hGH Fragment 176-191

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Unlocking Selective Metabolic Pathways: An Introduction to hGH Fragment 176-191 Peptide 🔬

For researchers focused on the complex architecture of metabolic regulation and cellular signaling, hGH Fragment 176-191 represents a uniquely selective and powerful research tool. This synthetic peptide, corresponding to a 16-amino acid sequence near the C-terminal end of the human growth hormone (hGH) molecule, has attracted significant scientific interest for its theorized ability to isolate specific metabolic properties of hGH without engaging its broader systemic effects .

Often referred to as AOD-9604 (Anti-Obesity Drug 9604) in research literature, this fragment was originally developed to investigate the lipolytic domain of growth hormone . What makes Fragment 176-191 especially intriguing for researchers is its hypothesized selective profile—it appears to interact with pathways involved in lipid mobilization and energy turnover while exhibiting minimal impact on insulin-like growth factor-1 (IGF-1) levels or blood glucose regulation, distinguishing it from full-length hGH in experimental models .

What is hGH Fragment 176-191?
hGH Fragment 176-191 is a synthetic peptide consisting of amino acids 176 through 191 of the human growth hormone sequence. It contains a disulfide bridge between cysteine residues at positions 7 and 14, which is critical for maintaining its structural integrity and bioactivity in research applications . Early foundational research by Ng and Bornstein demonstrated that fragments containing this region produced measurable effects on glucose and insulin dynamics in animal models, establishing the groundwork for decades of subsequent investigation .

🔬 Primary Research Focuses and Applications

The hGH Fragment 176-191 Peptide is utilized in scientific research to investigate a broad spectrum of metabolic and cellular questions:

• Lipid Metabolism and Lipolytic Pathways: The most extensively explored domain for Fragment 176-191 is its potential role in lipid metabolism. Research suggests the peptide may promote lipolysis (the breakdown of stored fat) while simultaneously inhibiting lipogenesis (the formation of new fat deposits) . These processes are critical for understanding energy balance, metabolic homeostasis, and the molecular mechanisms underlying fat oxidation. Studies indicate that Fragment 176-191 may activate lipolytic pathways through cAMP signaling without requiring interaction with the full hGH receptor .

• Cellular Signaling and Intracellular Pathways: Fragment 176-191 is increasingly employed in research aimed at decoding intracellular metabolic signals. It has been hypothesized that the peptide may interact with signaling proteins associated with energy stress responses, including AMP-activated protein kinase (AMPK) , a master regulator of cellular fuel status . Investigations also suggest potential modulation of the cAMP/PKA axis, a pathway central to lipid breakdown and the activation of metabolic enzymes, making the peptide a valuable probe for studying hormonal mimetics and selective metabolic triggers .

• Tissue Regeneration and Cartilage Research: Beyond metabolic regulation, emerging research has explored Fragment 176-191's potential relevance in regenerative science. Studies suggest the peptide may impact cellular repair processes, particularly in cartilage and connective tissues . Some investigations have examined its potential to support collagen synthesis and extracellular matrix remodeling, suggesting utility in exploring mechanisms of tissue regeneration and joint health .

• Mitochondrial Function and Energy Metabolism: Researchers have expressed interest in whether Fragment 176-191 might influence mitochondrial activity and cellular fuel preference. Investigations theorize that the peptide may encourage shifts in metabolic substrate utilization, potentially nudging cells to utilize fatty acid substrates more readily under specific conditions . Such shifts allow scientists to observe how changes in fuel selection may impact cellular ATP production and mitochondrial adaptability.

• Glucose Homeostasis and Insulin Sensitivity: Early foundational studies demonstrated that fragments containing the 176-191 region could influence blood glucose dynamics and insulin sensitivity in research models . These investigations provide a basis for ongoing research into how isolated peptide domains may modulate glucose metabolism independently of broader somatotropic activity.

🧪 Product Specifications & Technical Data

At Buy Peptides Online USA, we ensure your research is built on a foundation of quality and consistency. This peptide is manufactured to rigorous laboratory standards and verified through advanced analytical methods.

✅ Why Choose Buy Peptides Online USA for Your Research?

Sourcing reliable research compounds is critical for reproducible, high-impact science. Here is why researchers across the USA trust us:

• Verified Purity & Potency: We provide access to Certificates of Analysis (COA) and rely on advanced analytical methods like High Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to confirm the molecular weight and purity (>99%) of every batch . This commitment ensures the integrity of your experimental data.
• Research-Focused Integrity: We strictly adhere to research-use-only (RUO) guidelines. Our product descriptions are factual, focusing on chemical properties and cited research applications, never unverified human-use claims.
• Fast & Discreet USA Shipping: We offer fast, reliable shipping across the United States with discreet packaging to ensure your order arrives safely, professionally, and on time for your critical research timelines. Enjoy free shipping on orders over $300.
• Expert Support & Authenticity Guarantee: Our team provides technical consultation to support your work. We stand behind the authenticity and quality of all our products, offering a product replacement service and clear complaint handling.

📝 Handling, Storage, & Important Safety Information

• Handling & Reconstitution: This product is for laboratory use only by qualified professionals. Use proper aseptic technique. Reconstitute by injecting the diluent (e.g., bacteriostatic water) slowly against the inner wall of the vial to prevent foaming. Swirl gently—do not shake, as this can damage the peptide structure . Note that peptides are typically supplied as trifluoroacetate (TFA) salts from the HPLC purification process, which may contribute to total peptide mass .
• Safety: Always wear appropriate personal protective equipment (PPE), including lab coats, gloves, and safety glasses. Dispose of any sharps and biological waste according to your institutional guidelines.
• Stability Considerations: Lyophilized peptides, while stable at room temperature for short periods (up to 3 months), should be stored desiccated at -20°C or below for optimal long-term stability . Once reconstituted, peptides are significantly less stable and should be refrigerated and used promptly. Avoid repeated freeze-thaw cycles at all costs, as these can lead to peptide degradation and reduced bioactivity .
• Warning: This product is not for human or veterinary use. It is not a drug, food, or cosmetic. Do not ingest or inject.

❓ Frequently Asked Questions (FAQs)

Q: What is the difference between hGH Fragment 176-191 and full-length human growth hormone?

A: Fragment 176-191 is a 16-amino acid peptide derived from the C-terminus of the hGH molecule. Unlike full-length hGH, which interacts with growth hormone receptors and influences IGF-1 levels, glucose metabolism, and systemic growth, Fragment 176-191 is theorized to selectively target metabolic pathways, particularly those involved in lipid mobilization, without significantly impacting IGF-1 or blood glucose in research models . This selectivity makes it a valuable tool for dissecting domain-specific contributions to metabolic regulation .

Q: Is hGH Fragment 176-191 the same as AOD-9604?

A: Yes, AOD-9604 is the research name commonly used for this peptide fragment. It was originally developed by Metabolic Pharmaceuticals in Australia as an "Anti-Obesity Drug" candidate and corresponds to hGH Fragment 176-191 with an added tyrosine at the N-terminus . In research literature, the terms are often used interchangeably to refer to this specific C-terminal fragment of human growth hormone.

Q: What is the significance of the disulfide bridge in the peptide structure?

A: The disulfide bridge between cysteine residues at positions 7 and 14 is critical for maintaining the correct three-dimensional conformation of the peptide . This structural feature is essential for bioactivity, as it stabilizes the peptide in its active configuration. The presence of this bridge is confirmed through mass spectrometry analysis, ensuring the peptide's structural integrity.

Q: How do you verify the purity of hGH Fragment 176-191?

A: We ensure every batch is rigorously analyzed using High Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) . HPLC confirms a purity level of ≥99% , while Mass Spectrometry verifies the precise molecular weight (~1815.09 g/mol) and confirms the presence of the critical disulfide bridge, ensuring the correct peptide structure and identity .

Q: What are the critical storage conditions for this lyophilized peptide?

A: Upon arrival, store the lyophilized powder in a freezer at -20°C (-4°F) or lower. It is crucial to keep it desiccated, protected from light, and to avoid repeated freeze-thaw cycles, as these can lead to peptide degradation and reduced bioactivity . Once reconstituted, store at 2-8°C and use promptly.

Q: Is hGH Fragment 176-191 prohibited in sports research?

A: Yes, researchers should be aware that growth hormone fragments and secretagogues are subject to regulation. The World Anti-Doping Agency (WADA) prohibits the use of peptide hormones, releasing factors, and secretagogues. Fragment 176-191 falls within these prohibited categories and is intended for legitimate scientific research only .

Q: What solvent should I use for reconstitution?

A: For optimal solubility and stability in a laboratory setting, sterile bacteriostatic water is commonly used. Sterile water for injection can also be used, but the solution should be used immediately to avoid microbial growth. The TFA salt form of the peptide generally enhances its solubility in aqueous solutions .

Ready to Advance Your Research? 🚀

Equip your laboratory with a trusted research tool. Order high-purity hGH Fragment 176-191 Peptide today from Buy Peptides Online USA. Benefit from our fast USA shipping, secure payments (including crypto), and the confidence that comes from rigorously tested research compounds. For any questions about this product or your order, our support team is here to provide technical consultation.