IGF-1 LR3 Peptide

🚀 The Premier Long-Acting Growth Factor for Research: High-Purity IGF-1 LR3 Peptide for Extended-Duration Cellular Studies

Welcome to the leading destination for premium IGF-1 LR3 Peptide, the engineered, long-acting analog that has become a fundamental reagent in modern cell biology and tissue research laboratories. 🌟 At Buy Peptides Online USA, we provide researchers with access to meticulously synthesized and independently verified growth factors, designed to deliver consistent, potent signaling in the most demanding experimental models. This detailed technical resource offers everything you need to successfully integrate IGF-1 LR3 into your research protocols, from its unique structural advantages and precise specifications to specialized handling guidelines that preserve its critical bioactivity. Our ethos is defined by analytical transparency, cGMP-compliant sourcing, and an absolute dedication to research-only applications, ensuring you receive a reliable and powerful tool to drive your scientific inquiries forward.

🛒 Optimize your cell culture assays. Click to add high-purity IGF-1 LR3 Peptide to your cart. Enjoy fast USA shipping and free delivery on all orders over $300! ✔

🧬 What is IGF-1 LR3 Peptide?

IGF-1 LR3 Peptide (Long R3 Insulin-like Growth Factor-I) is a recombinantly produced, 83-amino acid analog of human IGF-1, purposefully modified to overcome key limitations of the native hormone in experimental systems. Its design includes a 13-amino acid N-terminal extension and a critical amino acid substitution (Arg for Glu at position 3).

These intentional modifications create a research tool with distinct advantages. The altered structure severely diminishes its binding affinity for Insulin-like Growth Factor Binding Proteins (IGFBPs), which normally sequester and inactivate IGF-1. This results in a significantly higher concentration of free, receptor-available peptide in cell culture environments. Consequently, IGF-1 LR3 exhibits a greatly extended functional half-life and enhanced potency in vitro compared to standard IGF-1. For researchers, this translates to more sustained cellular stimulation, reduced need for frequent media supplementation, and more robust effects in multi-day assays focused on differentiation, hypertrophy, and long-term cell survival. 🧫

📊 IGF-1 LR3 Peptide: Complete Product Specifications & Analysis

For research that cannot compromise on quality, here is the exhaustive analytical profile of our IGF-1 LR3 Peptide.

⚙️ Primary Research Functions & Experimental Applications

IGF-1 LR3 is a cornerstone molecule in laboratories investigating sustained trophic signaling, tissue development, and cellular repair mechanisms. Its engineered properties make it uniquely suited for chronic exposure paradigms.

🔍 Typical Research Focuses Include:

• Muscle Cell Hypertrophy & Differentiation Studies: Long-term culture of skeletal myoblasts (e.g., C2C12, L6) to assess cumulative effects on myotube formation, size, and the expression of contractile proteins. 💪
• Neurotrophic Support & Neurite Outgrowth Assays: Extended-duration studies using neuronal cell lines (e.g., PC12) or primary neurons to investigate effects on cell survival, neurite extension, and branching in models of neuroprotection. 🧠
• Cartilage & Bone Tissue Engineering: Research in chondrocyte and osteoblast cultures exploring the sustained anabolic effects on extracellular matrix synthesis (collagen, proteoglycans) and mineralization. 🦴
• Stem Cell Research & Lineage Specification: Investigations into the role of prolonged IGF-1R activation in maintaining pluripotency or guiding the differentiation of mesenchymal and other stem cells into specific lineages.
• Mechanistic Signaling Pathway Analysis: A highly effective ligand for studying the temporal dynamics of IGF-1 receptor activation, downstream phosphorylation events (AKT, ERK), and gene expression changes over 24-72 hour periods.

⚠️ Critical Research Notice: The applications outlined are established avenues of scientific investigation for this well-characterized research reagent. IGF-1 LR3 Peptide is sold strictly as a research chemical for controlled, non-clinical laboratory studies. This product is not a drug, dietary supplement, or cosmetic ingredient and is not intended for human or veterinary use of any kind.

✅ Why Choose Our IGF-1 LR3 Peptide for Your Laboratory?

Choosing to order IGF-1 LR3 Peptide online from our USA-based supply platform means selecting a partner dedicated to the rigor and reproducibility of growth factor research. Here is our definitive value proposition:

• Guaranteed Purity & Identity Verification: We eliminate guesswork. Each batch is analytically confirmed via independent High-Performance Liquid Chromatography (HPLC) for purity and Mass Spectrometry (MS) for precise molecular weight verification, ensuring you receive the authentic, bioactive analog.
• Specialized for Long-Duration Cell Culture: The inherent stability and extended half-life of IGF-1 LR3 provide more consistent biological stimulation in multi-day experiments, leading to more reliable and reproducible data in complex assays like myotube differentiation or neurite outgrowth.
• Unwavering Commitment to Research Integrity: We market exclusively to the scientific community. Our labeling is precise, our claims are evidence-based, and we operate with full compliance regarding the sale of materials for laboratory investigation only.
• Optimized Cold-Chain Shipping & Discreet Delivery: We understand the sensitivity of proteins. Your peptide is shipped with ample cold packs or dry ice in insulated packaging, ensuring stability from our door to your lab. Free shipping is provided on all domestic orders over $300.
• Expert Support & Flexible, Secure Ordering: Our team is available for technical consultation on reconstitution and application specifics. Complete your purchase confidently with major credit cards or our secure, anonymous cryptocurrency payment option (Bitcoin, Ethereum, USDT accepted).

👉 Click ‘Add to Cart’ to procure your supply of high-performance IGF-1 LR3 Peptide. Elevate your cell culture research with a reagent of proven consistency.

🧫 Advanced Handling, Reconstitution & Cell Culture Protocol

⚠️ ATTENTION: IGF-1 LR3 is a large, structured protein. Incorrect handling will cause aggregation, loss of solubility, and complete inactivation. Adhere to this protocol without deviation.

1. Pre-Experiment Preparation: Pre-chill a vial of sterile 10mM HCl or 0.1M acetic acid on ice. Ensure you have sterile, low-protein-binding microcentrifuge tubes ready for aliquoting.
2. Storage Upon Receipt: Immediately upon arrival, transfer the unopened vial to a -80°C freezer. For long-term storage (beyond 6 months), -80°C is mandatory to preserve full integrity. A -20°C freezer is acceptable for short-term, active use.
3. Initial Reconstitution (The Most Critical Step): THIS STEP IS NON-NEGOTIABLE. Remove the vial from the freezer and place it on ice. Using a chilled pipette, gently add the pre-chilled acidic solvent down the inner wall of the vial. DO NOT DIRECTLY HIT THE LYOPHILIZED CAKE. Cap the vial and let it sit undisturbed on ice for 30-60 minutes. After this period, gently swirl or tilt the vial until the powder is fully dissolved. NEVER VORTEX OR SHAKE VIGOROUSLY. The final solution should be crystal clear.
4. Immediate Aliquoting & Stock Creation: Assuming a 1 mg vial reconstituted in 1 mL of acid, you now have a 1 mg/mL primary stock. IMMEDIATELY aliquot this primary stock into small, single-use volumes (e.g., 10 µL or 20 µL) into pre-chilled tubes. Seal tightly and place all aliquots directly into a -80°C freezer.
5. Preparing Working Media for Experiments: On the day of your experiment, remove one aliquot and thaw it on ice. Using sterile technique, add the thawed aliquot directly to your pre-warmed, pH-buffered cell culture medium to achieve your desired final working concentration. The small volume of acid will be neutralized by the medium’s buffering capacity.

👩‍🔬 Essential Laboratory Safety & Best Practices:

• This product is for use by qualified personnel in a controlled laboratory environment.
• Standard PPE (lab coat, gloves, safety glasses) is required. Perform all open-vial steps in a laminar flow hood using aseptic technique.
• Utilize low-protein-binding pipette tips and tubes exclusively to prevent significant peptide loss through surface adsorption.
• Decontaminate all waste materials according to your institution’s chemical and biological waste management protocols.

🚫 WARNING: FOR LABORATORY RESEARCH USE ONLY. NOT FOR HUMAN OR VETERINARY USE. IGF-1 LR3 Peptide is a potent research-grade growth factor analog. It is intended solely for controlled in-vitro (cell culture) or ex-vivo experimental applications. It is not for injection, ingestion, or any form of human or animal administration. It is not a dietary supplement, performance enhancer, or therapeutic agent.

📦 Specialized Packaging, Shipping & Service Guarantee

• Guaranteed Temperature-Controlled Shipping: Your IGF-1 LR3 Peptide is sealed under inert gas, packaged with desiccant, and shipped in high-performance insulated containers with sufficient frozen gel packs or dry ice to maintain a frozen state during transit. All packages are plain and discreet.
• Rapid USA & International Research Logistics: We offer priority USA shipping with full tracking. International shipping to qualified research institutions is available, complete with all required customs documentation.
• Our Service Commitment: Your purchase is protected by our authenticity guarantee, backed by the batch-specific CoA. We provide responsive 24/7 support for order tracking and a clear product replacement policy for any issue verified upon delivery.

❓ Frequently Asked Questions (FAQs)

Q1: How is your IGF-1 LR3 different from the “Receptor Grade” version?

A1: Both products contain the same high-purity IGF-1 LR3 analog. The “Receptor Grade” designation indicates additional validation steps confirming optimal folding for the most sensitive binding assays. This standard IGF-1 LR3 Peptide is of the same ≥98% HPLC purity and is perfectly suited for the vast majority of cell culture and functional assays, offering exceptional value for core research applications.

Q2: What happens if I accidentally reconstitute in sterile water or PBS?

A2: Reconstitution in a neutral-pH solution will very likely cause immediate and irreversible aggregation. The peptide will appear cloudy or form a precipitate, and its bioactivity will be permanently lost. Always use a weak acidic solvent (10mM HCl or 0.1M acetic acid) for the initial dissolution.

Q3: Can you suggest a starting concentration for my cell type?

A3: As a supplier of research chemicals, we cannot provide specific dosage or concentration guidance. The effective concentration is highly dependent on your cell type, assay duration, and desired outcome. You must consult the relevant scientific literature for your specific model system and perform initial optimization experiments (e.g., a dose-response curve) to determine the ideal concentration, which often falls within a 10-100 ng/mL range.

Q4: Is IGF-1 LR3 the same as regular IGF-1?

A4: No, they are distinct. Regular (native) IGF-1 is a 70-amino acid protein with high binding protein affinity and a short half-life in culture. IGF-1 LR3 is an 83-amino acid engineered analog with reduced binding protein affinity, resulting in greater bioavailability, potency, and a significantly extended half-life in experimental systems, making it preferable for many extended-duration in-vitro studies.

Q5: Do you offer discounts for bulk or recurring lab orders?

A5: Yes, we do. We provide competitive bulk pricing for core facilities, academic labs, and commercial research teams with ongoing needs. Please contact our sales team directly through the website to discuss volume discounts and set up a standing order agreement.

📝 How to Order & Final Researcher Notes

IGF-1 LR3 Peptide is an essential reagent for contemporary research requiring sustained growth factor signaling. By selecting our analytically verified product, you are securing a critical component for robust, reproducible cellular assays.

To place your research order:

1. Select the desired quantity of IGF-1 LR3 Peptide.
2. Click “Add to Cart” and review your selections.
3. Proceed to our secure checkout to enter shipping and payment details.
4. Confirm your order to receive instant email confirmation.

We are committed to empowering scientific discovery. For bulk orders, institutional purchase orders, or in-depth technical consultation on integrating this peptide into your specific research workflow, please reach out to our dedicated support team.

Disclaimer: All information presented is for educational and descriptive purposes regarding the research compound’s properties. It is not safety, procedural, or dosage advice. Purchasers are solely responsible for ensuring their purchase and use comply with all applicable local, state, federal, and institutional regulations. This product is for use by trained professionals in a controlled laboratory setting only.