Hexarelin Peptide

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Unlocking Dual-Receptor Pathways: An Introduction to Hexarelin Peptide 🔬

For researchers focused on the complexities of the neuroendocrine and cardiovascular systems, Hexarelin stands as a uniquely potent and stable research tool. This synthetic hexapeptide, belonging to the family of growth hormone-releasing peptides (GHRPs), is a powerful, full agonist at the growth hormone secretagogue receptor (GHS-R1a) , also known as the ghrelin receptor .

What distinguishes Hexarelin from other GHRPs, such as GHRP-6, is its enhanced resistance to enzymatic degradation, owing to its modification with a methyl group on the tryptophan residue (D-2-methyl-Trp) . This structural feature contributes to its robust and sustained activity in research models. Furthermore, Hexarelin has garnered significant attention for its ability to bind to a second, distinct receptor—CD36—a scavenger receptor expressed on cardiomyocytes and macrophages, opening unique avenues for cardiovascular research beyond the classic GH axis .

What is Hexarelin Peptide?
Hexarelin is a synthetic peptide analogue of met-enkephalin, designed not for opioid activity but for potent GH-releasing properties. Its full sequence is His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH₂ . It functions by binding to and activating the GHS-R1a in the pituitary and hypothalamus, stimulating the pulsatile release of growth hormone. However, the peripheral distribution of its receptors, particularly CD36 in the heart and blood vessels, suggests it has direct, GH-independent actions that are a major focus of current research .

🔬 Primary Research Focuses and Applications

The Hexarelin Peptide is utilized in scientific research to investigate a broad spectrum of physiological and pharmacological questions:

• Cardiovascular Protection & Ischemia-Reperfusion Injury: A leading area of Hexarelin research involves its cardioprotective properties. Studies suggest it can protect cardiomyocytes from ischemia/reperfusion (I/R) injury. This effect is partly mediated through the IL-1 signaling pathway and the activation of the PI3K/Akt survival pathway, primarily via its interaction with the CD36 receptor in the heart, independent of GH release .
• Metabolic Regulation & Diabetes Research: Hexarelin has been shown to regulate peroxisome proliferator-activated receptor gamma (PPAR-γ) in macrophages and adipocytes, a key regulator of adipogenesis, lipid metabolism, and insulin sensitization. This makes it a valuable tool for studying metabolic disorders, including diabetes and diabetic cardiomyopathy .
• Comparative GHS-R1a Pharmacology: Due to its enhanced stability and potency, Hexarelin is often used in comparative studies with other GHSs like GHRP-6 and ghrelin to map receptor-ligand binding affinities, downstream signaling cascades, and patterns of GH pulse amplification .
• Bone Metabolism and Cellular Proliferation: As a potent GH secretagogue, Hexarelin is also relevant for research into the GH-IGF-1 axis and its influence on osteoblast proliferation and differentiation, contributing to studies on bone mineral density and growth .

🧪 Product Specifications & Technical Data

At Buy Peptides Online USA, we ensure your research is built on a foundation of quality and consistency. This peptide is manufactured to rigorous laboratory standards.

✅ Why Choose Buy Peptides Online USA for Your Research?

Sourcing reliable research compounds is critical for reproducible, high-impact science. Here is why researchers across the USA trust us:

• Verified Purity & Potency: We provide access to Certificates of Analysis (COA) and rely on advanced analytical methods like Reverse-Phase High Performance Liquid Chromatography (RP-HPLC) and Mass Spectrometry (MS) to confirm the molecular weight and purity (>99%) of every batch . This commitment ensures the integrity of your experimental data.
• Research-Focused Integrity: We strictly adhere to research-use-only (RUO) guidelines. Our product descriptions are factual, focusing on chemical properties and cited research applications, never unverified human-use claims.
• Fast & Discreet USA Shipping: We offer fast, reliable shipping across the United States with discreet packaging to ensure your order arrives safely, professionally, and on time for your critical research timelines. Enjoy free shipping on orders over $300.
• Expert Support & Authenticity Guarantee: Our team provides technical consultation to support your work. We stand behind the authenticity and quality of all our products, offering a product replacement service and clear complaint handling.

📝 Handling, Storage, & Important Safety Information

• Handling & Reconstitution: This product is for laboratory use only by qualified professionals. Use proper aseptic technique. Reconstitute by injecting the diluent (e.g., bacteriostatic water) slowly against the inner wall of the vial to prevent foaming. Swirl gently—do not shake, as this can damage the peptide structure.
• Stability Considerations: Hexarelin is stable, but to maintain its integrity, it is critical to store the lyophilized powder desiccated, protected from light, and to avoid repeated freeze-thaw cycles, as these can lead to degradation and reduced bioactivity .
• Safety: Always wear appropriate personal protective equipment (PPE), including lab coats, gloves, and safety glasses. Dispose of any sharps and biological waste according to your institutional guidelines.
• Warning: This product is not for human or veterinary use. It is not a drug, food, or cosmetic. Do not ingest or inject.

❓ Frequently Asked Questions (FAQs)

Q: What makes Hexarelin different from other GHRPs like GHRP-2 or GHRP-6?

A: Hexarelin is structurally similar to GHRP-6 but contains a methyl group on the D-tryptophan residue (D-2-methyl-Trp). This modification makes Hexarelin significantly more resistant to enzymatic breakdown, resulting in enhanced stability and a longer duration of action in research models compared to GHRP-6 . Furthermore, its well-documented ability to bind to the CD36 receptor gives it a unique profile in cardiovascular research .

Q: What is the significance of the CD36 receptor in Hexarelin research?

A: CD36 is a scavenger receptor found on various cells, including cardiomyocytes (heart muscle cells) and macrophages. Research indicates that Hexarelin's cardioprotective effects, particularly against ischemia-reperfusion injury, are mediated through its binding to CD36 and the subsequent activation of protective signaling pathways like PI3K/Akt, independently of GH release . This makes Hexarelin a unique tool for studying GH-independent cardioprotection.

Q: How do you verify the purity of Hexarelin?

A: We ensure every batch is rigorously analyzed using Reverse-Phase High Performance Liquid Chromatography (RP-HPLC) and Mass Spectrometry (MS) . HPLC confirms a purity level of ≥99% , while Mass Spectrometry verifies the precise molecular weight (~887.04 g/mol), ensuring the correct peptide structure and identity .

Q: What are the critical storage conditions for this lyophilized peptide?

A: Upon arrival, store the lyophilized powder in a freezer at -20°C (-4°F) or lower. It is crucial to keep it desiccated, protected from light, and to avoid repeated freeze-thaw cycles, as these can lead to peptide degradation .

Q: Is Hexarelin prohibited in sports research?

A: Yes, researchers should be aware that Hexarelin is classified as a growth hormone secretagogue and is included on the World Anti-Doping Agency (WADA) Prohibited List. It is subject to detection in doping control analyses and is intended for legitimate scientific research only.

Ready to Advance Your Research? 🚀

Equip your laboratory with a trusted research tool. Order high-purity Hexarelin Peptide today from Buy Peptides Online USA. Benefit from our fast USA shipping, secure payments (including crypto), and the confidence that comes from rigorously tested research compounds. For any questions about this product or your order, our support team is here to provide technical consultation.