Mod GRF, Hexarelin (Blend)

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Unlocking Potent Synergy: The Mod GRF and Hexarelin Peptide Blend 🔬

For researchers focused on maximizing the investigative potential of the Growth Hormone (GH) axis while exploring unique cardiometabolic pathways, the Mod GRF (CJC-1295 no DAC), Hexarelin (Blend) represents a uniquely powerful and sophisticated research tool. This pre-formulated combination unites a modified, enzymatically stable growth hormone-releasing hormone (GHRH) analog with the most stable and pluripotent member of the growth hormone secretagogue (GHS) family to explore their theorized synergistic effects through distinct, yet complementary, intracellular pathways .

Instead of sourcing and dosing these peptides separately, this blend provides a consistent ratio, reducing variables in your experimental protocols. This dual-action approach allows for a nuanced examination of how GHRH receptor stimulation and GHS-R1a activation integrate to influence GH pulsatility, second-messenger systems, downstream effector molecules like IGF-1, and unique pathways such as the cardioprotective effects associated with Hexarelin’s interaction with the CD36 receptor .

What is Mod GRF (CJC-1295 no DAC) and Hexarelin?

• Mod GRF (1-29): Often referred to as CJC-1295 without DAC or Modified GRF (1-29) , this peptide is a synthetic analog of the first 29 amino acids of endogenous human GHRH . Specific amino acid substitutions (e.g., replacing an L-amino acid with a D-amino acid) have been engineered to increase its resistance to enzymatic degradation by dipeptidyl peptidase-4 (DPP-4), thereby extending its bioactive half-life in research models compared to native GHRH(1-29) . Its primary mechanism involves binding to the GHRH receptor on pituitary somatotroph cells, which activates adenylate cyclase, leading to an increase in intracellular cyclic AMP (cAMP) and subsequent GH synthesis and release .
• Hexarelin: A synthetic hexapeptide and exceptionally stable, potent, full agonist of the growth hormone secretagogue receptor (GHS-R1a) . Its enhanced resistance to enzymatic degradation, owing to a methyl group on the tryptophan residue (D-2-methyl-Trp), results in robust and sustained activity in research models . Upon binding to GHS-R1a, it primarily activates Gq/11-protein-mediated signaling, leading to phospholipase C activation, inositol triphosphate (IP3) generation, and the mobilization of intracellular calcium—a critical trigger for GH vesicle fusion and release . Crucially, Hexarelin is distinguished by its ability to bind to CD36, a scavenger receptor expressed on cardiomyocytes, opening unique avenues for cardiovascular research beyond the classic GH axis .

🔬 Primary Research Focuses and Applications

The Mod GRF & Hexarelin Blend is primarily utilized in scientific research to investigate a broad spectrum of physiological and pharmacological questions:

• Maximal GH Pulse Amplification and Signal Integration: This blend is considered a premier tool for achieving maximal GH pulse stimulation in research models. By combining a GHRH analog (cAMP pathway) with the most stable GHS-R1a agonist (IP3/Ca²⁺ pathway), researchers can study the upper limits of somatotroph stimulation and the complex integration of these two critical signaling cascades .
• Cardiovascular Protection & Ischemia-Reperfusion Injury: A leading area of Hexarelin research involves its cardioprotective properties, mediated through binding to the CD36 receptor on cardiomyocytes and the subsequent activation of protective signaling pathways like PI3K/Akt, independently of GH release . This blend allows researchers to study these direct cardiac pathways in conjunction with systemic GH/IGF-1 signaling .
• Comparative GHS-R1a Pharmacology and Selectivity Studies: Due to its enhanced stability and potency, Hexarelin is often used in comparative studies with other GHSs like GHRP-2, GHRP-6, and Ipamorelin to map receptor-ligand binding affinities, functional selectivity, and patterns of GH pulse amplification. Notably, Hexarelin is reported to stimulate GH release with less impact on appetite compared to GHRP-6, making it valuable for dissecting orexigenic pathways .
• Metabolic Regulation and Body Composition Research: Hexarelin has been shown in studies to reduce visceral fat, making this blend relevant for research into lipid metabolism (lipolysis), protein synthesis, and the regulation of energy balance .
• Dual-Pathway GPCR Signaling and Receptor Crosstalk: Utilizing the blend to map the integration of signals from two different G-protein-coupled receptors (GPCRs)—GHS-R1a and GHRH-R—provides insights into how cells integrate multiple hormonal inputs to produce a coordinated response, including the role of IGF-1 as a downstream mediator of muscle and tissue effects .

🧪 Product Specifications & Technical Data

At Buy Peptides Online USA, we ensure your research is built on a foundation of quality and consistency. This blend is manufactured to rigorous laboratory standards and verified through advanced analytical methods.

✅ Why Choose Buy Peptides Online USA for Your Research?

Sourcing reliable research compounds is critical for reproducible, high-impact science. Here is why researchers across the USA trust us:

• Verified Purity & Potency: We provide access to Certificates of Analysis (COA) and rely on advanced analytical methods like High Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to confirm the molecular weight and purity (>99%) of every batch . This commitment ensures the integrity of your experimental data.
• Research-Focused Integrity: We strictly adhere to research-use-only (RUO) guidelines. Our product descriptions are factual, focusing on chemical properties and cited research applications, never unverified human-use claims.
• Fast & Discreet USA Shipping: We offer fast, reliable shipping across the United States with discreet packaging to ensure your order arrives safely, professionally, and on time for your critical research timelines. Enjoy free shipping on orders over $300.
• Expert Support & Authenticity Guarantee: Our team provides technical consultation to support your work. We stand behind the authenticity and quality of all our products, offering a product replacement service and clear complaint handling.

📝 Handling, Storage, & Important Safety Information

• Handling & Reconstitution: This product is for laboratory use only by qualified professionals. Use proper aseptic technique. Reconstitute by injecting the diluent (e.g., bacteriostatic water) slowly against the inner wall of the vial to prevent foaming. Swirl gently—do not shake, as this can damage the peptide structure. Note that peptides are typically supplied as trifluoroacetate (TFA) salts from the HPLC purification process, which may contribute to total peptide mass but generally enhances solubility .
• Safety: Always wear appropriate personal protective equipment (PPE), including lab coats, gloves, and safety glasses. Dispose of any sharps and biological waste according to your institutional guidelines.
• Stability Considerations: Lyophilized peptides are stable when stored desiccated at -20°C or below . Once reconstituted, peptides are significantly less stable and should be refrigerated and used promptly. Avoid repeated freeze-thaw cycles at all costs, as these can lead to peptide degradation and reduced bioactivity .
• Warning: This product is not for human or veterinary use. It is not a drug, food, or cosmetic. Do not ingest or inject.

❓ Frequently Asked Questions (FAQs)

Q: What is the primary research advantage of blending Mod GRF with Hexarelin?

A: The blend combines the cAMP-driven GHRH receptor stimulation of Mod GRF with the uniquely stable, GHS-R1a-mediated GH release and CD36-mediated cardioprotective signaling of Hexarelin . This dual-pathway activation allows researchers to study a more complete model of GH axis regulation alongside direct cardiac pathways, often achieving maximal GH pulse stimulation.

Q: What makes Hexarelin different from other GHRPs like GHRP-6?

A: Hexarelin is structurally similar to GHRP-6 but contains a methyl group on the D-tryptophan residue (D-2-methyl-Trp), making it significantly more resistant to enzymatic breakdown . This results in enhanced stability and a longer duration of action. Notably, Hexarelin stimulates GH release with less impact on appetite compared to GHRP-6, and its well-documented ability to bind to the CD36 receptor gives it a unique profile in cardiovascular research .

Q: What is the significance of the CD36 receptor in Hexarelin research?

A: CD36 is a scavenger receptor found on various cells, including cardiomyocytes (heart muscle cells) and macrophages . Research indicates that Hexarelin’s cardioprotective effects, particularly against ischemia-reperfusion injury, are mediated through its binding to CD36 and the subsequent activation of protective signaling pathways like PI3K/Akt, independently of GH release .

Q: What is the difference between CJC-1295 with DAC and without DAC (Mod GRF)?

A: The presence of DAC (Drug Affinity Complex) significantly extends the peptide’s half-life in a research model (to about 8 days), leading to a continuous, non-physiological elevation of GH levels. Mod GRF (CJC-1295 no DAC) has a much shorter half-life and is theorized to stimulate GH release in a more natural, pulsatile fashion, which is essential for studies aiming to mimic endogenous secretion patterns .

Q: How do you verify the purity of the blend?

A: We ensure every batch is rigorously analyzed using High Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) . HPLC confirms a purity level of ≥99% for each component, while Mass Spectrometry verifies the precise molecular weight of both Mod GRF (~3367.9 g/mol) and Hexarelin (~887.05 g/mol), ensuring the correct peptide structure and identity .

Q: What are the critical storage conditions for this lyophilized peptide, especially once mixed?

A: Store the lyophilized powder at -20°C (-4°F) . Once reconstituted with bacteriostatic water, store it in the refrigerator at 2-8°C and use within 30 days to minimize degradation. Always avoid repeated freeze-thaw cycles .

Q: Is Hexarelin prohibited in sports research?

A: Yes, researchers should be aware that Hexarelin is classified as a growth hormone secretagogue and is included on the World Anti-Doping Agency (WADA) Prohibited List. It is subject to detection in doping control analyses and is intended for legitimate scientific research only.

Ready to Advance Your Research? 🚀

Equip your laboratory with a trusted research tool. Order the high-purity Mod GRF (CJC-1295 no DAC), Hexarelin (Blend) today from Buy Peptides Online USA. Benefit from our fast USA shipping, secure payments (including crypto), and the confidence that comes from rigorously tested research compounds. For any questions about this product or your order, our support team is here to provide technical consultation.