy Peptides Online USA for Your Research?

When you need to buy P-21 peptide online, quality and consistency are non-negotiable. Here is why discerning researchers choose us:

• Verified High Purity: We provide access to independent third-party Certificate of Analysis (COA) documents, confirming purity via High-Performance Liquid Chromatography (HPLC) at ≥99% and identity via Mass Spectrometry (MS) .
• Authentic Structure: Our peptide is the synthetic, acetylated, and amidated form (Ac-DGGLAG-NH2) with the correct molecular weight, matching the compound validated in pre-clinical studies .
• Optimal Storage & Handling: Our P-21 is shipped in lyophilized (freeze-dried) powder form. For long-term stability, store desiccated at -20°C or below . In lyophilized form, it is stable for up to 24 months .
• Domestic Shipping: As a USA-based supplier, we offer fast, reliable shipping. Orders typically arrive within 2-5 business days in discreet, temperature-controlled packaging.
• Research-Focused: We make no medical claims. Our service is built on integrity, providing accurately labeled products for legitimate scientific inquiry.

🔎 Product Specifications & Technical Data

To ensure your research parameters are met with precision, here are the verified technical specifications for our P-21 peptide. Purity and correct structure are critical determinants of research accuracy, and our product meets the high standards expected by the scientific community .

🧪 Key Research Applications & Focus Areas

P-21's unique neurotrophic and neurogenic properties make it a powerful and precise tool across a wide spectrum of neuroscience research .

• 🧠 Alzheimer's Disease (AD) & Neurodegeneration Research: This is a primary and extensively studied application of P-21. In animal models (including 3xTg-AD mice), P-21 has been shown to have a disease-modifying effect. It robustly attenuates tau pathology and mildly reduces amyloid-β (Aβ) pathologies. It rescues deficits in neurogenesis, neuronal plasticity, and cognition, positioning it as a potential disease-modifying treatment for AD . Research suggests its effects are mediated via the BDNF/TrkB/PI3-K/AKT/GSK3β pathway .

• 🧬 Neurogenesis & Synaptic Plasticity Research: P-21 is a key tool for studying the enhancement of neurogenesis. Studies in normal adult mice show that peripheral administration of P-21 enhances learning, short-term and spatial reference memories. This is accompanied by induced enhancement of neurogenesis and maturation of newly born neurons in the granular cell layer and subgranular zone of the dentate gyrus . It also increases markers of synaptic plasticity like GluR1, Synapsin 1, and NR1 .

• 🔄 Down Syndrome (DS) & Developmental Delay Research: P-21 has shown significant promise in models of Down syndrome. In the Ts65Dn mouse model of DS, prenatal to early postnatal treatment with P-21 rescued developmental delay in pups and AD-like hippocampus-dependent memory impairments in adult life. This treatment prevented pre-synaptic protein deficits and increased levels of synaptic plasticity markers including BDNF and phosphorylated CREB .

• 🛡️ Cognitive Enhancement & Memory Research: Beyond disease models, P-21 is studied for its general nootropic potential. By increasing BDNF and promoting neurogenesis, it has been shown to improve learning and memory in normal, healthy animals . This makes it a valuable probe for understanding the fundamental biology of memory formation and cognitive function.

📝 Handling, Storage, and Preparation for Research

Proper handling is critical to maintaining P-21's integrity and ensuring experimental validity .

• Receiving & Storage: Upon receipt, store the lyophilized vial in a freezer at -20°C (-4°F) or below . Protect from light and moisture. Lyophilized peptide is stable for up to 24 months under these conditions .
• Reconstitution: To prepare stock solutions, allow the vial to reach room temperature in a desiccator. P-21 is soluble in sterile water and bacteriostatic water . Gently swirl or invert to dissolve; do not vortex.
• Aliquoting & Storage Post-Reconstitution: It is highly recommended to prepare single-use aliquots immediately after reconstitution to avoid repeated freeze-thaw cycles .
  • For short-term use, store aliquots at 2-8°C.
  • For long-term storage, store aliquots at -20°C or below.
• Dosage Considerations (for reference):
  • In vivo (Rodent): Preclinical studies have used various routes and dosages. For example, in early postnatal treatment, P-021 was administered to mothers/dams in the diet (200 nmoles/g diet) . General research dosages reported are 100-500 mcg daily (SubQ) for 4-6 weeks, or 500 mcg-1mg daily (intranasal) , sometimes increased to 2-4mg for acute effects . Researchers must determine optimal dosing based on literature and IACUC guidelines.
• Safety & Handling: Always use personal protective equipment (PPE) such as gloves and safety goggles when handling. Work in a laminar flow hood or well-ventilated area. Dispose of all waste in appropriate biohazard containers.

❓ Frequently Asked Questions (FAQ)

Q1: What is the difference between P-21 and full-length CNTF?

A: P-21 is a small synthetic tetra-peptide that mimics the most active region of CNTF. Unlike native CNTF, P-21 is designed to be blood-brain barrier (BBB) permeable, has superior plasma stability, and does not promote the development of anti-CNTF antibodies, making it a more favorable tool for research .

Q2: How does P-21 exert its effects on Alzheimer's-related pathologies?

A: P-21 increases levels of brain-derived neurotrophic factor (BDNF) . BDNF, in turn, activates pathways that reduce the activity of GSK3β, an enzyme responsible for tau hyperphosphorylation. This cascade helps clear tau protein build-up and reduces the production of amyloid-β plaques .

Q3: How do I verify the quality of your P-21 peptide?

A: We are committed to transparency. Our product listings provide access to a third-party Certificate of Analysis (COA) . This document validates the compound's identity via Mass Spectrometry (MS) and its purity via High-Performance Liquid Chromatography (HPLC), which is ≥99% .

Q4: What are the primary research areas for P-21?

A: It is primarily used in Alzheimer's disease (AD) research, neurogenesis and synaptic plasticity studies, Down syndrome (DS) models, and general cognitive enhancement research .

Q5: What is the correct way to store P-21 after reconstitution?

A: It is essential to aliquot the reconstituted solution into single-use vials to avoid repeated freeze-thaw cycles. Store aliquots at -20°C or below. For short-term use (a few days), it can be stored at 2-8°C .

📦 Our Services & Guarantees

• 24/7 Customer Support: Our team is available to answer your pre- and post-sales questions.
• Authenticity Guarantee: We guarantee that you receive the exact product described, with full documentation and lot matching.
• Product Replacement: In the unlikely event of damage during shipping, we have a clear process for claims and replacement.
• Technical Consultation: Contact us for assistance with solubility or handling protocols.

🚀 How to Buy P-21 Peptide Online

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1. Browse & Select: Choose the quantity you need (e.g., 5mg, 10mg vial).
2. Add to Cart: Proceed to our secure checkout.
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4. Shipping: Orders are processed within 24 hours on business days and shipped in discreet, temperature-controlled packaging. Domestic orders typically arrive in 2-5 days.

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