Mod GRF, Ipamorelin (Blend)

Welcome to Buy Peptides Online USA, your premier source for high-purity research compounds designed for serious laboratory investigations. This product is intended strictly for in vitro and in vivo laboratory research use only and is not for human or veterinary consumption.

Unlocking Physiological Synergy: The Mod GRF and Ipamorelin Peptide Blend 🔬

For researchers focused on modeling the most natural and refined aspects of the Growth Hormone (GH) axis, the Mod GRF (CJC-1295 no DAC), Ipamorelin (Blend) is widely regarded as the “gold standard” research tool. This pre-formulated combination unites a modified, enzymatically stable growth hormone-releasing hormone (GHRH) analog with the most highly selective member of the growth hormone secretagogue (GHS) family. Together, they allow for the exploration of theorized synergistic effects through distinct, yet complementary, intracellular pathways while minimizing confounding variables associated with less selective compounds .

Instead of sourcing and dosing these peptides separately, this blend provides a consistent ratio, reducing variables in your experimental protocols. This dual-action approach allows for a nuanced examination of how GHRH receptor stimulation and selective GHS-R1a activation integrate to influence GH pulsatility, second-messenger systems, and downstream effector molecules like IGF-1, offering the cleanest possible model for studying the body’s natural GH release patterns .

What is Mod GRF (CJC-1295 no DAC) and Ipamorelin?

• Mod GRF (1-29): Often referred to as CJC-1295 without DAC or Modified GRF (1-29) , this peptide is a synthetic analog of the first 29 amino acids of endogenous human GHRH . Specific amino acid substitutions (e.g., replacing an L-amino acid with a D-amino acid) have been engineered to increase its resistance to enzymatic degradation by dipeptidyl peptidase-4 (DPP-4), thereby extending its bioactive half-life in research models compared to native GHRH(1-29) . Its primary mechanism involves binding to the GHRH receptor on pituitary somatotroph cells, which activates adenylate cyclase, leading to an increase in intracellular cyclic AMP (cAMP) and subsequent GH synthesis and release .
• Ipamorelin: A synthetic pentapeptide and highly selective agonist of the growth hormone secretagogue receptor (GHS-R1a) , also known as the ghrelin receptor. Often described as a “selective GHS,” Ipamorelin is distinguished by its focused mechanism of action. Research suggests it stimulates GH release with minimal effect on other hormones like cortisol, prolactin, or ACTH, making it a precise tool for studying targeted GH secretion pathways without broad endocrine disruption . Its molecular formula is C₃₈H₄₉N₉O₅ with a molecular weight of approximately 711.9 g/mol .

🔬 Primary Research Focuses and Applications

The Mod GRF & Ipamorelin Blend is primarily utilized in scientific research to investigate:

• Physiological Pulsatile GH Release and Axis Restoration: This blend is the premier tool for “pulsatile restoration” research . By combining a short-acting GHRH analog with a highly selective GHS that doesn’t disrupt other pituitary hormones, researchers can model the body’s natural, episodic release of GH. This is essential for studying endocrine feedback loops, circadian rhythms, and the physiological significance of GH pulse amplitude and frequency in the cleanest possible system .
• Dual-Pathway GPCR Signaling and Selective Synergy: Studying how a highly selective GHS-R1a agonist (Ipamorelin) and a GHRH-R agonist (Mod GRF) work together to amplify GH pulses. This allows for the investigation of signal integration, second-messenger kinetics (such as cAMP/PKA pathways), and receptor cross-talk without the confounding activation of other hormonal axes .
• Metabolic Regulation and Body Composition: Exploring the role of enhanced GH-IGF-1 signaling in lipid metabolism (lipolysis), protein synthesis, and the regulation of energy balance. The selective nature of Ipamorelin makes this blend particularly useful for isolating the metabolic effects of GH from other stress-related hormonal changes (cortisol) or lactogenic effects (prolactin) .
• Recovery, Repair, and Cellular Regeneration: Investigating the anabolic signals that contribute to tissue recovery, muscle protein synthesis, and joint function following stress or injury models, using a tool that mimics natural physiology as closely as possible .
• Comparative Pharmacology and Receptor Selectivity Studies: Utilizing Ipamorelin’s high selectivity as a benchmark to compare against other GHSs (like GHRP-2, GHRP-6, or Hexarelin) in studies mapping receptor-ligand interactions, functional selectivity, and downstream signaling cascades. This blend provides the baseline for understanding what “pure” GHS-R1a agonism looks like in conjunction with GHRH stimulation .

🧪 Product Specifications & Technical Data

At Buy Peptides Online USA, we ensure your research is built on a foundation of quality and consistency. This blend is manufactured to rigorous laboratory standards and verified through advanced analytical methods.

✅ Why Choose Buy Peptides Online USA for Your Research?

Sourcing reliable research compounds is critical for reproducible, high-impact science. Here is why researchers across the USA trust us:

• Verified Purity & Potency: We provide access to Certificates of Analysis (COA) and rely on advanced analytical methods like High Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to confirm the molecular weight and purity (>99%) of every batch . This commitment ensures the integrity of your experimental data.
• Research-Focused Integrity: We strictly adhere to research-use-only (RUO) guidelines. Our product descriptions are factual, focusing on chemical properties and cited research applications, never unverified human-use claims.
• Fast & Discreet USA Shipping: We offer fast, reliable shipping across the United States with discreet packaging to ensure your order arrives safely, professionally, and on time for your critical research timelines. Enjoy free shipping on orders over $300.
• Expert Support & Authenticity Guarantee: Our team provides technical consultation to support your work. We stand behind the authenticity and quality of all our products, offering a product replacement service and clear complaint handling.

📝 Handling, Storage, & Important Safety Information

• Handling & Reconstitution: This product is for laboratory use only by qualified professionals. Use proper aseptic technique. Reconstitute by injecting the diluent (e.g., bacteriostatic water) slowly against the inner wall of the vial to prevent foaming. Swirl gently—do not shake, as this can damage the peptide structure .
• Safety: Always wear appropriate personal protective equipment (PPE), including lab coats, gloves, and safety glasses. Dispose of any sharps and biological waste according to your institutional guidelines.
• Stability Considerations: Lyophilized peptides are stable when stored desiccated at -20°C or below . Once reconstituted, peptides are significantly less stable and should be refrigerated and used promptly. While Ipamorelin is relatively stable, Mod GRF is less stable in solution, making prompt use within 30 days essential . Avoid repeated freeze-thaw cycles at all costs, as these can lead to peptide degradation and reduced bioactivity .
• Warning: This product is not for human or veterinary use. It is not a drug, food, or cosmetic. Do not ingest or inject .

❓ Frequently Asked Questions (FAQs)

Q: What is the primary research advantage of blending Mod GRF with Ipamorelin?

A: This blend is considered the “gold standard” for modeling physiological GH release . It combines the cAMP-driven, pulsatile GHRH stimulation of Mod GRF with the highly selective GHS-R1a-mediated GH release of Ipamorelin, which has minimal effect on other pituitary hormones like cortisol, prolactin, or ACTH . This allows researchers to study a refined model of GH axis regulation with the fewest confounding variables.

Q: What makes Ipamorelin “selective” compared to other GHRPs?

A: Ipamorelin is characterized as a “selective GHS” because research suggests it stimulates GH release with minimal effect on other pituitary hormones such as adrenocorticotropic hormone (ACTH), prolactin, or cortisol . This focused receptor profile makes it a valuable tool for studying GH-specific pathways without the broader endocrine activation seen with compounds like GHRP-6 .

Q: What is the difference between CJC-1295 with DAC and without DAC (Mod GRF)?

A: The presence of DAC (Drug Affinity Complex) significantly extends the peptide’s half-life (to about 8 days), leading to a continuous, non-physiological elevation of GH levels. Mod GRF (CJC-1295 no DAC) has a much shorter half-life (around 30 minutes) and is theorized to stimulate GH release in a more natural, pulsatile fashion, which is essential for studies aiming to mimic endogenous secretion patterns and avoid potential receptor desensitization .

Q: How do you verify the purity of the blend?

A: We ensure every batch is rigorously analyzed using High Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) . HPLC confirms a purity level of ≥99% for each component, while Mass Spectrometry verifies the precise molecular weight of both Mod GRF (~3367.9 g/mol) and Ipamorelin (~711.9 g/mol), ensuring the correct peptide structure and identity .

Q: What are the critical storage conditions for this lyophilized peptide, especially once mixed?

A: Store the lyophilized powder at -20°C (-4°F) . Once reconstituted with bacteriostatic water, store it in the refrigerator at 2-8°C. It is important to use the reconstituted blend within 30 days to minimize degradation of the Mod GRF component . Always avoid repeated freeze-thaw cycles.

Q: Is this peptide blend prohibited in sports research?

A: Yes, researchers should be aware that both Ipamorelin and modified GRF 1-29 are classified as peptide hormones, releasing factors, and secretagogues, and are included on the World Anti-Doping Agency (WADA) Prohibited List . They are subject to detection in doping control analyses and are intended for legitimate scientific research only.

Ready to Advance Your Research? 🚀

Equip your laboratory with the gold-standard research tool. Order the high-purity Mod GRF (CJC-1295 no DAC), Ipamorelin (Blend) today from Buy Peptides Online USA. Benefit from our fast USA shipping, secure payments (including crypto), and the confidence that comes from rigorously tested research compounds. For any questions about this product or your order, our support team is here to provide technical consultation.