L-Glutathione Peptide

KPV Peptide (Ac-KPV-NH2, α-MSH (11-13))

Welcome to buypeptidesonlineusa.com, your premier domestic source for high-purity research peptides. Our KPV peptide is the synthetic acetylated tripeptide (Ac-Lys-Pro-Val-NH2) corresponding to the C-terminal fragment (11-13) of α-melanocyte-stimulating hormone (α-MSH). It is a potent anti-inflammatory and cytoprotective agent, meticulously manufactured for advanced investigations into inflammatory bowel disease (IBD), intestinal barrier function, cellular stress responses, and immune modulation. As a bioactive fragment with a unique mechanism of action, KPV is an essential tool for researchers exploring gut health, inflammation, and regenerative pathways. We ensure your critical research is supported by uncompromising quality, transparency, and rapid fulfillment.

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⚠️ Important Research Compliance Notice

This product is intended strictly for laboratory research use only and is not for human consumption or veterinary use. This product is not a medicine, drug, or medical device. It has not been evaluated by the FDA. This peptide is sold for investigational purposes by qualified researchers and professionals only.

🔬 What is KPV Peptide?

KPV is a synthetic tripeptide composed of three amino acids in the sequence Lysine-Proline-Valine (Lys-Pro-Val) . It is the minimal bioactive C-terminal fragment of the larger neuropeptide α-melanocyte-stimulating hormone (α-MSH), corresponding to amino acids 11-13 . While α-MSH is a 13-amino acid peptide with broad anti-inflammatory effects, research has shown that its smaller tripeptide fragment, KPV, retains significant anti-inflammatory and cytoprotective activity, making it a more focused tool for studying these pathways .

The primary mechanisms of KPV's action are multifaceted:

• Inhibition of NF-κB Pathway: KPV potently inhibits the activation of nuclear factor-kappa B (NF-κB) , a master transcription factor that controls the expression of numerous pro-inflammatory genes, including cytokines like IL-1β, IL-6, and TNF-α . By suppressing NF-κB, KPV reduces the production of these inflammatory mediators at their source.
• Uptake via PepT1 Transporter: KPV is efficiently transported into cells by the H+-coupled oligopeptide transporter 1 (PepT1) . This is particularly significant for IBD research, as PepT1 expression is known to be upregulated in the inflamed colonic epithelium and in immune cells like macrophages during colitis . This allows KPV to be taken up preferentially by the very cells driving inflammation.
• Modulation of MAPK Pathways: KPV has been shown to inhibit the activation of mitogen-activated protein kinase (MAPK) signaling pathways, such as p38 and ERK, which are involved in inflammatory and stress responses .
• Reduction of Oxidative Stress: Research indicates that KPV can reduce the production of reactive oxygen species (ROS) and inhibit ROS-mediated cell death (pyroptosis), protecting cells like keratinocytes from environmental damage .

✅ Why Choose Buy Peptides Online USA for Your Research?

When you need to buy KPV peptide online, quality and consistency are non-negotiable. Here is why discerning researchers choose us:

• Verified Purity: We provide access to independent third-party Certificate of Analysis (COA) documents, confirming purity via High-Performance Liquid Chromatography (HPLC) exceeding 99% and identity via Mass Spectrometry (MS) .
• Acetylated Form (Ac-KPV-NH2): Our peptide is presented as Ac-KPV-NH2. N-terminal acetylation and C-terminal amidation are common modifications that protect the peptide from enzymatic degradation, enhancing its stability in biological assays.
• Optimal Storage & Handling: Our KPV is shipped in lyophilized form. For long-term stability, store desiccated at -20°C or below, protected from light and moisture .
• Domestic Shipping: As a USA-based supplier, we offer fast, reliable shipping. Orders typically arrive within 2-5 business days in discreet, temperature-controlled packaging.
• Research-Focused: We make no medical claims. Our service is built on integrity, providing accurately labeled products for legitimate scientific inquiry.

🔎 Product Specifications & Technical Data

To ensure your research parameters are met with precision, here are the verified technical specifications for our KPV peptide. Purity is a critical determinant of research accuracy, and our product meets the high standards expected by the scientific community.

🧪 Key Research Applications & Focus Areas

KPV's targeted mechanism makes it a powerful and precise tool across several advanced research fields.

• 🩺 Inflammatory Bowel Disease (IBD) & Gut Health: This is a primary application of KPV. Foundational research published in Gastroenterology demonstrated that oral administration of KPV reduces the incidence of colitis in two different mouse models (DSS and TNBS), decreasing pro-inflammatory cytokine expression . Its ability to be taken up via PepT1, which is overexpressed in the inflamed colon, makes it a targeted probe for studying interventions in ulcerative colitis and Crohn's disease . Recent studies also show KPV helps restore the expression of tight junction proteins (Claudin-5, Occludin-1, ZO-1), enhancing intestinal barrier integrity .

• 🛡️ Inflammation & Immune Modulation: KPV is used to study the downregulation of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) and the modulation of immune cell function, including macrophages and T-lymphocytes . It has been shown to induce hapten-specific tolerance in models of contact hypersensitivity, an effect mediated by the generation of IL-10-producing T lymphocytes .

• 🧬 Skin Biology & Dermatological Research: KPV demonstrates protective effects in skin cells. A 2025 study published in Tissue & Cell found that KPV mitigates fine dust-induced keratinocyte apoptosis and inflammation by regulating oxidative stress and modulating the MAPK/NF-κB pathway . It also elevates intracellular calcium in keratinocytes via the melanocortin-1 receptor (MC-1R), a key pathway for skin homeostasis .

• 💊 Advanced Drug Delivery Research: Due to its inherent stability and anti-inflammatory properties, KPV is a model peptide for developing novel oral delivery systems. Recent research in Science Advances used KPV to develop a self-immolative peptide prodrug conjugate (SIPPC) that achieves 3.8-fold greater accumulation in inflamed colon tissue compared to free KPV . This highlights its role in cutting-edge pharmaceutical research.

• ⚗️ Cellular Stress & Apoptosis: KPV is used to study pyroptosis (inflammatory cell death). It has been shown to block ROS-mediated caspase-1 activation, reducing IL-1β secretion and protecting cells from inflammatory cell death .

📝 Handling, Storage, and Preparation for Research

Proper handling is critical to maintaining peptide integrity and ensuring experimental validity.

• Receiving & Storage: Upon receipt, store the lyophilized vial in a freezer at -20°C (-4°F) or below. Protect from light and moisture. Lyophilized KPV is stable for up to 36 months under these conditions .
• Reconstitution: To prepare stock solutions, KPV is soluble in sterile water or bacteriostatic water . Allow the peptide to warm to room temperature in a desiccator before opening. Gently swirl or invert to dissolve; do not vortex.
• Dosage Considerations:
  • In vitro: Studies have used concentrations in the nanomolar (e.g., 10 nM) to micromolar range. For example, 10 nM KPV significantly decreased IL-1β-induced NF-κB activity in Caco-2 cells .
  • In vivo (Rodent): For colitis studies, KPV has been administered orally via drinking water or through targeted conjugates at doses ranging from micrograms to milligrams per mouse .
• Preventing Adsorption: At low concentrations, peptides can adsorb to plastic surfaces. Using low-protein-binding tubes is recommended.
• Safety & Handling: Always use personal protective equipment (PPE) such as gloves and safety goggles when handling. Work in a laminar flow hood or well-ventilated area. Dispose of all waste in appropriate biohazard containers.

❓ Frequently Asked Questions (FAQ)

Q1: What is the difference between KPV and full-length α-MSH?

A: KPV is the minimal bioactive fragment of α-MSH, consisting of only its last three amino acids (11-13) . While α-MSH has broader effects, KPV retains significant anti-inflammatory properties, making it a more focused tool for studying specific pathways like NF-κB inhibition and PepT1-mediated uptake .

Q2: What is the significance of the PepT1 transporter in KPV research?

A: KPV is transported into cells by PepT1 . This is crucial for IBD research because PepT1 is overexpressed in the inflamed colon and in immune cells during colitis. Therefore, KPV can be preferentially delivered to the sites of active inflammation, providing a level of targeted action .

Q3: How do I verify the quality of your KPV?

A: We are committed to transparency. Our product listings provide access to a third-party Certificate of Analysis (COA) . This document validates the compound's identity via Mass Spectrometry (MS) and its purity via High-Performance Liquid Chromatography (HPLC), which is ≥99% .

Q4: What is the correct way to store KPV after reconstitution?

A: For short-term use (2-7 days), store the solution at 2-8°C. For longer storage, it is essential to aliquot the solution into single-use vials and freeze at -20°C or below. Avoid repeated freeze-thaw cycles .

Q5: What research areas is KPV commonly used in?

A: It is primarily used in inflammatory bowel disease (IBD) research, gastroenterology, dermatology (skin inflammation), immunology, and advanced drug delivery .

📦 Our Services & Guarantees

• 24/7 Customer Support: Our team is available to answer your pre- and post-sales questions.
• Authenticity Guarantee: We guarantee that you receive the exact product described, with full documentation and lot matching.
• Product Replacement: In the unlikely event of damage during shipping, we have a clear process for claims and replacement.
• Technical Consultation: Contact us for assistance with solubility or handling protocols.

🚀 How to Buy KPV Peptide Online

Purchasing from buypeptidesonlineusa.com is simple and secure.

1. Browse & Select: Choose the quantity you need (e.g., 1mg, 5mg, 10mg vial).
2. Add to Cart: Proceed to our secure checkout.
3. Payment: We accept major credit cards and cryptocurrency (Bitcoin, Ethereum, USDT) for privacy and convenience.
4. Shipping: Orders are processed within 24 hours on business days and shipped in discreet, temperature-controlled packaging. Domestic orders typically arrive in 2-5 days.

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