Mod GRF, Ipamorelin, GHRP-2 (Blend)

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Unlocking Complete Synergy: The Mod GRF, Ipamorelin & GHRP-2 Peptide Blend 🔬

For researchers seeking the most comprehensive tool to investigate the Growth Hormone (GH) axis, the Mod GRF (CJC-1295 no DAC), Ipamorelin & GHRP-2 (Blend) represents the ultimate pre-formulated combination. This tri-peptide blend unites a modified, enzymatically stable growth hormone-releasing hormone (GHRH) analog with two distinct growth hormone secretagogues (GHSs)—one prized for its high selectivity and the other for its potent cAMP-potentiating effects. Together, they allow for the exploration of theorized maximal synergistic effects through three distinct, yet complementary, intracellular pathways, providing the most complete model for studying somatotropic signaling .

Instead of sourcing and dosing these peptides separately, this blend provides a consistent ratio, reducing variables in your experimental protocols. This triple-action approach allows for a nuanced examination of how GHRH receptor stimulation and dual GHS-R1a activation (via both selective and potent agonists) integrate to influence GH pulsatility, second-messenger systems, and downstream effector molecules like IGF-1 .

What are the components of this blend?

• Mod GRF (1-29): Often referred to as CJC-1295 without DAC or Modified GRF (1-29) , this peptide is a synthetic analog of the first 29 amino acids of endogenous human GHRH . Specific amino acid substitutions have been engineered to increase its resistance to enzymatic degradation, thereby extending its bioactive half-life in research models . Its primary mechanism involves binding to the GHRH receptor on pituitary somatotroph cells, which activates adenylate cyclase, leading to an increase in intracellular cyclic AMP (cAMP) and subsequent GH synthesis and release .
• Ipamorelin: A synthetic pentapeptide and highly selective agonist of the growth hormone secretagogue receptor (GHS-R1a) . Often described as a “selective GHS,” Ipamorelin is distinguished by its focused mechanism of action. Research suggests it stimulates GH release with minimal effect on other hormones like cortisol, prolactin, or ACTH, making it a precise tool for studying targeted GH secretion pathways without broad endocrine disruption . Its molecular formula is C₃₈H₄₉N₉O₅ with a molecular weight of approximately 711.9 g/mol.
• GHRP-2 (Growth Hormone Releasing Peptide-2): A synthetic hexapeptide and potent, full agonist of the growth hormone secretagogue receptor (GHS-R1a) . Upon binding to GHS-R1a, it primarily activates Gq/11-protein-mediated signaling, leading to phospholipase C activation and the mobilization of intracellular calcium. Notably, GHRP-2 is also known to potentiate cAMP accumulation, making it a powerful amplifier of the cAMP signal generated by Mod GRF . Its molecular formula is C₄₅H₅₅N₉O₆ with a molecular weight of approximately 817.98 g/mol.

🔬 Primary Research Focuses and Applications

The Mod GRF, Ipamorelin & GHRP-2 Blend is primarily utilized in scientific research to investigate:

• Maximal Synergistic GH Pulse Amplification and Signal Integration: This blend is the premier tool for achieving maximal GH pulse stimulation in research models. It allows for the study of how a cAMP-driven GHRH analog (Mod GRF) synergizes with two different GHS-R1a agonists—one that potentiates cAMP (GHRP-2) and one that is highly selective (Ipamorelin)—to produce a coordinated and amplified response .
• Comparative GHS-R1a Pharmacology and Selectivity Studies: This blend provides an internal control for studying receptor pharmacology. Researchers can use the presence of both a highly selective agonist (Ipamorelin) and a potent, broad-spectrum agonist (GHRP-2) within the same model to map receptor-ligand binding affinities, functional selectivity, and downstream signaling cascades .
• Pulsatile GH Release and Axis Restoration: By combining a short-acting GHRH analog with two distinct GHSs, researchers can model a highly refined version of the body’s natural, episodic release of GH, studying the physiological significance of GH pulse amplitude and frequency .
• Metabolic Regulation and Body Composition: Exploring the role of enhanced GH-IGF-1 signaling in lipid metabolism (lipolysis), protein synthesis, and the regulation of energy balance, using a tool that stimulates multiple nodes of the GH axis .
• Recovery, Repair, and Cellular Regeneration: Investigating the anabolic signals that contribute to tissue recovery, muscle protein synthesis, and joint function following stress or injury models, leveraging the full potential of the GH axis .

🧪 Product Specifications & Technical Data

At Buy Peptides Online USA, we ensure your research is built on a foundation of quality and consistency. This blend is manufactured to rigorous laboratory standards and verified through advanced analytical methods.

✅ Why Choose Buy Peptides Online USA for Your Research?

Sourcing reliable research compounds is critical for reproducible, high-impact science. Here is why researchers across the USA trust us:

• Verified Purity & Potency: We provide access to Certificates of Analysis (COA) and rely on advanced analytical methods like High Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to confirm the molecular weight and purity (>99%) of every batch . This commitment ensures the integrity of your experimental data.
• Research-Focused Integrity: We strictly adhere to research-use-only (RUO) guidelines. Our product descriptions are factual, focusing on chemical properties and cited research applications, never unverified human-use claims.
• Fast & Discreet USA Shipping: We offer fast, reliable shipping across the United States with discreet packaging to ensure your order arrives safely, professionally, and on time for your critical research timelines. Enjoy free shipping on orders over $300.
• Expert Support & Authenticity Guarantee: Our team provides technical consultation to support your work. We stand behind the authenticity and quality of all our products, offering a product replacement service and clear complaint handling.

📝 Handling, Storage, & Important Safety Information

• Handling & Reconstitution: This product is for laboratory use only by qualified professionals. Use proper aseptic technique. Reconstitute by injecting the diluent (e.g., bacteriostatic water) slowly against the inner wall of the vial to prevent foaming. Swirl gently—do not shake, as this can damage the peptide structure .
• Safety: Always wear appropriate personal protective equipment (PPE), including lab coats, gloves, and safety glasses. Dispose of any sharps and biological waste according to your institutional guidelines.
• Stability Considerations: Lyophilized peptides are stable when stored desiccated at -20°C or below . Once reconstituted, peptides are significantly less stable. Of the three components, Mod GRF is the least stable in solution, making prompt use within 30 days essential to minimize its degradation . Avoid repeated freeze-thaw cycles at all costs, as these can lead to peptide degradation and reduced bioactivity for all components.
• Warning: This product is not for human or veterinary use. It is not a drug, food, or cosmetic. Do not ingest or inject .

❓ Frequently Asked Questions (FAQs)

Q: What is the primary research advantage of this triple blend over a dual blend?

A: This blend provides the most comprehensive tool for studying the GH axis. It combines the cAMP-driven, pulsatile GHRH stimulation of Mod GRF with two different GHS-R1a agonists: the highly selective Ipamorelin and the potent, cAMP-potentiating GHRP-2. This allows researchers to study maximal synergistic GH release, comparative receptor pharmacology, and the integration of multiple signaling pathways within a single experimental model .

Q: What makes GHRP-2 different from Ipamorelin in this blend?

A: While both are GHS-R1a agonists, they have distinct pharmacological profiles. Ipamorelin is highly selective, stimulating GH release with minimal effect on other hormones like cortisol or prolactin . GHRP-2 is a more potent GH releaser and is also known to potentiate cAMP accumulation, which synergizes powerfully with the cAMP signal generated by Mod GRF . Their combination allows for a nuanced study of signal integration.

Q: What is the difference between CJC-1295 with DAC and without DAC (Mod GRF)?

A: The presence of DAC (Drug Affinity Complex) significantly extends the peptide’s half-life (to about 8 days), leading to a continuous, non-physiological elevation of GH levels. Mod GRF (CJC-1295 no DAC) has a much shorter half-life and is theorized to stimulate GH release in a more natural, pulsatile fashion, which is essential for studies aiming to mimic endogenous secretion patterns .

Q: How do you verify the purity of such a complex blend?

A: We ensure every batch is rigorously analyzed using High Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) . HPLC confirms a purity level of ≥99% for each individual component, while Mass Spectrometry verifies the precise molecular weight of all three peptides—Mod GRF (~3367.9 g/mol), Ipamorelin (~711.9 g/mol), and GHRP-2 (~817.98 g/mol)—ensuring the correct structure and identity of each.

Q: What are the critical storage conditions for this lyophilized peptide, especially once mixed?

A: Store the lyophilized powder at -20°C (-4°F) . Once reconstituted with bacteriostatic water, store it in the refrigerator at 2-8°C. It is critical to use the reconstituted blend within 30 days to minimize degradation, particularly of the Mod GRF component . Always avoid repeated freeze-thaw cycles, as this will degrade all peptides.

Q: Is this peptide blend prohibited in sports research?

A: Yes, researchers should be aware that all three components—Ipamorelin, GHRP-2, and modified GRF 1-29—are classified as peptide hormones, releasing factors, and secretagogues, and are included on the World Anti-Doping Agency (WADA) Prohibited List . They are intended for legitimate scientific research only.

Ready to Advance Your Research? 🚀

Equip your laboratory with the most comprehensive research tool. Order the high-purity Mod GRF, Ipamorelin, GHRP-2 (Blend) today from Buy Peptides Online USA. Benefit from our fast USA shipping, secure payments (including crypto), and the confidence that comes from rigorously tested research compounds. For any questions about this product or your order, our support team is here to provide technical consultation.