Ipamorelin, CJC-1295 no DAC (Blend)

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Unlocking Selective Synergy: The Ipamorelin and CJC-1295 no DAC Peptide Blend 🔬

For researchers focused on the nuanced architecture of the Growth Hormone (GH) axis, the Ipamorelin, CJC-1295 no DAC (Blend) represents a gold-standard research tool. This pre-formulated combination unites a highly selective growth hormone secretagogue (GHS) with a physiologically relevant growth hormone-releasing hormone (GHRH) analog to explore their theorized synergistic effects on somatotropic signaling in a controlled, pulsatile manner .

Instead of sourcing and dosing these peptides separately, this blend provides a consistent ratio, reducing variables in your experimental protocols. This dual-action approach allows for a nuanced examination of how selective GHS-R1a activation (via Ipamorelin) and GHRH receptor stimulation (via CJC-1295 no DAC) integrate to influence GH pulsatility, downstream effector molecules like IGF-1, and broader metabolic pathways without the confounding factors associated with less selective compounds .

What is Ipamorelin and CJC-1295 no DAC?

• Ipamorelin: A synthetic pentapeptide and highly selective agonist of the growth hormone secretagogue receptor (GHS-R1a) , also known as the ghrelin receptor. Often described as a “selective GHS,” Ipamorelin is distinguished by its focused mechanism of action. Research suggests it stimulates GH release with minimal effect on other hormones like cortisol, prolactin, or ACTH, making it a precise tool for studying targeted GH secretion pathways without broad endocrine disruption . Its molecular formula is C₃₈H₄₉N₉O₅ with a molecular weight of approximately 711.9 g/mol .
• CJC-1295 without DAC (Drug Affinity Complex): Often referred to as Modified GRF (1-29) , this peptide is a synthetic analog of endogenous GHRH . The “no DAC” version has a relatively short half-life (approximately 30 minutes to an hour) compared to its DAC-bound counterpart . This shorter activity window is theorized to stimulate GH release in a more physiological, pulsatile pattern, which is crucial for studying natural GH pulse dynamics and avoiding potential receptor desensitization associated with the continuous (“bleed”) stimulation caused by long-acting analogs . Its molecular formula is C₁₅₂H₂₅₂N₄₄O₄₂ with a molecular weight of approximately 3367.9 g/mol .

🔬 Primary Research Focuses and Applications

The Ipamorelin & CJC-1295 no DAC Blend is primarily utilized in scientific research to investigate:

• Pulsatile GH Release and Axis Restoration: This blend is considered a foundational tool for “pulsatile restoration” research . By combining a selective GHS with a short-acting GHRH analog, researchers can model the body’s natural, episodic release of GH, which is essential for studying endocrine feedback loops, circadian rhythms, and the physiological effects of GH pulses versus continuous exposure .
• Dual-Pathway GPCR Signaling and Synergy: Studying how a selective GHS-R1a agonist (Ipamorelin) and a GHRH-R agonist (CJC-1295) work together to amplify GH pulses. This allows for the investigation of signal integration, second-messenger kinetics (such as cAMP/PKA pathways), and receptor cross-talk at the cellular level .
• Metabolic Regulation and Body Composition: Exploring the role of enhanced GH-IGF-1 signaling in lipid metabolism (lipolysis), protein synthesis, and the regulation of energy balance. The selective nature of Ipamorelin makes this blend particularly useful for isolating the metabolic effects of GH from other stress-related hormonal changes .
• Recovery, Repair, and Cellular Regeneration: Investigating the anabolic signals that contribute to tissue recovery, muscle protein synthesis, joint function, and cellular repair mechanisms following stress or injury models .
• Comparative Pharmacology and Receptor Selectivity: Utilizing Ipamorelin’s high selectivity as a benchmark to compare against other GHSs (like GHRP-2 or GHRP-6) in studies mapping receptor-ligand interactions, functional selectivity, and downstream signaling cascades .

🧪 Product Specifications & Technical Data

At Buy Peptides Online USA, we ensure your research is built on a foundation of quality and consistency. This blend is manufactured to rigorous laboratory standards and verified through advanced analytical methods.

✅ Why Choose Buy Peptides Online USA for Your Research?

Sourcing reliable research compounds is critical for reproducible, high-impact science. Here is why researchers across the USA trust us:

• Verified Purity & Potency: We provide access to Certificates of Analysis (COA) and rely on advanced analytical methods like High Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to confirm the molecular weight and purity (>99%) of every batch . This commitment ensures the integrity of your experimental data.
• Research-Focused Integrity: We strictly adhere to research-use-only (RUO) guidelines. Our product descriptions are factual, focusing on chemical properties and cited research applications, never unverified human-use claims .
• Fast & Discreet USA Shipping: We offer fast, reliable shipping across the United States with discreet packaging to ensure your order arrives safely, professionally, and on time for your critical research timelines. Enjoy free shipping on orders over $300.
• Expert Support & Authenticity Guarantee: Our team provides technical consultation to support your work. We stand behind the authenticity and quality of all our products, offering a product replacement service and clear complaint handling.

📝 Handling, Storage, & Important Safety Information

• Handling & Reconstitution: This product is for laboratory use only by qualified professionals. Use proper aseptic technique. Reconstitute by injecting the diluent (e.g., bacteriostatic water) slowly against the inner wall of the vial to prevent foaming. Swirl gently—do not shake, as this can damage the peptide structure .
• Safety: Always wear appropriate personal protective equipment (PPE), including lab coats, gloves, and safety glasses. Dispose of any sharps and biological waste according to your institutional guidelines .
• Stability Considerations: Lyophilized peptides are stable when stored desiccated at -20°C or below . Once reconstituted, peptides are significantly less stable and should be refrigerated and used promptly. Avoid repeated freeze-thaw cycles at all costs, as these can lead to peptide degradation and reduced bioactivity .
• Warning: This product is not for human or veterinary use. It is not a drug, food, or cosmetic. Do not ingest or inject .

❓ Frequently Asked Questions (FAQs)

Q: What is the primary research advantage of blending Ipamorelin with CJC-1295 no DAC?

A: The blend combines the highly selective GHS-R1a-mediated GH release of Ipamorelin with the physiological, pulsatile GHRH stimulation of CJC-1295 no DAC . This dual-pathway activation allows researchers to study a more refined and naturalistic model of GH axis regulation, minimizing off-target endocrine effects often associated with less selective GHSs .

Q: What is the difference between CJC-1295 with DAC and without DAC, and why is “no DAC” preferred in this blend?

A: The presence of DAC (Drug Affinity Complex) significantly extends the peptide’s half-life in a research model (to about 8 days), leading to a continuous, non-physiological elevation of GH levels, sometimes referred to as a “GH bleed” . CJC-1295 no DAC has a much shorter half-life (around 30 minutes to an hour) and is theorized to stimulate GH release in a more natural, pulsatile fashion, which is essential for studies aiming to mimic endogenous secretion patterns and avoid potential receptor desensitization . This blend uses the no DAC version specifically for this reason.

Q: What makes Ipamorelin “selective” compared to other GHRPs like GHRP-6?

A: Ipamorelin is characterized as a “selective GHS” because research suggests it stimulates GH release with minimal effect on other pituitary hormones such as adrenocorticotropic hormone (ACTH), prolactin, or cortisol . This focused receptor profile makes it a valuable tool for studying GH-specific pathways without the confounding variables of broader endocrine activation seen with compounds like GHRP-6 .

Q: How do you verify the purity of the blend?

A: We ensure every batch is rigorously analyzed using High Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) . HPLC confirms a purity level of ≥99% for each component, while Mass Spectrometry verifies the precise molecular weight of both Ipamorelin (~711.9 g/mol) and CJC-1295 (~3367.9 g/mol), ensuring the correct peptide structure and identity .

Q: What are the critical storage conditions for this lyophilized peptide?

A: Upon arrival, store the lyophilized powder in a freezer at -20°C (-4°F) or lower. It is crucial to keep it desiccated, protected from light, and to avoid repeated freeze-thaw cycles, as these can lead to peptide degradation and reduced bioactivity . Once reconstituted, store at 2-8°C and use promptly.

Q: Is this peptide blend prohibited in sports research?

A: Yes, researchers should be aware that both Ipamorelin and CJC-1295 are classified as peptide hormones, releasing factors, and secretagogues, and are included on the World Anti-Doping Agency (WADA) Prohibited List. They are subject to detection in doping control analyses and are intended for legitimate scientific research only.

Ready to Advance Your Research? 🚀

Equip your laboratory with a trusted research tool. Order the high-purity Ipamorelin, CJC-1295 no DAC (Blend) today from Buy Peptides Online USA. Benefit from our fast USA shipping, secure payments (including crypto), and the confidence that comes from rigorously tested research compounds. For any questions about this product or your order, our support team is here to provide technical consultation.