Premium 5-Amino-1MQ Capsules: High-Purity NNMT Inhibitor for Metabolic Research

5-Amino-1MQ Capsules offer a highly stable and convenient oral formulation for advanced metabolic and aging research. 🧬 This potent small-molecule inhibitor targets nicotinamide N-methyltransferase (NNMT), a key enzyme in cellular energy regulation. Our capsules contain meticulously measured, high-purity 5-Amino-1MQ powder in a vegan cellulose shell, providing precise dosing and enhanced stability for studies on mitochondrial function, NAD+ metabolism, adipose tissue biology, and metabolic health.

🔬 What Is 5-Amino-1MQ? A Pioneering Small Molecule for Metabolic Research

5-Amino-1MQ (also known chemically as 5-Amino-1-methylquinolinium) is a potent and selective small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). Unlike peptides, which are chains of amino acids, 5-Amino-1MQ belongs to the quinolinium class of compounds and represents a significant tool in the field of metabolic epigenetics and aging biology.

NNMT plays a crucial regulatory role in cellular metabolism by methylating nicotinamide (a form of vitamin B3), effectively sequestering it and altering the availability of substrates for the NAD+ salvage pathway. NAD+ (nicotinamide adenine dinucleotide) is a fundamental coenzyme critical for mitochondrial energy production, DNA repair, and cellular signaling. Elevated NNMT activity, observed in aged tissues and metabolic disorders, is associated with decreased NAD+ levels and disrupted metabolic homeostasis.

Therefore, 5-Amino-1MQ serves as a precise pharmacological probe in research. By inhibiting NNMT, it allows scientists to investigate the downstream effects on NAD+ metabolism, mitochondrial function, insulin sensitivity, and adipose tissue remodeling. Its primary research purpose is to explore the mechanistic links between epigenetic regulation of metabolism, aging, and age-related metabolic decline in preclinical models.

⚗️ Chemical Structure and Specifications

Understanding the chemical identity of 5-Amino-1MQ is fundamental for proper research application and documentation.

• Systematic Name: 5-Amino-1-methylquinolinium
• Molecular Formula: C₁₀H₁₃N₂⁺
• Molecular Weight: 161.22 g/mol (for the cation)
• CAS Number: 1190-68-1
• PubChem CID: 155279
• Chemical Structure: It consists of a quinolinium core—a bicyclic structure resembling a benzene ring fused to a pyridine ring—with an amino (-NH₂) group at the 5-position and a methyl group on the nitrogen atom at the 1-position, giving it a positive charge.

5-Amino-1MQ Capsules Specifications Table

For accurate research planning and material accountability, please refer to the following product specifications.

🧪 Primary Research Applications and Scientific Focus

5-Amino-1MQ is a powerful investigative tool in several cutting-edge areas of biomedical research due to its specific mechanism of action.

• Metabolic Disease & Obesity Research: 🏃‍♂️ A major research focus is on metabolic syndrome and adipose tissue biology. Studies investigate how NNMT inhibition affects white adipose tissue (WAT) remodeling, energy expenditure, and glucose homeostasis in models of diet-induced obesity. Research aims to understand its potential role in modulating insulin sensitivity and lipid metabolism.
• NAD+ Biology and Aging (Geroscience): ⌛ By inhibiting NNMT, 5-Amino-1MQ research explores its impact on boosting cellular NAD+ levels. This connects directly to sirtuin activity (NAD+-dependent deacetylases), which regulates mitochondrial biogenesis, stress resistance, and genomic stability. This makes it a key compound for studying interventions in age-related metabolic decline and promoting healthy aging.
• Mitochondrial Function and Bioenergetics: 🔋 Researchers use 5-Amino-1MQ to probe the relationship between NNMT activity and mitochondrial efficiency. Studies measure outcomes like oxygen consumption rate (OCR), ATP production, and reactive oxygen species (ROS) management in various tissues.
• Cognitive Function and Neurodegeneration: 🧠 Emerging research investigates NNMT’s role in the brain. Studies using 5-Amino-1MQ examine its effects on neuronal metabolism, neuroinflammation, and cognitive performance in models relevant to age-related cognitive decline and neurodegenerative diseases.
• Cancer Metabolism: Some research explores the role of NNMT in tumor metabolism, as cancer cells often exhibit altered methyltransferase activity and NAD+ dependency.

📊 Certificate of Analysis (COA) and Quality Assurance

While capsules are a formulated product, our commitment to quality begins with the raw material. We provide transparency through documentation of the active ingredient.

Our Quality Verification for the Active Compound Includes:

1. High-Performance Liquid Chromatography (HPLC): The primary method for verifying purity. The COA for the batch of 5-Amino-1MQ powder used in encapsulation shows a chromatographic purity of ≥98%, confirming a high concentration of the active molecule and minimal synthesis impurities.
2. Mass Spectrometry (MS): Mass spectrometry analysis is used to definitively confirm the identity of the compound. It verifies the molecular weight and fragmentation pattern match the expected profile for 5-Amino-1-methylquinolinium (C₁₀H₁₃N₂⁺).

The batch-specific Certificate of Analysis (COA) is available upon request and provides data from these analytical tests performed on the bulk raw material prior to encapsulation. This ensures researchers that the active ingredient within the capsule meets high standards of chemical identity and purity.

📦 Handling, Storage, and Research Use Guidelines

Optimal Storage Conditions

• Capsules: Store in the original, tightly sealed container in a cool, dry place at room temperature (15-25°C / 59-77°F).
• Protect from: Light, moisture, and excessive heat. Do not refrigerate or freeze, as condensation can damage the capsules.
• Keep Out of Reach: Ensure secure storage away from unauthorized access, in accordance with laboratory safety protocols.

Instructions for Research Use

⚠️ Critical Note: The following describes a general research approach. All in vivo work must be conducted under an approved Institutional Animal Care and Use Committee (IACUC) protocol.

1. Dosage Considerations: 🧫
   • There is no universal “standard” dose. Published preclinical studies in rodents typically use doses ranging from 1 to 10 mg per kilogram of body weight per day, administered orally.
   • The specific dosage and frequency (e.g., once daily) must be carefully determined by the researcher based on their model, research objectives, and a review of relevant scientific literature. Starting with a lower dose for a pilot study is always prudent.
2. Administration in Preclinical Models:
   • For rodents (mice/rats), the capsule can be opened, and the pre-measured powder can be mixed into a small amount of vehicle (e.g., a gelling agent like 0.5% methylcellulose) for oral gavage.
   • Alternatively, for voluntary consumption studies, the powder can be carefully mixed into a small, palatable food treat or a defined amount of liquid diet, ensuring complete consumption.
   • Accurate record-keeping of the exact dose administered per subject is essential.

⚠️ Critical Research and Safety Notice: 5-Amino-1MQ Capsules are provided as a research chemical in a convenient oral form. They are NOT for human consumption, not a dietary supplement, and not intended for diagnostic or therapeutic use. This product is for use in controlled laboratory experiments only. Researchers assume full responsibility for:

• Designing and conducting ethically approved animal studies.
• Proper personal protective equipment (PPE) when handling opened capsules or powder.
• Compliance with all institutional, local, and federal regulations regarding chemical use and disposal.

❓ Frequently Asked Questions (FAQs)

Q: Is 5-Amino-1MQ a peptide?

A: No, it is not a peptide. 5-Amino-1MQ is a small synthetic molecule belonging to the quinolinium class. It has a low molecular weight (161 g/mol) and a completely different chemical structure and synthesis pathway compared to peptides, which are chains of amino acids. Its research applications in metabolism are distinct from most peptide pathways.

Q: What are the main benefits of the capsule form over raw powder?

A: Capsules offer several advantages for research:

*   **Pre-Measured Dosing:** Each capsule contains a precise, pre-weighed amount, eliminating weighing errors and saving time.
*   **Enhanced Stability:** Protects the hygroscopic (moisture-absorbing) powder from degradation due to humidity and light.
*   **Handling Safety:** Reduces researcher exposure to fine powder during dose preparation.
*   **Convenience:** Simplifies the logistics of dosing in animal studies.

Q: Can I get the Certificate of Analysis for the capsules?

A: Yes. We provide a batch-specific COA that details the analytical testing (HPLC, MS) performed on the batch of 5-Amino-1MQ raw material used to produce these capsules. This confirms the identity and purity of the active compound you are administering.

Q: What is a typical research dosage in mouse studies?

A: Dosage is study-dependent. In published literature investigating metabolic effects in mice, common oral doses range from 2.5 mg/kg to 10 mg/kg administered daily. The optimal dosage and administration schedule must be determined by the researcher through pilot studies and a thorough review of current scientific publications relevant to their specific research question.

Q: How are the capsules shipped?

A: Capsules are shipped in secure, discreet packaging:

*   **Domestic USA:** Standard shipping, typically 3-7 business days.
*   **International:** Available to most countries for the research community; customers are responsible for verifying local import regulations.
*   Capsules are sealed in a plastic bottle within an outer box.

Q: What support services do you offer?
A: Our commitment to the research community includes:

*   **Product Support:** Access to batch COAs and basic product information.
*   **Order Support:** Assistance with tracking and logistics.
*   **Replacement Policy:** For products verified as damaged during shipping.

🔬 Explore the frontier of metabolic regulation. 5-Amino-1MQ Capsules provide a reliable, convenient tool to investigate critical pathways in aging, obesity, and cellular energy. Order your supply today to advance your research into NAD+ biology, mitochondrial health, and metabolic epigenetics with a high-quality, precisely formulated compound.