Hexarelin, CJC-1295 no DAC (Mod GRF 1-29) Blend

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Unlocking Synergistic Potential: The Hexarelin and CJC-1295 no DAC Peptide Blend 🔬

For researchers focused on the complex architecture of the Growth Hormone (GH) axis and its intersection with cardiovascular signaling, the Hexarelin, CJC-1295 no DAC (Mod GRF 1-29) Blend offers a sophisticated and powerful tool. This pre-formulated combination unites a uniquely stable and pluripotent growth hormone secretagogue (GHS) with a physiologically relevant growth hormone-releasing hormone (GHRH) analog to explore their theorized synergistic effects on somatotropic and cardiometabolic pathways .

Instead of sourcing and dosing these peptides separately, this blend provides a consistent ratio, reducing variables in your experimental protocols. This dual-action approach allows for a nuanced examination of how GHS-R1a activation (via Hexarelin) and GHRH receptor stimulation (via CJC-1295 no DAC) integrate to influence GH pulsatility, downstream effector molecules like IGF-1, and direct, GH-independent pathways mediated by Hexarelin's interaction with the CD36 receptor .

What is Hexarelin and CJC-1295 no DAC?

• Hexarelin: A synthetic hexapeptide and exceptionally stable, potent, full agonist of the growth hormone secretagogue receptor (GHS-R1a) . Its enhanced resistance to enzymatic degradation, owing to a methyl group on the tryptophan residue, results in robust and sustained activity in research models. Crucially, Hexarelin is distinguished by its ability to bind to CD36, a scavenger receptor expressed on cardiomyocytes, opening unique avenues for cardiovascular research beyond the classic GH axis .
• CJC-1295 without DAC (Drug Affinity Complex): Often referred to as Modified GRF (1-29) , this peptide is a synthetic analog of endogenous GHRH . The "no DAC" version has a shorter half-life (approximately 30 minutes to an hour) compared to its DAC-bound counterpart . This shorter activity window is theorized to stimulate GH release in a more physiological, pulsatile pattern, which is crucial for studying natural GH pulse dynamics and avoiding potential receptor desensitization associated with continuous stimulation. Its molecular formula is C₁₅₂H₂₅₂N₄₄O₄₂ with a molecular weight of approximately 3367.9 g/mol .

🔬 Primary Research Focuses and Applications

The Hexarelin & CJC-1295 no DAC Blend is primarily utilized in scientific research to investigate:

• Synergistic GH Pulse Amplification: Studying how a uniquely stable GHS-R1a agonist (Hexarelin) and a GHRH analog (CJC-1295 no DAC) work together to potentially amplify GH pulses, offering a model for understanding the body's natural GH regulation and the integration of dual-receptor signaling .
• Cardiovascular Protection & Ischemia-Reperfusion Injury: A leading area of Hexarelin research involves its cardioprotective properties, mediated through binding to the CD36 receptor on cardiomyocytes. This blend allows researchers to study these direct cardiac pathways in conjunction with systemic GH/IGF-1 signaling .
• Metabolic Regulation & Receptor-Level Interactions: Exploring the role of enhanced GH-IGF-1 signaling in lipid metabolism (lipolysis) and energy homeostasis, while also examining the distinct signaling cascades triggered by GHS-R1a activation (via Hexarelin) versus GHRH-R activation (via CJC-1295) .
• Dual-Pathway GPCR Signaling: Utilizing the blend to map the integration of signals from two different G-protein-coupled receptors (GPCRs)—GHS-R1a and GHRH-R—providing insights into how cells integrate multiple hormonal inputs to produce a coordinated response .
• Pulsatile vs. Sustained Activation Paradigms: Comparing the effects of the pulsatile GH release stimulated by CJC-1295 no DAC with the more sustained activity of Hexarelin to understand the importance of GH pulse patterns on target tissues .

🧪 Product Specifications & Technical Data

At Buy Peptides Online USA, we ensure your research is built on a foundation of quality and consistency. This blend is manufactured to rigorous laboratory standards.

✅ Why Choose Buy Peptides Online USA for Your Research?

Sourcing reliable research compounds is critical for reproducible, high-impact science. Here is why researchers across the USA trust us:

• Verified Purity & Potency: We provide access to Certificates of Analysis (COA) and rely on advanced analytical methods like High Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to confirm the molecular weight and purity (>99%) of every batch . This commitment ensures the integrity of your experimental data.
• Research-Focused Integrity: We strictly adhere to research-use-only (RUO) guidelines. Our product descriptions are factual, focusing on chemical properties and cited research applications, never unverified human-use claims .
• Fast & Discreet USA Shipping: We offer fast, reliable shipping across the United States with discreet packaging to ensure your order arrives safely, professionally, and on time for your critical research timelines. Enjoy free shipping on orders over $300.
• Expert Support & Authenticity Guarantee: Our team provides technical consultation to support your work. We stand behind the authenticity and quality of all our products, offering a product replacement service and clear complaint handling.

📝 Handling, Storage, & Important Safety Information

• Handling & Reconstitution: This product is for laboratory use only by qualified professionals. Use proper aseptic technique. Reconstitute by injecting the diluent (e.g., bacteriostatic water) slowly against the inner wall of the vial to prevent foaming. Swirl gently—do not shake, as this can damage the peptide structure .
• Safety: Always wear appropriate personal protective equipment (PPE), including lab coats, gloves, and safety glasses. Dispose of any sharps and biological waste according to your institutional guidelines .
• Stability Considerations: The lyophilized powder is stable for over two years when stored at -20°C . However, once reconstituted, peptides are significantly less stable. Store in a refrigerator and use promptly. Avoid repeated freeze-thaw cycles at all costs, as these can lead to peptide degradation and reduced bioactivity .
• Warning: This product is not for human or veterinary use. It is not a drug, food, or cosmetic. Do not ingest or inject .

❓ Frequently Asked Questions (FAQs)

Q: What is the primary research advantage of blending Hexarelin with CJC-1295 no DAC?

A: The blend combines the uniquely stable, GHS-R1a-mediated GH release and CD36-mediated cardioprotective signaling of Hexarelin with the physiological, pulsatile GHRH stimulation of CJC-1295 no DAC . This dual-pathway activation allows researchers to study a more complete model of GH axis regulation alongside direct cardiac pathways.

Q: What is the difference between CJC-1295 with DAC and without DAC?

A: The presence of DAC (Drug Affinity Complex) significantly extends the peptide's half-life in a research model (to about 8 days) . CJC-1295 no DAC has a much shorter half-life (around 30 minutes to an hour) and is theorized to stimulate GH release in a more natural, pulsatile fashion, which is often preferred for studies aiming to mimic endogenous secretion patterns . This blend uses the no DAC version specifically for this reason.

Q: What is the significance of the CD36 receptor in Hexarelin research?

A: CD36 is a scavenger receptor found on various cells, including cardiomyocytes (heart muscle cells) and macrophages. Research indicates that Hexarelin's cardioprotective effects, particularly against ischemia-reperfusion injury, are mediated through its binding to CD36 and the subsequent activation of protective signaling pathways like PI3K/Akt, independently of GH release . This makes Hexarelin a unique tool for studying GH-independent cardioprotection.

Q: How do you verify the purity of the blend?

A: We ensure every batch is rigorously analyzed using High Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) . HPLC confirms a purity level of ≥99% , while Mass Spectrometry verifies the precise molecular weight of both components, ensuring the correct peptide structure and identity .

Q: What are the critical storage conditions for this lyophilized peptide?

A: Upon arrival, store the lyophilized powder in a freezer at -20°C (-4°F) or lower. It is crucial to keep it desiccated, protected from light, and to avoid repeated freeze-thaw cycles, as these can lead to peptide degradation and reduced bioactivity .

Q: Is Hexarelin prohibited in sports research?

A: Yes, researchers should be aware that Hexarelin is classified as a growth hormone secretagogue and is included on the World Anti-Doping Agency (WADA) Prohibited List. It is subject to detection in doping control analyses and is intended for legitimate scientific research only.

Ready to Advance Your Research? 🚀

Equip your laboratory with a trusted research tool. Order the high-purity Hexarelin, CJC-1295 no DAC (Mod GRF 1-29) Blend today from Buy Peptides Online USA. Benefit from our fast USA shipping, secure payments (including crypto), and the confidence that comes from rigorously tested research compounds. For any questions about this product or your order, our support team is here to provide technical consultation.