MK-677 (Ibutamoren)

💊 Introduction: A Potent Oral Growth Hormone Secretagogue for Research

Welcome to Buy Peptides Online USA, your premier source for cutting-edge research compounds. We proudly present MK-677 (Ibutamoren)—a potent, orally active, long-acting growth hormone secretagogue developed for research into growth hormone (GH) and insulin-like growth factor 1 (IGF-1) pathways. Unlike injectable growth hormone-releasing peptides, MK-677 represents a significant advancement in research convenience due to its oral bioavailability and extended half-life, making it an invaluable tool for extended-duration studies of GH/IGF-1 axis modulation in preclinical models.

Our research-grade MK-677 capsules are manufactured to exacting pharmaceutical standards (≥99% purity) and undergo rigorous third-party analytical verification to ensure batch-to-batch consistency and reliability. Each capsule contains precisely measured quantities, eliminating preparation variables and ensuring accurate, reproducible dosing throughout your research timeline. Whether investigating somatotropic axis physiology, body composition mechanisms, or sleep architecture effects, our MK-677 provides the quality and documentation that serious scientific investigation demands.

Research Compound Classification Clarification 🔍

While often categorized with peptides, MK-677 (Ibutamoren) is technically a non-peptide mimetic of ghrelin—a small molecule that mimics the activity of the natural GH-releasing peptide ghrelin. This distinction is important for researchers as it confers different pharmacological properties including oral bioavailability and metabolic stability compared to peptide GH secretagogues.

🧬 What Is MK-677 (Ibutamoren)? Understanding This Ghrelin Mimetic

MK-677, also known as Ibutamoren, is a non-peptide, orally active growth hormone secretagogue that functions as a potent agonist of the ghrelin receptor (growth hormone secretagogue receptor type 1a, GHS-R1a). Chemically designated as 2-amino-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]propanamide mesylate, it represents a breakthrough in growth hormone research tools due to its oral activity and prolonged duration of action.

Key Characteristics of MK-677: 📊

• Chemical class: Spiropiperidine-based benzolactam (non-peptide)
• Mechanism: Ghrelin receptor (GHS-R1a) agonist
• Bioavailability: Orally active (60-80% in animal models)
• Half-life: Approximately 6-8 hours in preclinical models
• Specificity: Selective for GHS-R1a over other receptors

Comparison with Other GH Research Compounds: ⚖️

Important Research Distinction: Unlike direct growth hormone administration, MK-677 stimulates endogenous GH secretion through ghrelin receptor activation, maintaining the pulsatile pattern of natural GH release—a critical factor for researchers studying physiological GH regulation versus pharmacological replacement.

📋 Complete Chemical Specifications & Quality Verification

Chemical Specifications Table 📋

Certificate of Analysis (COA) – Comprehensive Quality Documentation 📑

Each batch of our MK-677 includes a detailed Certificate of Analysis (COA) documenting:

• HPLC purity analysis showing ≥99% main peak with chromatogram
• Mass spectrometry confirmation of molecular identity
• Nuclear Magnetic Resonance (NMR) spectroscopy confirming structure
• Optical rotation measurement verifying enantiomeric purity
• Ultraviolet-visible spectroscopy confirming characteristic absorption
• Loss on drying determination (<0.5%)
• Residual solvent analysis per ICH guidelines
• Heavy metal screening (Pb, Cd, Hg, As < 2 ppm each)
• Microbiological testing (total aerobic count < 100 CFU/g)
• Endotoxin testing (<0.1 EU/mg where applicable)

Research Transparency: We provide batch-specific COA documentation to qualified researchers, offering complete analytical transparency for this important research compound.

🔬 Scientific Research & Potential Applications

Primary Research Mechanisms 🧪

1. Growth Hormone Secretagogue Activity:

• GHS-R1a agonism: Potent, selective activation of ghrelin receptor
• Endogenous GH release: Stimulates pulsatile GH secretion from pituitary
• IGF-1 elevation: Increases insulin-like growth factor 1 production
• Ghrelin mimetic activity: Mimics natural hunger hormone effects

2. Research Applications by System:

Endocrine System Research:

• Somatotropic axis studies: GH/IGF-1 feedback regulation
• Pulsatile secretion patterns: Natural versus pharmacological GH release
• Receptor desensitization: GHS-R1a downregulation with prolonged activation
• Cross-talk with other axes: Interactions with HPA, HPT, and gonadal axes

Metabolic & Body Composition Research:

• Nitrogen retention studies: Protein synthesis and anticatabolic effects
• Lipid metabolism: Effects on adipose tissue and lipid profiles
• Glucose homeostasis: Insulin sensitivity and glucose tolerance
• Bone metabolism: Effects on bone density and turnover markers

Neurological & Sleep Research:

• Slow-wave sleep enhancement: Effects on sleep architecture
• Appetite regulation: Ghrelin-mediated hunger signaling
• Cognitive function: Potential GH/IGF-1 effects on cognition
• Neuroprotection: IGF-1 mediated neuronal support mechanisms

3. Dose-Dependent Research Effects: 📈

Current Research Landscape 📚

MK-677 has been investigated in various preclinical and limited clinical research contexts:

• Aging research: GH/IGF-1 decline in aging models
• Catabolic states: Muscle wasting, cachexia models
• Bone health: Osteoporosis and fracture healing studies
• Sleep research: Slow-wave sleep enhancement mechanisms
• Metabolic syndrome: Body composition and insulin sensitivity

Important Research Considerations: ⚠️

• Oral bioavailability: Approximately 60-80% in animal models
• Delayed IGF-1 response: Peak effects may take days to weeks
• Dose-dependent effects: Linear response at lower doses, plateau at higher
• Carrier proteins: Highly protein-bound in circulation
• Metabolism: Hepatic metabolism with multiple metabolites

✅ Why Choose Our Research-Grade MK-677?

Uncompromising Quality Standards 🏆

Pharmaceutical-Grade Purity:

• ≥99% purity verified by HPLC with chromatographic evidence
• Enantiomeric purity >99% ensuring optimal receptor activity
• Batch-to-batch consistency for reproducible research outcomes
• Comprehensive impurity profiling with full characterization

Research-Specific Advantages:

• Precisely encapsulated – Eliminates weighing errors
• Optimized formulation – Enhanced stability and consistency
• Complete documentation – Full analytical data with each batch
• Technical support – Knowledgeable assistance for research design

Service Excellence:

• Fast USA shipping – Most orders processed within 24-48 hours
• Discreet packaging – Plain exterior with research-use labeling
• Documentation access – Batch-specific COA available upon request
• Research compliance – Strict adherence to laboratory-use guidelines

Comparative Quality Analysis ⚖️

🌡️ Handling, Storage & Laboratory Protocols

Optimal Storage Conditions ❄️

• Primary storage: -20°C in airtight, light-resistant container with desiccant
• Working supply: 4°C for up to 30 days (minimize temperature fluctuations)
• Critical protection: Protect from light and moisture – hygroscopic properties
• Avoid extremes: Protect from excessive heat (>40°C) or repeated freeze-thaw
• Capsule integrity: Store in original packaging to prevent moisture absorption

Important Stability Notes: ⚠️

• Light sensitivity: Degrades when exposed to UV light
• Moisture absorption: Hygroscopic – requires desiccant protection
• Temperature sensitivity: Stable at -20°C, degrades more rapidly at room temperature
• Solution stability: Limited water solubility; DMSO solutions stable at -20°C for months

Laboratory Handling Guidelines 🧤

1. Temperature control: Work quickly when removing from cold storage
2. Moisture protection: Use in low-humidity environment when possible
3. Light protection: Use amber vials or work in low-light conditions
4. Personal protection: Gloves, lab coat, eye protection recommended
5. Accurate records: Document storage conditions, handling times, and usage

Research Protocol Considerations 🐭

When designing studies with MK-677:

• Dose optimization: Conduct pilot studies to determine effective ranges
• Administration timing: Consider circadian GH secretion patterns
• Duration planning: Account for delayed IGF-1 response (days to weeks)
• Control groups: Vehicle controls and dose-response groups
• Monitoring schedule: Regular measurement of GH, IGF-1, glucose, other parameters
• Endpoint selection: Align with primary mechanisms being studied

❓ Frequently Asked Questions (FAQs)

Q: Is MK-677 (Ibutamoren) a peptide?

A: No, MK-677 is not a peptide. It is a small synthetic molecule that acts as a non-peptide mimetic of ghrelin. Despite occasional categorization with peptides, it has completely different chemical properties (non-peptide structure), better oral bioavailability, and longer half-life compared to peptide growth hormone secretagogues like GHRP-6 or Ipamorelin.

Q: What is the difference between MK-677 and growth hormone (GH) injections?

A: MK-677 stimulates endogenous GH secretion through ghrelin receptor activation, maintaining natural pulsatile release patterns. Direct GH injection bypasses physiological regulation, creating non-physiological continuous exposure. This distinction is crucial for researchers studying natural GH regulation versus pharmacological replacement.

Q: How long does it take to see IGF-1 elevation in research models?

A: Unlike GH (which elevates within hours), IGF-1 increases gradually over days to weeks due to hepatic synthesis in response to GH stimulation. Research typically shows significant IGF-1 elevation within 7-14 days of consistent administration, with peak levels around 2-4 weeks in sustained studies.

Q: Does MK-677 affect appetite in research models?

A: Yes, as a ghrelin receptor agonist, MK-677 typically increases appetite in research models, similar to natural ghrelin. This effect is dose-dependent and can be a useful research parameter when studying energy balance, feeding behavior, or metabolic interventions.

Q: What analytical methods verify your MK-677 quality?

A: We use multiple orthogonal methods: HPLC for purity and impurity profiling, mass spectrometry for molecular identity, NMR spectroscopy for structural confirmation, optical rotation for enantiomeric purity, plus heavy metal screening, residual solvent analysis, and microbiological testing. Full documentation is provided.

Q: How should MK-677 capsules be stored for maximum stability?

A: Store at -20°C in original airtight containers with desiccant, protected from light. Working aliquots may be kept at 4°C for up to 30 days. Avoid repeated freeze-thaw cycles and always reseal containers immediately after use. Never store at room temperature for extended periods.

⚠️ Critical Compliance & Safety Information

Intended Use Statement 📋

MK-677 (Ibutamoren) is sold exclusively for laboratory research applications by qualified personnel in controlled settings. These products are:

• NOT for human or veterinary use
• NOT for consumption
• NOT intended as drugs, cosmetics, or dietary supplements
• NOT for diagnostic or therapeutic applications
• NOT for in-vivo human studies without appropriate regulatory approvals

Important Research Considerations: ⚠️

Endocrine Effects:

• GH/IGF-1 axis modulation: Significant endocrine system effects
• Glucose metabolism: Can affect insulin sensitivity and glucose tolerance
• Hormonal interactions: Potential effects on other endocrine axes

Research Ethics & Safety:

• Dose-dependent effects: Careful dose selection and monitoring essential
• Long-term studies: Consider potential receptor desensitization with chronic use
• Control groups: Essential for interpreting endocrine parameter changes

Regulatory Compliance: ⚖️

Researchers accept full responsibility for ensuring:

• All research complies with institutional guidelines and applicable regulations
• Personnel are properly trained in handling research compounds
• Documentation is maintained for all research purposes and protocols
• Materials are used only in approved laboratory facilities
• Ethical oversight is obtained where required for animal studies

🚀 Ordering Process & Customer Support

Streamlined Research Procurement 📦

1. Select Quantity – Based on research scope, duration, and model requirements
2. Secure Checkout – Multiple payment options including cryptocurrency
3. Order Confirmation – Immediate email with details and timeline
4. Fast Processing – Most research orders ship within 1-2 business days
5. Discreet Delivery – Plain packaging with research-use labeling
6. Documentation Access – Receive batch-specific COA upon request

Shipping & Logistics ✈️

• USA Domestic – 2-5 business days, FREE on orders over $300
• Express Options – Overnight and 2-day available for urgent needs
• International – Worldwide delivery to permitted research destinations
• Temperature Control – Insulated packaging with cold packs for stability
• Discreet Packaging – No external indications of contents
• Tracking Information – Real-time updates on shipment progress

Customer Support Services 💬

• Technical Consultation – Compound properties and research applications
• Protocol Discussion – Study design and methodological questions
• Order Assistance – Placement, tracking, and delivery support
• Documentation Requests – COA and analytical data access
• Compliance Guidance – Appropriate research use information
• Problem Resolution – Responsive handling of any order concerns

💎 Why Researchers Worldwide Trust Our MK-677

For investigators exploring growth hormone physiology, body composition regulation, or endocrine aging mechanisms, our pharmaceutical-grade MK-677 offers uncompromising quality and complete analytical documentation. With ≥98% purity, >99% enantiomeric purity, and batch-specific verification, we provide research materials suitable for publication-quality science.

Our cGMP manufacturing standards, rigorous quality control, and dedicated scientific support ensure you receive consistently reliable material for your important research. Whether you’re studying somatotropic axis function, investigating metabolic effects of GH elevation, or exploring ghrelin receptor pharmacology, our MK-677 provides the purity, consistency, and documentation necessary for robust, reproducible scientific investigation.

Ready to advance your endocrine or metabolic research with premium MK-677? Browse our complete selection of research compounds, review all documentation, and place your order with confidence today.

For laboratory research use only. Not for human consumption. All purchases subject to terms and conditions verifying research purpose.