MOTS-c Peptide

MOTS-c Peptide (Mitochondrial ORF of the 12S rRNA-c)

Welcome to buypeptidesonlineusa.com, your premier domestic source for high-purity research peptides. Our MOTS-c peptide is a synthetic 16-amino acid mitochondrial-derived peptide (MDP), identical to the endogenous signaling molecule encoded within the mitochondrial 12S rRNA. It is meticulously manufactured for advanced investigations into metabolic regulation, insulin sensitivity, aging biology, mitochondrial function, and exercise physiology. As a key mediator of cellular retrograde signaling, MOTS-c is an essential tool for researchers exploring the frontiers of metabolic health and longevity. We ensure your critical research is supported by uncompromising quality, transparency, and rapid fulfillment.

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⚠️ Important Research Compliance Notice

This product is intended strictly for laboratory research use only and is not for human consumption or veterinary use. This product is not a medicine, drug, or medical device. It has not been evaluated by the FDA. This peptide is sold for investigational purposes by qualified researchers and professionals only.

🔬 What is MOTS-c Peptide?

MOTS-c (Mitochondrial ORF of the 12S rRNA-c) is a 16-amino acid peptide encoded by a short open reading frame (sORF) within the mitochondrial 12S rRNA gene . It belongs to a growing family of mitochondrial-derived peptides (MDPs) that act as signaling molecules, communicating the energetic state of the mitochondria to the rest of the cell and the body—a process known as mitochondrial retrograde signaling .

Discovered relatively recently, MOTS-c has emerged as a crucial regulator of metabolic homeostasis, with its primary target organ being skeletal muscle . Its expression is responsive to energy states and factors like exercise . The peptide can even translocate to the nucleus during metabolic stress to regulate the expression of nuclear genes involved in adaptation and cellular balance .

The primary mechanisms of MOTS-c's action are:

• AMPK Activation: MOTS-c inhibits the folate cycle and its tethered de novo purine biosynthesis pathway, leading to the accumulation of the endogenous AMP analog AICAR. This, in turn, activates AMP-activated protein kinase (AMPK) , a master regulator of cellular energy homeostasis .
• Insulin Sensitization: By activating AMPK in skeletal muscle, MOTS-c promotes glucose uptake and fatty acid oxidation, thereby enhancing insulin sensitivity and improving metabolic profiles .
• AKT Pathway Modulation: Research has confirmed that MOTS-c can also modulate the AKT signaling pathway, another key regulator of metabolism and cell survival .
• Nuclear Gene Regulation: Under conditions of metabolic stress, MOTS-c can enter the nucleus and interact with chromatin to regulate the expression of genes involved in adaptation, stress response, and metabolism .

✅ Why Choose Buy Peptides Online USA for Your Research?

When you need to buy MOTS-c peptide online, quality and consistency are non-negotiable. Here is why discerning researchers choose us:

• Verified Purity: We provide access to independent third-party Certificate of Analysis (COA) documents, confirming purity via High-Performance Liquid Chromatography (HPLC) exceeding 98% and identity via Mass Spectrometry (MS) .
• Optimal Storage & Handling: Our MOTS-c is shipped in lyophilized form. For long-term stability, store desiccated at -20°C or below, protected from light and moisture . Although stable at room temperature for up to 3 weeks, long-term storage requires freezing .
• Domestic Shipping: As a USA-based supplier, we offer fast, reliable shipping. Orders typically arrive within 2-5 business days in discreet, temperature-controlled packaging.
• Research-Focused: We make no medical claims. Our service is built on integrity, providing accurately labeled products for legitimate scientific inquiry.
• Secure Transactions: Enjoy peace of mind with secure checkout and multiple payment options, including credit cards and cryptocurrency.

🔎 Product Specifications & Technical Data

To ensure your research parameters are met with precision, here are the verified technical specifications for our MOTS-c peptide. Purity is a critical determinant of research accuracy, and our product meets the high standards expected by the scientific community.

🧪 Key Research Applications & Focus Areas

MOTS-c's central role in mitochondrial signaling makes it a powerful and versatile tool across a wide spectrum of biomedical research .

• 🩺 Metabolic & Diabetes Research (Type 2 Diabetes): This is a primary application of MOTS-c. It is extensively used to study its effects on insulin sensitivity, glucose metabolism, and energy homeostasis . A 2025 PubMed review highlights its key role in regulating metabolic homeostasis, with insufficient MOTS-c production contributing to the pathological development of type 2 diabetes mellitus (T2DM) and its complications, including diabetic cardiomyopathy . Researchers use it to model interventions for metabolic syndrome and obesity .

• 🕰️ Aging & Longevity Research: Circulating MOTS-c levels are known to decline with age in humans, and this decline is associated with increased risk of age-related diseases such as insulin resistance, sarcopenia, and frailty . MOTS-c is a critical tool for studying the biology of aging and the role of mitochondrial dysfunction in the aging process. It has been shown to extend lifespan in animal models and is investigated for its potential to promote healthy aging and healthspan .

• 💪 Muscle Biology & Sarcopenia Research: As its primary target is skeletal muscle, MOTS-c is fundamental for studying muscle metabolism, adaptation to exercise, and age-related muscle loss (sarcopenia) . It enhances muscle fiber regeneration, improves mitochondrial function in aged muscle, and correlates with better muscle function and strength in older adults . It is also an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline .

• ❤️ Cardiovascular Research: Beyond its metabolic effects, MOTS-c shows promise in cardiovascular research. It has been shown to attenuate vascular calcification and secondary myocardial remodeling via the AMPK signaling pathway . Its protective potential in diabetic cardiomyopathy is a specific focus of recent research .

• 🧬 Cellular Stress & Inflammation: MOTS-c helps buffer the intracellular environment against oxidative damage and supports cellular adaptation during metabolic stress . It is also being explored for its anti-inflammatory and immune-regulatory functions .

📝 Handling, Storage, and Preparation for Research

Proper handling is critical to maintaining peptide integrity and ensuring experimental validity .

• Receiving & Storage: Upon receipt, store the lyophilized vial in a freezer at -20°C (-4°F) or below. Protect from light and moisture. Lyophilized MOTS-c is stable for up to 3 years under these conditions .
• Reconstitution: To prepare stock solutions, briefly centrifuge the vial to concentrate the powder. MOTS-c is soluble in sterile 18MΩ-cm H₂O at a concentration of at least 100 µg/ml . Gently swirl or invert to dissolve; do not vortex.
• Dosage Considerations:
  • In vitro: Studies often use concentrations in the low micromolar (µM) range to observe effects on AMPK activation and gene expression .
  • In vivo (Rodent): Preclinical studies in mouse models have used various doses and schedules to prevent age-dependent and high-fat diet-induced insulin resistance . Researchers must determine optimal dosing based on literature and IACUC guidelines.
• Preventing Adsorption: At low concentrations, peptides can adsorb to plastic surfaces. To prevent this, use low-protein-binding tubes and consider adding a carrier protein (e.g., 0.1% BSA) to the dilution buffer .
• Safety & Handling: Always use personal protective equipment (PPE) such as gloves and safety goggles when handling. Work in a laminar flow hood or well-ventilated area. Dispose of all waste in appropriate biohazard containers.

❓ Frequently Asked Questions (FAQ)

Q1: What makes MOTS-c unique among other peptides?

A: MOTS-c is unique because it is a mitochondrial-derived peptide (MDP) , meaning it is encoded by mitochondrial DNA rather than nuclear DNA. It acts as a signaling molecule in mitochondrial retrograde signaling, communicating the organelle's status to the rest of the cell to regulate metabolism, stress responses, and gene expression .

Q2: What is the primary mechanism of MOTS-c?

A: MOTS-c's primary mechanism involves inhibiting the folate cycle to increase levels of AICAR, which in turn activates AMP-activated protein kinase (AMPK) , a master regulator of cellular energy balance . It can also translocate to the nucleus to regulate gene expression .

Q3: How do I verify the quality of your MOTS-c?

A: We are committed to transparency. Our product listings provide access to a third-party Certificate of Analysis (COA) . This document validates the compound's identity via Mass Spectrometry (MS) and its purity via High-Performance Liquid Chromatography (HPLC), which is ≥98% .

Q4: What are the primary research areas for MOTS-c?

A: It is primarily used in metabolic disease (type 2 diabetes, obesity) , aging and longevity, muscle biology (sarcopenia) , and cardiovascular research .

Q5: What is the correct way to store MOTS-c after reconstitution?

A: For short-term use (2-7 days), store the solution at 4°C. For longer storage, it is essential to aliquot the solution into single-use vials and freeze at -20°C or below. Adding a carrier protein like 0.1% BSA is highly recommended to maintain stability. Avoid repeated freeze-thaw cycles .

📦 Our Services & Guarantees

• 24/7 Customer Support: Our team is available to answer your pre- and post-sales questions.
• Authenticity Guarantee: We guarantee that you receive the exact product described, with full documentation and lot matching.
• Product Replacement: In the unlikely event of damage during shipping, we have a clear process for claims and replacement.
• Technical Consultation: Contact us for assistance with solubility or handling protocols.

🚀 How to Buy MOTS-c Peptide Online

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1. Browse & Select: Choose the quantity you need (e.g., 500 µg, 1mg, 5mg vial).
2. Add to Cart: Proceed to our secure checkout.
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4. Shipping: Orders are processed within 24 hours on business days and shipped in discreet, temperature-controlled packaging. Domestic orders typically arrive in 2-5 days.

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