Kisspeptin-10 Peptide

Kisspeptin-10 Peptide (Kp-10, Metastin)

Welcome to buypeptidesonlineusa.com, your premier domestic source for high-purity research peptides. Our Kisspeptin-10 (Kp-10) is the synthetic 10-amino acid peptide corresponding to the biologically active, C-terminal fragment of the Kisspeptin (Metastin) protein. It is a potent and specific agonist of the KISS1 receptor (KISS1R, also known as GPR54), making it an essential tool for advanced investigations into reproductive neuroendocrinology, puberty, hypothalamic function, and the regulation of gonadotropin secretion. We ensure your critical research is supported by uncompromising quality, transparency, and rapid fulfillment.

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⚠️ Important Research Compliance Notice

This product is intended strictly for laboratory research use only and is not for human consumption or veterinary use. This product is not a medicine, drug, or medical device. It has not been evaluated by the FDA. This peptide is sold for investigational purposes by qualified researchers and professionals only.

🔬 What is Kisspeptin-10 Peptide?

Kisspeptin-10 (Kp-10) is a synthetic decapeptide with the amino acid sequence Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 . It is the shortest and most biologically potent fragment of the endogenous peptide kisspeptin, which is encoded by the KISS1 gene . The full-length kisspeptin (also known as Metastin for its ability to suppress cancer metastasis) can be processed into shorter, biologically active fragments, with Kp-10 representing the minimal sequence required for full activation of its receptor .

The discovery of the KISS1 gene and its product, kisspeptin, revolutionized the field of reproductive biology. It was found that mutations in the gene for its receptor, KISS1R (or GPR54), cause a failure to undergo puberty (idiopathic hypogonadotropic hypogonadism) . This established kisspeptin as a master, non-redundant regulator of the reproductive axis.

Kisspeptin-10 exerts its effects by binding to the KISS1 receptor (KISS1R/GPR54), a G-protein-coupled receptor (GPCR), located on the surface of neurons that produce gonadotropin-releasing hormone (GnRH) in the hypothalamus . Upon activation, it powerfully and dose-dependently stimulates the secretion of GnRH, which in turn triggers the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH) . This places Kp-10 at the very apex of the reproductive hormone cascade, making it an indispensable probe for studying the central control of fertility.

✅ Why Choose Buy Peptides Online USA for Your Research?

When you need to buy Kisspeptin-10 peptide online, quality and consistency are non-negotiable. Here is why discerning researchers choose us:

• Verified Purity: We provide access to independent third-party Certificate of Analysis (COA) documents, confirming purity via High-Performance Liquid Chromatography (HPLC) exceeding 98% and identity via Mass Spectrometry (MS) .
• Optimal Storage & Handling: Our Kp-10 is shipped in lyophilized form. For long-term stability, store desiccated at -20°C or below, protected from light and moisture .
• Domestic Shipping: As a USA-based supplier, we offer fast, reliable shipping. Orders typically arrive within 2-5 business days in discreet, temperature-controlled packaging.
• Research-Focused: We make no medical claims. Our service is built on integrity, providing accurately labeled products for legitimate scientific inquiry.
• Secure Transactions: Enjoy peace of mind with secure checkout and multiple payment options, including credit cards and cryptocurrency.

🔎 Product Specifications & Technical Data

To ensure your research parameters are met with precision, here are the verified technical specifications for our Kisspeptin-10 peptide.

🧪 Key Research Applications & Focus Areas

Kisspeptin-10's central role as a GnRH secretagogue makes it an indispensable tool across reproductive neuroscience and endocrinology.

• 🧬 Puberty & Reproductive Maturation: Kp-10 is the primary tool for studying the mechanisms that trigger the onset of puberty. Researchers use it to model the reactivation of GnRH neurons after a quiescent period in juvenile life and to investigate how genetic or environmental factors can lead to precocious (early) or delayed puberty .
• 🔄 GnRH Neuron Physiology: It is used extensively to study the function and responsiveness of GnRH neurons in vivo and in vitro. By applying Kp-10 to hypothalamic explants or brain slices, researchers can directly measure GnRH secretion, calcium flux in neurons, and the electrical properties that govern GnRH pulsatility .
• ⚕️ Fertility & Infertility Research: Kp-10 is a critical tool for investigating causes of infertility, particularly those originating at the hypothalamic level. It is used to model conditions like hypothalamic amenorrhea (where stress, low body weight, or exercise suppress the reproductive axis) and to explore how kisspeptin signaling is modulated by metabolic status and sex steroids .
• 🧪 Metabolic-Endocrine Integration: Research has firmly linked metabolism and reproduction. Kp-10 is used to study how metabolic cues (like leptin, insulin, and glucose levels) are integrated at the level of the hypothalamus to control GnRH and thus fertility. This is crucial for understanding disorders like polycystic ovary syndrome (PCOS) and obesity-related infertility .
• 🕰️ Aging & Reproductive Senescence: Changes in the kisspeptin system are implicated in reproductive aging. Kp-10 is used to probe the responsiveness of the hypothalamic-pituitary-gonadal (HPG) axis in aged animal models to determine if the decline in fertility is due to a failure at the level of the kisspeptin neuron, the GnRH neuron, or the pituitary.

🔬 How Does Kisspeptin-10 Work? (Mechanism of Action)

Kisspeptin-10 acts as the central gatekeeper of the reproductive axis.

• Receptor Binding: Kp-10 binds with high affinity and specificity to the KISS1 receptor (KISS1R, GPR54) , a Gq/11-coupled GPCR expressed on the surface of GnRH neurons in the hypothalamus .
• Intracellular Signaling: Receptor activation stimulates phospholipase C (PLC), leading to the production of inositol trisphosphate (IP3) and diacylglycerol (DAG). This results in the release of calcium ions (Ca²⁺) from intracellular stores and activation of protein kinase C (PKC) .
• Neuronal Excitation: The increase in intracellular calcium and PKC activity leads to the depolarization and increased firing rate of GnRH neurons .
• GnRH Release: This neuronal excitation triggers the secretion of GnRH from the nerve terminals in the median eminence into the hypothalamic-pituitary portal circulation. GnRH then travels to the anterior pituitary to stimulate the release of LH and FSH.

📝 Handling, Storage, and Preparation for Research

Proper handling is critical to maintaining peptide integrity and ensuring experimental validity.

• Receiving & Storage: Upon receipt, store the lyophilized vial in a freezer at -20°C (-4°F) or below. Protect from light and moisture.
• Reconstitution: To prepare stock solutions, allow the peptide to warm to room temperature in a desiccator. Reconstitute in sterile distilled water to a known concentration (e.g., 1 mg/mL). Gently swirl or invert to dissolve; do not vortex.
• Dosage Considerations:
  • In vivo (Rodent): Effective doses for stimulating LH secretion range from micrograms per kilogram (e.g., 1-50 nmol per animal) administered via intracerebroventricular (ICV) or intravenous (IV) injection .
  • In vitro: Concentrations in the nanomolar range (e.g., 10-100 nM) are typically used to stimulate GnRH secretion or neuronal activity in hypothalamic explants or cell cultures .
• Preventing Adsorption: At low concentrations, peptides can adsorb to plastic surfaces. Using low-protein-binding tubes and siliconized tips is recommended.
• Safety & Handling: Always use personal protective equipment (PPE) such as gloves and safety goggles when handling. Dispose of all waste in appropriate biohazard containers.

❓ Frequently Asked Questions (FAQ)

Q1: What is the difference between Kisspeptin and Kisspeptin-10?

A: Kisspeptin is the full-length protein product of the KISS1 gene (145 amino acids). It can be cleaved into smaller, biologically active fragments, with Kisspeptin-10 (Kp-10) being the shortest C-terminal fragment that retains full potency and efficacy at the KISS1 receptor. It is often the preferred tool for research due to its high activity and ease of synthesis.

Q2: What is the primary function of Kisspeptin-10 in research?

A: Its primary function is to act as a potent and direct stimulator of gonadotropin-releasing hormone (GnRH) secretion. It is the master tool for studying the central nervous system control of puberty and fertility.

Q3: How do I verify the quality of your Kisspeptin-10?

A: We are committed to transparency. Our product listings provide access to a third-party Certificate of Analysis (COA) . This document validates the compound's identity via Mass Spectrometry (MS) and its purity via High-Performance Liquid Chromatography (HPLC), which is ≥98% .

Q4: Is Kisspeptin-10 the same as Metastin?

A: Yes, kisspeptin is also known as metastin because the KISS1 gene was originally identified for its ability to suppress cancer metastasis. Kisspeptin-10 is the active core of this protein.

Q5: How should I store Kisspeptin-10 after reconstitution?

A: After reconstitution, it is essential to aliquot the solution into single-use vials and store them at -20°C or below. Avoid repeated freeze-thaw cycles, as this degrades the peptide. For short-term use (a few days), it can be stored at 4°C.

📦 Our Services & Guarantees

• 24/7 Customer Support: Our team is available to answer your pre- and post-sales questions.
• Authenticity Guarantee: We guarantee that you receive the exact product described, with full documentation and lot matching.
• Product Replacement: In the unlikely event of damage during shipping, we have a clear process for claims and replacement.
• Technical Consultation: Contact us for assistance with solubility or handling protocols.

🚀 How to Buy Kisspeptin-10 Peptide Online

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1. Browse & Select: Choose the quantity you need (e.g., 1mg, 5mg vial).
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